Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States
ABSTRACT Expression of the fission yeast Schizosaccharomyces pombe phosphate regulon is sensitive to the intracellular level of the inositol pyrophosphate signaling molecule 1,5-IP8. IP8 dynamics are determined by Asp1, a bifunctional enzyme consisting of an N-terminal kinase domain and a C-terminal...
Main Authors: | Bradley Benjamin, Yehuda Goldgur, Nikolaus Jork, Henning J. Jessen, Beate Schwer, Stewart Shuman |
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Format: | Article |
Language: | English |
Published: |
American Society for Microbiology
2022-12-01
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Series: | mBio |
Subjects: | |
Online Access: | https://journals.asm.org/doi/10.1128/mbio.03087-22 |
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