Variable radiographic and histologic presentations of amiodarone‐related interstitial lung disease and the importance of avoiding re‐exposure
Abstract Amiodarone is a commonly used antiarrhythmic agent but exhibits potential pulmonary toxicity. In this case series, we describe the clinical, radiographic, and histologic manifestations of three patients who developed interstitial lung disease (ILD) following amiodarone treatment for variabl...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-06-01
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| Series: | Respirology Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rcr2.1165 |
| _version_ | 1797819927883677696 |
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| author | I‐Lin Tsai Li‐Ting Huang Yu‐Ting Yu Chung‐Ta Lee Tang‐Hsiu Huang |
| author_facet | I‐Lin Tsai Li‐Ting Huang Yu‐Ting Yu Chung‐Ta Lee Tang‐Hsiu Huang |
| author_sort | I‐Lin Tsai |
| collection | DOAJ |
| description | Abstract Amiodarone is a commonly used antiarrhythmic agent but exhibits potential pulmonary toxicity. In this case series, we describe the clinical, radiographic, and histologic manifestations of three patients who developed interstitial lung disease (ILD) following amiodarone treatment for variable lengths of time with different dosages. The presentations on computed tomographic images and in pulmonary pathology differed among the three patients. All three had immediate discontinuation of amiodarone and received treatment with systemic corticosteroids. One patient eventually died from ventilator‐associated pneumonia after an initial improvement. The other two patients recovered well but later experienced ILD recurrence following brief re‐exposure to amiodarone. Through this case series, we aim to demonstrate the variable features of amiodarone‐related ILD, and highlight the importance of timely amiodarone cessation and avoiding re‐exposure to prevent the progression and recurrence of ILD. |
| first_indexed | 2024-03-13T09:29:49Z |
| format | Article |
| id | doaj.art-059158f2cd344efca7674168af592e3f |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-03-13T09:29:49Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-059158f2cd344efca7674168af592e3f2023-05-26T03:14:31ZengWileyRespirology Case Reports2051-33802023-06-01116n/an/a10.1002/rcr2.1165Variable radiographic and histologic presentations of amiodarone‐related interstitial lung disease and the importance of avoiding re‐exposureI‐Lin Tsai0Li‐Ting Huang1Yu‐Ting Yu2Chung‐Ta Lee3Tang‐Hsiu Huang4Division of Chest Medicine, Department of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanDepartment of Diagnostic Radiology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanDepartment of Pathology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanDepartment of Pathology National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanDivision of Chest Medicine, Department of Internal Medicine National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University Tainan TaiwanAbstract Amiodarone is a commonly used antiarrhythmic agent but exhibits potential pulmonary toxicity. In this case series, we describe the clinical, radiographic, and histologic manifestations of three patients who developed interstitial lung disease (ILD) following amiodarone treatment for variable lengths of time with different dosages. The presentations on computed tomographic images and in pulmonary pathology differed among the three patients. All three had immediate discontinuation of amiodarone and received treatment with systemic corticosteroids. One patient eventually died from ventilator‐associated pneumonia after an initial improvement. The other two patients recovered well but later experienced ILD recurrence following brief re‐exposure to amiodarone. Through this case series, we aim to demonstrate the variable features of amiodarone‐related ILD, and highlight the importance of timely amiodarone cessation and avoiding re‐exposure to prevent the progression and recurrence of ILD.https://doi.org/10.1002/rcr2.1165amiodaroneinterstitial lung diseasespneumonia |
| spellingShingle | I‐Lin Tsai Li‐Ting Huang Yu‐Ting Yu Chung‐Ta Lee Tang‐Hsiu Huang Variable radiographic and histologic presentations of amiodarone‐related interstitial lung disease and the importance of avoiding re‐exposure Respirology Case Reports amiodarone interstitial lung diseases pneumonia |
| title | Variable radiographic and histologic presentations of amiodarone‐related interstitial lung disease and the importance of avoiding re‐exposure |
| title_full | Variable radiographic and histologic presentations of amiodarone‐related interstitial lung disease and the importance of avoiding re‐exposure |
| title_fullStr | Variable radiographic and histologic presentations of amiodarone‐related interstitial lung disease and the importance of avoiding re‐exposure |
| title_full_unstemmed | Variable radiographic and histologic presentations of amiodarone‐related interstitial lung disease and the importance of avoiding re‐exposure |
| title_short | Variable radiographic and histologic presentations of amiodarone‐related interstitial lung disease and the importance of avoiding re‐exposure |
| title_sort | variable radiographic and histologic presentations of amiodarone related interstitial lung disease and the importance of avoiding re exposure |
| topic | amiodarone interstitial lung diseases pneumonia |
| url | https://doi.org/10.1002/rcr2.1165 |
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