A comparison of low-dose teicoplanin-loaded spacer application vs. high-dose vancomycin-and-gentamicin-loaded spacer application in the treatment of periprosthetic knee infection
Background/purpose In the current study, our aim was to compare the efficacy and biocompatibility of teicoplanin-loaded and vancomycin-and-gentamicin-loaded articulating spacers used in two-stage revision arthroplasty for eradication of periprosthetic knee joint infection. Methods In the current ret...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-06-01
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| Series: | Journal of Orthopaedics, Trauma and Rehabilitation |
| Online Access: | https://doi.org/10.1177/22104917221082312 |
| _version_ | 1811309570203582464 |
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| author | Osman Cimen Ali Oner Alper Koksal Ferdi Dırvar Muhammed Mert Mümine Nursu Şahin Deniz Kargın |
| author_facet | Osman Cimen Ali Oner Alper Koksal Ferdi Dırvar Muhammed Mert Mümine Nursu Şahin Deniz Kargın |
| author_sort | Osman Cimen |
| collection | DOAJ |
| description | Background/purpose In the current study, our aim was to compare the efficacy and biocompatibility of teicoplanin-loaded and vancomycin-and-gentamicin-loaded articulating spacers used in two-stage revision arthroplasty for eradication of periprosthetic knee joint infection. Methods In the current retrospective cohort study, there were 24 patients who were given 2 g or less antibiotics per 40 g of cement in the low-dose teicoplanin group, and 20 patients who were given a total of 3.6 g or more antibiotics per 40 g of cement in the high-dose vancomycin and gentamicin group. Two groups were compared statistically. Results There was no statistically significant difference in the treatment failure between the two groups (p = 0.488). No statistically significant differences were found in spacer fracture rates between the two groups (p = 0.802). Conclusion The current study has demonstrated that low-dose teicoplanin protocol is as effective and safe as high-dose vancomycin and gentamycin protocol. |
| first_indexed | 2024-04-13T09:44:20Z |
| format | Article |
| id | doaj.art-0596ab9abec1424c987c87ecac2ca369 |
| institution | Directory Open Access Journal |
| issn | 2210-4925 |
| language | English |
| last_indexed | 2024-04-13T09:44:20Z |
| publishDate | 2022-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Orthopaedics, Trauma and Rehabilitation |
| spelling | doaj.art-0596ab9abec1424c987c87ecac2ca3692022-12-22T02:51:49ZengSAGE PublishingJournal of Orthopaedics, Trauma and Rehabilitation2210-49252022-06-012910.1177/22104917221082312A comparison of low-dose teicoplanin-loaded spacer application vs. high-dose vancomycin-and-gentamicin-loaded spacer application in the treatment of periprosthetic knee infectionOsman Cimen0Ali Oner1Alper Koksal2Ferdi Dırvar3Muhammed Mert4Mümine Nursu Şahin5Deniz Kargın6 Department of Orthopedics and Traumatology, , İstanbul, Turkey Department of Orthopedics and Traumatology, , İstanbul, Turkey Department of Orthopedics and Traumatology, , İstanbul, Turkey Department of Orthopedics and Traumatology, , İstanbul, Turkey Department of Orthopedics and Traumatology, , İstanbul, Turkey Department of Infection Diseases, , İstanbul, Turkey Department of Orthopedics and Traumatology, , İstanbul, TurkeyBackground/purpose In the current study, our aim was to compare the efficacy and biocompatibility of teicoplanin-loaded and vancomycin-and-gentamicin-loaded articulating spacers used in two-stage revision arthroplasty for eradication of periprosthetic knee joint infection. Methods In the current retrospective cohort study, there were 24 patients who were given 2 g or less antibiotics per 40 g of cement in the low-dose teicoplanin group, and 20 patients who were given a total of 3.6 g or more antibiotics per 40 g of cement in the high-dose vancomycin and gentamicin group. Two groups were compared statistically. Results There was no statistically significant difference in the treatment failure between the two groups (p = 0.488). No statistically significant differences were found in spacer fracture rates between the two groups (p = 0.802). Conclusion The current study has demonstrated that low-dose teicoplanin protocol is as effective and safe as high-dose vancomycin and gentamycin protocol.https://doi.org/10.1177/22104917221082312 |
| spellingShingle | Osman Cimen Ali Oner Alper Koksal Ferdi Dırvar Muhammed Mert Mümine Nursu Şahin Deniz Kargın A comparison of low-dose teicoplanin-loaded spacer application vs. high-dose vancomycin-and-gentamicin-loaded spacer application in the treatment of periprosthetic knee infection Journal of Orthopaedics, Trauma and Rehabilitation |
| title | A comparison of low-dose teicoplanin-loaded spacer application vs. high-dose vancomycin-and-gentamicin-loaded spacer application in the treatment of periprosthetic knee infection |
| title_full | A comparison of low-dose teicoplanin-loaded spacer application vs. high-dose vancomycin-and-gentamicin-loaded spacer application in the treatment of periprosthetic knee infection |
| title_fullStr | A comparison of low-dose teicoplanin-loaded spacer application vs. high-dose vancomycin-and-gentamicin-loaded spacer application in the treatment of periprosthetic knee infection |
| title_full_unstemmed | A comparison of low-dose teicoplanin-loaded spacer application vs. high-dose vancomycin-and-gentamicin-loaded spacer application in the treatment of periprosthetic knee infection |
| title_short | A comparison of low-dose teicoplanin-loaded spacer application vs. high-dose vancomycin-and-gentamicin-loaded spacer application in the treatment of periprosthetic knee infection |
| title_sort | comparison of low dose teicoplanin loaded spacer application vs high dose vancomycin and gentamicin loaded spacer application in the treatment of periprosthetic knee infection |
| url | https://doi.org/10.1177/22104917221082312 |
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