Aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairment
Aerobic training (AT) is a promising intervention to improve cognitive functioning. However, its modulatory effects on brain networks are not yet entirely understood. Sixty-five subjects with mild cognitive impairment performed a moderate intensity, 24-week AT program. Differences in resting regiona...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2018-01-01
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| Series: | NeuroImage: Clinical |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158218301487 |
| _version_ | 1823929224437694464 |
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| author | F.H.G. Porto Artur Martins Coutinho Fabio Luís de Souza Duran Ana Lucia de Sá Pinto Bruno Gualano Carlos Alberto Buchpiguel Geraldo Busatto Ricardo Nitrini Sonia Maria Dozzi Brucki |
| author_facet | F.H.G. Porto Artur Martins Coutinho Fabio Luís de Souza Duran Ana Lucia de Sá Pinto Bruno Gualano Carlos Alberto Buchpiguel Geraldo Busatto Ricardo Nitrini Sonia Maria Dozzi Brucki |
| author_sort | F.H.G. Porto |
| collection | DOAJ |
| description | Aerobic training (AT) is a promising intervention to improve cognitive functioning. However, its modulatory effects on brain networks are not yet entirely understood. Sixty-five subjects with mild cognitive impairment performed a moderate intensity, 24-week AT program. Differences in resting regional brain glucose metabolism (rBGM) with FDG-PET were assessed before and after AT on a voxel-by-voxel basis. Structural equation modeling was used to create latent variables based on regions with significant rBGM changes and to test a hypothetical model about the inter-relationships between these changes. There were significant rBGM reductions in both anterior temporal lobes (ATL), left inferior frontal gyrus, left anterior cingulate cortex, right hippocampus, left meddle frontal gyrus and bilateral caudate nuclei. In contrast, there was an increase in rBGM in the right precuneus and left inferior frontal gyrus. Latent variables reflecting the salience network and ATL were created, while the precuneus represented the default mode network. In the model, salience network rBGM was decreased after AT. In contrast, rBGM in the default mode network increased as a final outcome. This result suggested improved salience network efficacy and increased control over other brain functional networks. The ATL network decreased its rBGM and connected to the salience network and default mode network with positive and negative correlations, respectively. The model fit values reached statistical significance, demonstrating that this model explained the variance in the measured data. In mild cognitive impairment subjects, AT modulated rBGM in salience network and default mode network nodes. Such changes were in the direction of the normally expected resting-state metabolic patterns of these networks. Keywords: Mild cognitive impairment, Aerobic training, Salience network, Default mode network, FDG-PET, Non-pharmacological interventions, Structural equation modeling |
| first_indexed | 2024-12-16T21:06:38Z |
| format | Article |
| id | doaj.art-0594cd19dc0f43cc8d6254ccd16b125a |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-16T21:06:38Z |
| publishDate | 2018-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-0594cd19dc0f43cc8d6254ccd16b125a2022-12-21T22:16:18ZengElsevierNeuroImage: Clinical2213-15822018-01-0119616624Aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairmentF.H.G. Porto0Artur Martins Coutinho1Fabio Luís de Souza Duran2Ana Lucia de Sá Pinto3Bruno Gualano4Carlos Alberto Buchpiguel5Geraldo Busatto6Ricardo Nitrini7Sonia Maria Dozzi Brucki8Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Department of Neurology and Cognitive Disorders Reference Center (CEREDIC), São Paulo, SP, Brazil; Corresponding author at: CEREDIC - Centro de Referência em Distúrbios Cognitivos (CEREDIC), 206 Arruda Alvim st, Cerqueira César, São Paulo, SP 05419-020, Brazil.Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Department of Radiology, Nuclear Medicine Center (LIM43), São Paulo, SP, Brazil; Hospital Sírio-Libanês, São Paulo, BrazilHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Department of Psychiatry and LIM21, São Paulo, SP, BrazilHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Laboratory of Assessment and Conditioning in Rheumatology (LACRE), São Paulo, SP, BrazilHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Laboratory of Assessment and Conditioning in Rheumatology (LACRE), São Paulo, SP, BrazilHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Department of Radiology, Nuclear Medicine Center (LIM43), São Paulo, SP, BrazilHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Department of Psychiatry and LIM21, São Paulo, SP, BrazilHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Department of Neurology and Cognitive Disorders Reference Center (CEREDIC), São Paulo, SP, BrazilHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Department of Neurology and Cognitive Disorders Reference Center (CEREDIC), São Paulo, SP, BrazilAerobic training (AT) is a promising intervention to improve cognitive functioning. However, its modulatory effects on brain networks are not yet entirely understood. Sixty-five subjects with mild cognitive impairment performed a moderate intensity, 24-week AT program. Differences in resting regional brain glucose metabolism (rBGM) with FDG-PET were assessed before and after AT on a voxel-by-voxel basis. Structural equation modeling was used to create latent variables based on regions with significant rBGM changes and to test a hypothetical model about the inter-relationships between these changes. There were significant rBGM reductions in both anterior temporal lobes (ATL), left inferior frontal gyrus, left anterior cingulate cortex, right hippocampus, left meddle frontal gyrus and bilateral caudate nuclei. In contrast, there was an increase in rBGM in the right precuneus and left inferior frontal gyrus. Latent variables reflecting the salience network and ATL were created, while the precuneus represented the default mode network. In the model, salience network rBGM was decreased after AT. In contrast, rBGM in the default mode network increased as a final outcome. This result suggested improved salience network efficacy and increased control over other brain functional networks. The ATL network decreased its rBGM and connected to the salience network and default mode network with positive and negative correlations, respectively. The model fit values reached statistical significance, demonstrating that this model explained the variance in the measured data. In mild cognitive impairment subjects, AT modulated rBGM in salience network and default mode network nodes. Such changes were in the direction of the normally expected resting-state metabolic patterns of these networks. Keywords: Mild cognitive impairment, Aerobic training, Salience network, Default mode network, FDG-PET, Non-pharmacological interventions, Structural equation modelinghttp://www.sciencedirect.com/science/article/pii/S2213158218301487 |
| spellingShingle | F.H.G. Porto Artur Martins Coutinho Fabio Luís de Souza Duran Ana Lucia de Sá Pinto Bruno Gualano Carlos Alberto Buchpiguel Geraldo Busatto Ricardo Nitrini Sonia Maria Dozzi Brucki Aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairment NeuroImage: Clinical |
| title | Aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairment |
| title_full | Aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairment |
| title_fullStr | Aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairment |
| title_full_unstemmed | Aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairment |
| title_short | Aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairment |
| title_sort | aerobic training modulates salience network and default mode network metabolism in subjects with mild cognitive impairment |
| url | http://www.sciencedirect.com/science/article/pii/S2213158218301487 |
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