Bone marrow contribution to eosinophilic inflammation
Allergen-induced bone marrow responses are observable in human allergic asthmatics, involving specific increases in eosinophil-basophil progenitors (Eo/B-CFU), measured either by hemopoietic assays or by flow cytometric analyses of CD34-positive, IL-3Ralpha-positive, and/or IL-5-responsive cell popu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Fundação Oswaldo Cruz (FIOCRUZ)
1997-01-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800006 |
| _version_ | 1797721324088459264 |
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| author | Denburg Judah A Wood Lorna Gauvreau Gail Sehmi Roma Inman Mark D O'Byrne Paul M |
| author_facet | Denburg Judah A Wood Lorna Gauvreau Gail Sehmi Roma Inman Mark D O'Byrne Paul M |
| author_sort | Denburg Judah A |
| collection | DOAJ |
| description | Allergen-induced bone marrow responses are observable in human allergic asthmatics, involving specific increases in eosinophil-basophil progenitors (Eo/B-CFU), measured either by hemopoietic assays or by flow cytometric analyses of CD34-positive, IL-3Ralpha-positive, and/or IL-5-responsive cell populations. The results are consistent with the upregulation of an IL-5-sensitive population of progenitors in allergen-induced late phase asthmatic responses. Studies in vitro on the phenotype of developing eosinophils and basophils suggest that the early acquisition of IL-5Ralpha, as well as the capacity to produce cytokines such as GM-CSF and IL-5, are features of the differentiation process. These observations are consistent with findings in animal models, indicating that allergen-induced increases in bone marrow progenitor formation depend on hemopoietic factor(s) released post-allergen. The possibility that there is constitutive marrow upregulation of eosinophilopoiesis in allergic airways disease is also an area for future investigation. |
| first_indexed | 2024-03-12T09:31:48Z |
| format | Article |
| id | doaj.art-0591ab54359c4d07b686268214e2af88 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T09:31:48Z |
| publishDate | 1997-01-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-0591ab54359c4d07b686268214e2af882023-09-02T13:54:01ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601997-01-0192suppl.23335Bone marrow contribution to eosinophilic inflammationDenburg Judah AWood LornaGauvreau GailSehmi RomaInman Mark DO'Byrne Paul MAllergen-induced bone marrow responses are observable in human allergic asthmatics, involving specific increases in eosinophil-basophil progenitors (Eo/B-CFU), measured either by hemopoietic assays or by flow cytometric analyses of CD34-positive, IL-3Ralpha-positive, and/or IL-5-responsive cell populations. The results are consistent with the upregulation of an IL-5-sensitive population of progenitors in allergen-induced late phase asthmatic responses. Studies in vitro on the phenotype of developing eosinophils and basophils suggest that the early acquisition of IL-5Ralpha, as well as the capacity to produce cytokines such as GM-CSF and IL-5, are features of the differentiation process. These observations are consistent with findings in animal models, indicating that allergen-induced increases in bone marrow progenitor formation depend on hemopoietic factor(s) released post-allergen. The possibility that there is constitutive marrow upregulation of eosinophilopoiesis in allergic airways disease is also an area for future investigation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800006hemopoiesisasthmainflammationIL-5eosinophilsbasophils |
| spellingShingle | Denburg Judah A Wood Lorna Gauvreau Gail Sehmi Roma Inman Mark D O'Byrne Paul M Bone marrow contribution to eosinophilic inflammation Memorias do Instituto Oswaldo Cruz hemopoiesis asthma inflammation IL-5 eosinophils basophils |
| title | Bone marrow contribution to eosinophilic inflammation |
| title_full | Bone marrow contribution to eosinophilic inflammation |
| title_fullStr | Bone marrow contribution to eosinophilic inflammation |
| title_full_unstemmed | Bone marrow contribution to eosinophilic inflammation |
| title_short | Bone marrow contribution to eosinophilic inflammation |
| title_sort | bone marrow contribution to eosinophilic inflammation |
| topic | hemopoiesis asthma inflammation IL-5 eosinophils basophils |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761997000800006 |
| work_keys_str_mv | AT denburgjudaha bonemarrowcontributiontoeosinophilicinflammation AT woodlorna bonemarrowcontributiontoeosinophilicinflammation AT gauvreaugail bonemarrowcontributiontoeosinophilicinflammation AT sehmiroma bonemarrowcontributiontoeosinophilicinflammation AT inmanmarkd bonemarrowcontributiontoeosinophilicinflammation AT obyrnepaulm bonemarrowcontributiontoeosinophilicinflammation |