Paternal high-fat diet alters triglyceride metabolism-related gene expression in liver and white adipose tissue of male mouse offspring
Obesity is a major public health problem, and its prevalence is progressively increasing worldwide. In addition, accumulating evidence suggests that diverse nutritional and metabolic disturbances including obesity can be transmitted from parents to offspring via transgenerational epigenetic inherita...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biochemistry and Biophysics Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580822001303 |
| _version_ | 1828758428290383872 |
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| author | Shu Aizawa Ai Tochihara Yutaka Yamamuro |
| author_facet | Shu Aizawa Ai Tochihara Yutaka Yamamuro |
| author_sort | Shu Aizawa |
| collection | DOAJ |
| description | Obesity is a major public health problem, and its prevalence is progressively increasing worldwide. In addition, accumulating evidence suggests that diverse nutritional and metabolic disturbances including obesity can be transmitted from parents to offspring via transgenerational epigenetic inheritance. The previous reports have shown that paternal obesity has profound impacts on the development and metabolic health of their progeny. However, little information is available concerning the effects of paternal high-fat diet (HFD) exposure on triglyceride metabolism in the offspring. Therefore, we investigated the effects of paternal HFD on triglyceride metabolism and related gene expression in male mouse offspring. We found that paternal HFD exposure significantly increased the body weight, liver and epididymal white adipose tissue (eWAT) weights, and liver triglyceride content in male offspring, despite consuming control diet. In addition, paternal HFD exposure had induced changes in the mRNA expression of genes involved in lipid and triglyceride metabolism in the liver and eWAT. These findings indicate transgenerational inheritance from the paternal metabolic disturbance of triglyceride and support the effects of paternal lifestyle choices on offspring development and health later in life. |
| first_indexed | 2024-12-11T00:41:43Z |
| format | Article |
| id | doaj.art-059c0c583c8e4aaea084df1f5c2c4397 |
| institution | Directory Open Access Journal |
| issn | 2405-5808 |
| language | English |
| last_indexed | 2024-12-11T00:41:43Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj.art-059c0c583c8e4aaea084df1f5c2c43972022-12-22T01:26:54ZengElsevierBiochemistry and Biophysics Reports2405-58082022-09-0131101330Paternal high-fat diet alters triglyceride metabolism-related gene expression in liver and white adipose tissue of male mouse offspringShu Aizawa0Ai Tochihara1Yutaka Yamamuro2Corresponding author. 1866 Kameino, Fujisawa, Kanagawa, 252-0880, Japan.; Laboratory of Animal Genetics and Physiology, Department of Animal Science, College of Bioresource Sciences, Nihon University, JapanLaboratory of Animal Genetics and Physiology, Department of Animal Science, College of Bioresource Sciences, Nihon University, JapanLaboratory of Animal Genetics and Physiology, Department of Animal Science, College of Bioresource Sciences, Nihon University, JapanObesity is a major public health problem, and its prevalence is progressively increasing worldwide. In addition, accumulating evidence suggests that diverse nutritional and metabolic disturbances including obesity can be transmitted from parents to offspring via transgenerational epigenetic inheritance. The previous reports have shown that paternal obesity has profound impacts on the development and metabolic health of their progeny. However, little information is available concerning the effects of paternal high-fat diet (HFD) exposure on triglyceride metabolism in the offspring. Therefore, we investigated the effects of paternal HFD on triglyceride metabolism and related gene expression in male mouse offspring. We found that paternal HFD exposure significantly increased the body weight, liver and epididymal white adipose tissue (eWAT) weights, and liver triglyceride content in male offspring, despite consuming control diet. In addition, paternal HFD exposure had induced changes in the mRNA expression of genes involved in lipid and triglyceride metabolism in the liver and eWAT. These findings indicate transgenerational inheritance from the paternal metabolic disturbance of triglyceride and support the effects of paternal lifestyle choices on offspring development and health later in life.http://www.sciencedirect.com/science/article/pii/S2405580822001303PaternalHigh-fat dietTriglyceride metabolismTransgenerational inheritance |
| spellingShingle | Shu Aizawa Ai Tochihara Yutaka Yamamuro Paternal high-fat diet alters triglyceride metabolism-related gene expression in liver and white adipose tissue of male mouse offspring Biochemistry and Biophysics Reports Paternal High-fat diet Triglyceride metabolism Transgenerational inheritance |
| title | Paternal high-fat diet alters triglyceride metabolism-related gene expression in liver and white adipose tissue of male mouse offspring |
| title_full | Paternal high-fat diet alters triglyceride metabolism-related gene expression in liver and white adipose tissue of male mouse offspring |
| title_fullStr | Paternal high-fat diet alters triglyceride metabolism-related gene expression in liver and white adipose tissue of male mouse offspring |
| title_full_unstemmed | Paternal high-fat diet alters triglyceride metabolism-related gene expression in liver and white adipose tissue of male mouse offspring |
| title_short | Paternal high-fat diet alters triglyceride metabolism-related gene expression in liver and white adipose tissue of male mouse offspring |
| title_sort | paternal high fat diet alters triglyceride metabolism related gene expression in liver and white adipose tissue of male mouse offspring |
| topic | Paternal High-fat diet Triglyceride metabolism Transgenerational inheritance |
| url | http://www.sciencedirect.com/science/article/pii/S2405580822001303 |
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