Common genetic mechanisms implicated in Antibiotic Resistance
Antibiotic resistance is conferred through a large pool of genes, which is now referred to as the resistome. The appearance of the ever-changing structure of a cistron in the macromolecule together with the key factors of primary mutations, and evolution that translates the ability to grow in the p...
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| Format: | Article |
| Language: | English |
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University of Sarajevo, Institute for Genetic Engineering and Biotechnology
2022-06-01
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| Series: | Genetics & Applications |
| Subjects: | |
| Online Access: | https://genapp.ba/editions/index.php/journal/article/view/68 |
| _version_ | 1811185777340579840 |
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| author | Ridwan Olamilekan Adesola Ogundepo Oluwatobi Moses |
| author_facet | Ridwan Olamilekan Adesola Ogundepo Oluwatobi Moses |
| author_sort | Ridwan Olamilekan Adesola |
| collection | DOAJ |
| description |
Antibiotic resistance is conferred through a large pool of genes, which is now referred to as the resistome. The appearance of the ever-changing structure of a cistron in the macromolecule together with the key factors of primary mutations, and evolution that translates the ability to grow in the presence of antibiotics to microorganism is creating a natural selection, causing those who are vulnerable to scale back in population whereas those who have the flexibility to grow in the presence of antibiotics to flourish. In addition, mechanisms of horizontal gene switch transfer among bacteria of the same species and interspecies have been involved in the distribution of antibiotic resistant genes amenable for unique mechanisms which allow them to overwhelm antibiotics found in their on-the-spot surroundings among other organisms. The most horrifying aspect of these resistance genes is that their components are frequently deployed into the microbic community, which affects humans, thanks to the involvement of genetic level which expeditiously assist the mobilization and maintenance of those resistant genes. These genes include those that impact linezolid methyltransferases (cfr), aminoglycoside ribosomal methylases (armA, rtmB), efflux pumps giving fluoroquinolone resistance (qepA), and biofilm resistance all of which are related to antimicrobial-producing bacteria. This work aims to reveal and discuss the various identified genetic mechanisms used by antibiotic-resistant bacteria.
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| first_indexed | 2024-04-11T13:36:05Z |
| format | Article |
| id | doaj.art-05901330514a4dbc98dc933ea05744c4 |
| institution | Directory Open Access Journal |
| issn | 2566-2937 2566-431X |
| language | English |
| last_indexed | 2024-04-11T13:36:05Z |
| publishDate | 2022-06-01 |
| publisher | University of Sarajevo, Institute for Genetic Engineering and Biotechnology |
| record_format | Article |
| series | Genetics & Applications |
| spelling | doaj.art-05901330514a4dbc98dc933ea05744c42022-12-22T04:21:29ZengUniversity of Sarajevo, Institute for Genetic Engineering and BiotechnologyGenetics & Applications2566-29372566-431X2022-06-016110.31383/ga.vol6iss1pp1-10Common genetic mechanisms implicated in Antibiotic ResistanceRidwan Olamilekan Adesola0Ogundepo Oluwatobi Moses11Department of Veterinary medicine, Faculty of Veterinary Medicine, University of Ibadan, Ibadan, Oyo State, NigeriaDepartment of Microbiology, University of Lagos, Akoka, Lagos State, Nigeria Antibiotic resistance is conferred through a large pool of genes, which is now referred to as the resistome. The appearance of the ever-changing structure of a cistron in the macromolecule together with the key factors of primary mutations, and evolution that translates the ability to grow in the presence of antibiotics to microorganism is creating a natural selection, causing those who are vulnerable to scale back in population whereas those who have the flexibility to grow in the presence of antibiotics to flourish. In addition, mechanisms of horizontal gene switch transfer among bacteria of the same species and interspecies have been involved in the distribution of antibiotic resistant genes amenable for unique mechanisms which allow them to overwhelm antibiotics found in their on-the-spot surroundings among other organisms. The most horrifying aspect of these resistance genes is that their components are frequently deployed into the microbic community, which affects humans, thanks to the involvement of genetic level which expeditiously assist the mobilization and maintenance of those resistant genes. These genes include those that impact linezolid methyltransferases (cfr), aminoglycoside ribosomal methylases (armA, rtmB), efflux pumps giving fluoroquinolone resistance (qepA), and biofilm resistance all of which are related to antimicrobial-producing bacteria. This work aims to reveal and discuss the various identified genetic mechanisms used by antibiotic-resistant bacteria. https://genapp.ba/editions/index.php/journal/article/view/68ResistomeAntibiotics resistancehorizontal gene transferResistance gene |
| spellingShingle | Ridwan Olamilekan Adesola Ogundepo Oluwatobi Moses Common genetic mechanisms implicated in Antibiotic Resistance Genetics & Applications Resistome Antibiotics resistance horizontal gene transfer Resistance gene |
| title | Common genetic mechanisms implicated in Antibiotic Resistance |
| title_full | Common genetic mechanisms implicated in Antibiotic Resistance |
| title_fullStr | Common genetic mechanisms implicated in Antibiotic Resistance |
| title_full_unstemmed | Common genetic mechanisms implicated in Antibiotic Resistance |
| title_short | Common genetic mechanisms implicated in Antibiotic Resistance |
| title_sort | common genetic mechanisms implicated in antibiotic resistance |
| topic | Resistome Antibiotics resistance horizontal gene transfer Resistance gene |
| url | https://genapp.ba/editions/index.php/journal/article/view/68 |
| work_keys_str_mv | AT ridwanolamilekanadesola commongeneticmechanismsimplicatedinantibioticresistance AT ogundepooluwatobimoses commongeneticmechanismsimplicatedinantibioticresistance |