Pathologic Mechanisms of the Newcastle Disease Virus
Newcastle disease (ND) has been a consistent risk factor to the poultry industry worldwide. Its pathogen, Newcastle disease virus (NDV), is also a promising antitumor treatment candidate. The pathogenic mechanism has intrigued the great curiosity of researchers, and advances in the last two decades...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/4/864 |
| _version_ | 1827743416606261248 |
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| author | Di Zhang Zhuang Ding Xiaohong Xu |
| author_facet | Di Zhang Zhuang Ding Xiaohong Xu |
| author_sort | Di Zhang |
| collection | DOAJ |
| description | Newcastle disease (ND) has been a consistent risk factor to the poultry industry worldwide. Its pathogen, Newcastle disease virus (NDV), is also a promising antitumor treatment candidate. The pathogenic mechanism has intrigued the great curiosity of researchers, and advances in the last two decades have been summarized in this paper. The NDV’s pathogenic ability is highly related to the basic protein structure of the virus, which is described in the Introduction of this review. The overall clinical signs and recent findings pertaining to NDV-related lymph tissue damage are then described. Given the involvement of cytokines in the overall virulence of NDV, cytokines, particularly IL6 and IFN expressed during infection, are reviewed. On the other hand, the host also has its way of antagonizing the virus, which starts with the detection of the pathogen. Thus, advances in NDV’s physiological cell mechanism and the subsequent IFN response, autophagy, and apoptosis are summarized to provide a whole picture of the NDV infection process. |
| first_indexed | 2024-03-11T04:26:45Z |
| format | Article |
| id | doaj.art-059fcb26ad8a46e1b734d1a8365bc0ba |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T04:26:45Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-059fcb26ad8a46e1b734d1a8365bc0ba2023-11-17T21:44:51ZengMDPI AGViruses1999-49152023-03-0115486410.3390/v15040864Pathologic Mechanisms of the Newcastle Disease VirusDi Zhang0Zhuang Ding1Xiaohong Xu2Key Laboratory of Zoonosis Research, Ministry of Education, Jilin University, Changchun 130062, ChinaKey Laboratory of Zoonosis Research, Ministry of Education, Jilin University, Changchun 130062, ChinaKey Laboratory of Zoonosis Research, Ministry of Education, Jilin University, Changchun 130062, ChinaNewcastle disease (ND) has been a consistent risk factor to the poultry industry worldwide. Its pathogen, Newcastle disease virus (NDV), is also a promising antitumor treatment candidate. The pathogenic mechanism has intrigued the great curiosity of researchers, and advances in the last two decades have been summarized in this paper. The NDV’s pathogenic ability is highly related to the basic protein structure of the virus, which is described in the Introduction of this review. The overall clinical signs and recent findings pertaining to NDV-related lymph tissue damage are then described. Given the involvement of cytokines in the overall virulence of NDV, cytokines, particularly IL6 and IFN expressed during infection, are reviewed. On the other hand, the host also has its way of antagonizing the virus, which starts with the detection of the pathogen. Thus, advances in NDV’s physiological cell mechanism and the subsequent IFN response, autophagy, and apoptosis are summarized to provide a whole picture of the NDV infection process.https://www.mdpi.com/1999-4915/15/4/864Newcastle disease viruspathologic mechanismcytokinereceptorautophagyapoptosis |
| spellingShingle | Di Zhang Zhuang Ding Xiaohong Xu Pathologic Mechanisms of the Newcastle Disease Virus Viruses Newcastle disease virus pathologic mechanism cytokine receptor autophagy apoptosis |
| title | Pathologic Mechanisms of the Newcastle Disease Virus |
| title_full | Pathologic Mechanisms of the Newcastle Disease Virus |
| title_fullStr | Pathologic Mechanisms of the Newcastle Disease Virus |
| title_full_unstemmed | Pathologic Mechanisms of the Newcastle Disease Virus |
| title_short | Pathologic Mechanisms of the Newcastle Disease Virus |
| title_sort | pathologic mechanisms of the newcastle disease virus |
| topic | Newcastle disease virus pathologic mechanism cytokine receptor autophagy apoptosis |
| url | https://www.mdpi.com/1999-4915/15/4/864 |
| work_keys_str_mv | AT dizhang pathologicmechanismsofthenewcastlediseasevirus AT zhuangding pathologicmechanismsofthenewcastlediseasevirus AT xiaohongxu pathologicmechanismsofthenewcastlediseasevirus |