Serological response to influenza vaccination among children vaccinated for multiple influenza seasons.
<h4>Background</h4>To evaluate if, among children aged 3 to 15 years, influenza vaccination for multiple seasons affects the proportion sero-protected.<h4>Methodology/principal findings</h4>Participants were 131 healthy children aged 3-15 years. Participants were vaccinated w...
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| Format: | Article |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23240030/?tool=EBI |
| _version_ | 1818573263916236800 |
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| author | Sajjad Rafiq Margaret L Russell Richard Webby Kevin Fonseca Marek Smieja Pardeep Singh Mark Loeb |
| author_facet | Sajjad Rafiq Margaret L Russell Richard Webby Kevin Fonseca Marek Smieja Pardeep Singh Mark Loeb |
| author_sort | Sajjad Rafiq |
| collection | DOAJ |
| description | <h4>Background</h4>To evaluate if, among children aged 3 to 15 years, influenza vaccination for multiple seasons affects the proportion sero-protected.<h4>Methodology/principal findings</h4>Participants were 131 healthy children aged 3-15 years. Participants were vaccinated with trivalent inactivated seasonal influenza vaccine (TIV) over the 2005-06, 2006-07 and 2007-8 seasons. Number of seasons vaccinated were categorized as one (2007-08); two (2007-08 and 2006-07 or 2007-08 and 2005-06) or three (2005-06, 2006-07, and 2007-08). Pre- and post-vaccination sera were collected four weeks apart. Antibody titres were determined by hemagglutination inhibition (HAI) assay using antigens to A/Solomon Islands/03/06 (H1N1), A/Wisconsin/67/05 (H3N2) and B/Malaysia/2506/04. The proportions sero-protected were compared by number of seasons vaccinated using cut-points for seroprotection of 1:40 vs. 1:320. The proportions of children sero-protected against H1N1 and H3N2 was high (>85%) regardless of number of seasons vaccinated and regardless of cut-point for seroprotection. For B Malaysia there was no change in proportions sero-protected by number of seasons vaccinated; however the proportions protected were lower than for H1N1 and H3N2, and there was a lower proportion sero-protected when the higher, compared to lower, cut-point was used for sero-protection.<h4>Conclusion/significance</h4>The proportion of children sero-protected is not affected by number of seasons vaccinated. |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-15T00:08:51Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-05934a37c2e64ad6a6c05621a990fbfb2022-12-21T22:42:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01712e5149810.1371/journal.pone.0051498Serological response to influenza vaccination among children vaccinated for multiple influenza seasons.Sajjad RafiqMargaret L RussellRichard WebbyKevin FonsecaMarek SmiejaPardeep SinghMark Loeb<h4>Background</h4>To evaluate if, among children aged 3 to 15 years, influenza vaccination for multiple seasons affects the proportion sero-protected.<h4>Methodology/principal findings</h4>Participants were 131 healthy children aged 3-15 years. Participants were vaccinated with trivalent inactivated seasonal influenza vaccine (TIV) over the 2005-06, 2006-07 and 2007-8 seasons. Number of seasons vaccinated were categorized as one (2007-08); two (2007-08 and 2006-07 or 2007-08 and 2005-06) or three (2005-06, 2006-07, and 2007-08). Pre- and post-vaccination sera were collected four weeks apart. Antibody titres were determined by hemagglutination inhibition (HAI) assay using antigens to A/Solomon Islands/03/06 (H1N1), A/Wisconsin/67/05 (H3N2) and B/Malaysia/2506/04. The proportions sero-protected were compared by number of seasons vaccinated using cut-points for seroprotection of 1:40 vs. 1:320. The proportions of children sero-protected against H1N1 and H3N2 was high (>85%) regardless of number of seasons vaccinated and regardless of cut-point for seroprotection. For B Malaysia there was no change in proportions sero-protected by number of seasons vaccinated; however the proportions protected were lower than for H1N1 and H3N2, and there was a lower proportion sero-protected when the higher, compared to lower, cut-point was used for sero-protection.<h4>Conclusion/significance</h4>The proportion of children sero-protected is not affected by number of seasons vaccinated.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23240030/?tool=EBI |
| spellingShingle | Sajjad Rafiq Margaret L Russell Richard Webby Kevin Fonseca Marek Smieja Pardeep Singh Mark Loeb Serological response to influenza vaccination among children vaccinated for multiple influenza seasons. PLoS ONE |
| title | Serological response to influenza vaccination among children vaccinated for multiple influenza seasons. |
| title_full | Serological response to influenza vaccination among children vaccinated for multiple influenza seasons. |
| title_fullStr | Serological response to influenza vaccination among children vaccinated for multiple influenza seasons. |
| title_full_unstemmed | Serological response to influenza vaccination among children vaccinated for multiple influenza seasons. |
| title_short | Serological response to influenza vaccination among children vaccinated for multiple influenza seasons. |
| title_sort | serological response to influenza vaccination among children vaccinated for multiple influenza seasons |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23240030/?tool=EBI |
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