Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early 1 gene.

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate early 1 gene.

The genomes of RNA and small DNA viruses of vertebrates display significant suppression of CpG dinucleotide frequencies. Artificially increasing dinucleotide frequencies results in substantial attenuation of virus replication, suggesting that these compositional changes may facilitate recognition of...

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Bibliographic Details
Main Authors: Yao-Tang Lin, Stephen Chiweshe, Dominique McCormick, Anna Raper, Arthur Wickenhagen, Victor DeFillipis, Eleanor Gaunt, Peter Simmonds, Sam J Wilson, Finn Grey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-09-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008844

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https://doi.org/10.1371/journal.ppat.1008844

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