The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link?
Lately there are many new, promising low-density lipoprotein cholesterol reducing therapies with PCSK9 inhibitors. We performed selected sampling of the publications in PubMed and made a review according to selected keywords. It summarizes the effect of PCSK9 on vascular aging, directly associated w...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2019-10-01
|
| Series: | Polish Journal of Thoracic and Cardiovascular Surgery |
| Subjects: | |
| Online Access: | https://www.termedia.pl/The-role-of-proprotein-convertase-subtilisin-kexin-type-9-PCSK9-in-the-vascular-aging-process-is-there-a-link-,40,37944,1,1.html |
| _version_ | 1818305361229119488 |
|---|---|
| author | Malwina Grobelna Ewa Strauss Zbigniew Krasiński |
| author_facet | Malwina Grobelna Ewa Strauss Zbigniew Krasiński |
| author_sort | Malwina Grobelna |
| collection | DOAJ |
| description | Lately there are many new, promising low-density lipoprotein cholesterol reducing therapies with PCSK9 inhibitors. We performed selected sampling of the publications in PubMed and made a review according to selected keywords. It summarizes the effect of PCSK9 on vascular aging, directly associated with lipid and glucose metabolism, chronic inflammation, atherosclerosis and hypertension. Serum level of PCSK9 is different in patients affected by certain illnesses (whose risk increases with age) than in healthy individuals. The same could be observed in the case of chronic inflammation. In this review we summarize what is known about the role PCSK9 in human metabolism and how this could affect the vascular aging process. Based on the available sources, we prove that PCSK9 is involved in many biochemical pathways associated with vascular aging. In the future, treatments using PCSK9 inhibition may not only reduce the cardiovascular risk but also slow down this process. |
| first_indexed | 2024-12-13T06:25:22Z |
| format | Article |
| id | doaj.art-0598e6ab8ff04192a398ee07eb855b30 |
| institution | Directory Open Access Journal |
| issn | 1731-5530 1897-4252 |
| language | English |
| last_indexed | 2024-12-13T06:25:22Z |
| publishDate | 2019-10-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Polish Journal of Thoracic and Cardiovascular Surgery |
| spelling | doaj.art-0598e6ab8ff04192a398ee07eb855b302022-12-21T23:56:44ZengTermedia Publishing HousePolish Journal of Thoracic and Cardiovascular Surgery1731-55301897-42522019-10-0116312813210.5114/kitp.2019.8860237944The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link?Malwina GrobelnaEwa StraussZbigniew KrasińskiLately there are many new, promising low-density lipoprotein cholesterol reducing therapies with PCSK9 inhibitors. We performed selected sampling of the publications in PubMed and made a review according to selected keywords. It summarizes the effect of PCSK9 on vascular aging, directly associated with lipid and glucose metabolism, chronic inflammation, atherosclerosis and hypertension. Serum level of PCSK9 is different in patients affected by certain illnesses (whose risk increases with age) than in healthy individuals. The same could be observed in the case of chronic inflammation. In this review we summarize what is known about the role PCSK9 in human metabolism and how this could affect the vascular aging process. Based on the available sources, we prove that PCSK9 is involved in many biochemical pathways associated with vascular aging. In the future, treatments using PCSK9 inhibition may not only reduce the cardiovascular risk but also slow down this process.https://www.termedia.pl/The-role-of-proprotein-convertase-subtilisin-kexin-type-9-PCSK9-in-the-vascular-aging-process-is-there-a-link-,40,37944,1,1.htmlvascular aging pcsk9 atherosclerosis inflammation cholesterol |
| spellingShingle | Malwina Grobelna Ewa Strauss Zbigniew Krasiński The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link? Polish Journal of Thoracic and Cardiovascular Surgery vascular aging pcsk9 atherosclerosis inflammation cholesterol |
| title | The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link? |
| title_full | The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link? |
| title_fullStr | The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link? |
| title_full_unstemmed | The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link? |
| title_short | The role of proprotein convertase subtilisin-kexin type 9 (PCSK9) in the vascular aging process – is there a link? |
| title_sort | role of proprotein convertase subtilisin kexin type 9 pcsk9 in the vascular aging process is there a link |
| topic | vascular aging pcsk9 atherosclerosis inflammation cholesterol |
| url | https://www.termedia.pl/The-role-of-proprotein-convertase-subtilisin-kexin-type-9-PCSK9-in-the-vascular-aging-process-is-there-a-link-,40,37944,1,1.html |
| work_keys_str_mv | AT malwinagrobelna theroleofproproteinconvertasesubtilisinkexintype9pcsk9inthevascularagingprocessistherealink AT ewastrauss theroleofproproteinconvertasesubtilisinkexintype9pcsk9inthevascularagingprocessistherealink AT zbigniewkrasinski theroleofproproteinconvertasesubtilisinkexintype9pcsk9inthevascularagingprocessistherealink AT malwinagrobelna roleofproproteinconvertasesubtilisinkexintype9pcsk9inthevascularagingprocessistherealink AT ewastrauss roleofproproteinconvertasesubtilisinkexintype9pcsk9inthevascularagingprocessistherealink AT zbigniewkrasinski roleofproproteinconvertasesubtilisinkexintype9pcsk9inthevascularagingprocessistherealink |