Sleep architecture in progressive supranuclear palsy: A video-polysomnography study
Background: Sleep disturbances have been reported to occur in progressive supranuclear palsy (PSP). The anatomical regions affected in PSP and those regulating sleep and wake cycle like dorsal raphe nucleus, locus coeruleus (LC), and pedunculopontine nucleus (PPN) overlap. There is a paucity of poly...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Annals of Indian Academy of Neurology |
| Subjects: | |
| Online Access: | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=5;spage=858;epage=863;aulast=Boini |
| _version_ | 1828093611655299072 |
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| author | Srikanth Yadav Boini Rohan Mahale Seshagiri Donaparthi Nitish Kamble Vikram V Holla Pramod Kumar Pal Bindu Kutty Ravi Yadav |
| author_facet | Srikanth Yadav Boini Rohan Mahale Seshagiri Donaparthi Nitish Kamble Vikram V Holla Pramod Kumar Pal Bindu Kutty Ravi Yadav |
| author_sort | Srikanth Yadav Boini |
| collection | DOAJ |
| description | Background: Sleep disturbances have been reported to occur in progressive supranuclear palsy (PSP). The anatomical regions affected in PSP and those regulating sleep and wake cycle like dorsal raphe nucleus, locus coeruleus (LC), and pedunculopontine nucleus (PPN) overlap. There is a paucity of polysomnographic studies in PSP and they have shown altered sleep architecture. Objective: To study the sleep architecture in patients with PSP using video-polysomnography (vPSG) and correlate it with the disease severity and duration. Methods: This was a prospective, cross-sectional, case-control, single-center study. A total of 22 patients with PSP and 15 age and gender-matched controls were recruited. The cases and controls underwent clinical assessment, face-to-face interviews with sleep questionnaires, anxiety and depression scales, and one overnight vPSG. The sleep architecture was analyzed in detail. Results: The sleep architecture was altered as compared to the controls. The total sleep time, stage N2 duration, stage N3 duration, rapid-eye-movement (REM) sleep duration, sleep efficiency %, and N2%, N3%, and REM% were significantly lesser in PSP patients. The wake duration, wake after sleep onset (WASO) duration, wake%, WASO%, stage N1 duration was significantly greater in PSP patients. The stage N2 and N3 latencies were significantly prolonged in patients. REM sleep without atonia was noted in four patients and no patients had vPSG proven REM sleep behavior disorder. Conclusions: Sleep architecture is altered in PSP even during the early stages of the disease. There is reduced total sleep including both non-REM and REM sleep, sleep efficiency, prolonged sleep latencies, and increased wake duration. This correlates with the neurodegenerative processes affecting the anatomical region regulating the sleep/wake cycle like dorsal raphe nucleus, locus coeruleus (LC), pedunculopontine nucleus (PPN). |
| first_indexed | 2024-04-11T06:46:28Z |
| format | Article |
| id | doaj.art-05a2f50108bf444d88ba0e88649c7159 |
| institution | Directory Open Access Journal |
| issn | 0972-2327 1998-3549 |
| language | English |
| last_indexed | 2024-04-11T06:46:28Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Annals of Indian Academy of Neurology |
| spelling | doaj.art-05a2f50108bf444d88ba0e88649c71592022-12-22T04:39:20ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492022-01-0125585886310.4103/aian.aian_1096_21Sleep architecture in progressive supranuclear palsy: A video-polysomnography studySrikanth Yadav BoiniRohan MahaleSeshagiri DonaparthiNitish KambleVikram V HollaPramod Kumar PalBindu KuttyRavi YadavBackground: Sleep disturbances have been reported to occur in progressive supranuclear palsy (PSP). The anatomical regions affected in PSP and those regulating sleep and wake cycle like dorsal raphe nucleus, locus coeruleus (LC), and pedunculopontine nucleus (PPN) overlap. There is a paucity of polysomnographic studies in PSP and they have shown altered sleep architecture. Objective: To study the sleep architecture in patients with PSP using video-polysomnography (vPSG) and correlate it with the disease severity and duration. Methods: This was a prospective, cross-sectional, case-control, single-center study. A total of 22 patients with PSP and 15 age and gender-matched controls were recruited. The cases and controls underwent clinical assessment, face-to-face interviews with sleep questionnaires, anxiety and depression scales, and one overnight vPSG. The sleep architecture was analyzed in detail. Results: The sleep architecture was altered as compared to the controls. The total sleep time, stage N2 duration, stage N3 duration, rapid-eye-movement (REM) sleep duration, sleep efficiency %, and N2%, N3%, and REM% were significantly lesser in PSP patients. The wake duration, wake after sleep onset (WASO) duration, wake%, WASO%, stage N1 duration was significantly greater in PSP patients. The stage N2 and N3 latencies were significantly prolonged in patients. REM sleep without atonia was noted in four patients and no patients had vPSG proven REM sleep behavior disorder. Conclusions: Sleep architecture is altered in PSP even during the early stages of the disease. There is reduced total sleep including both non-REM and REM sleep, sleep efficiency, prolonged sleep latencies, and increased wake duration. This correlates with the neurodegenerative processes affecting the anatomical region regulating the sleep/wake cycle like dorsal raphe nucleus, locus coeruleus (LC), pedunculopontine nucleus (PPN).http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=5;spage=858;epage=863;aulast=Boininon-rapid eye movement sleepprogressive supranuclear palsyrapid-eye movement sleepsleep durationsleep efficiency |
| spellingShingle | Srikanth Yadav Boini Rohan Mahale Seshagiri Donaparthi Nitish Kamble Vikram V Holla Pramod Kumar Pal Bindu Kutty Ravi Yadav Sleep architecture in progressive supranuclear palsy: A video-polysomnography study Annals of Indian Academy of Neurology non-rapid eye movement sleep progressive supranuclear palsy rapid-eye movement sleep sleep duration sleep efficiency |
| title | Sleep architecture in progressive supranuclear palsy: A video-polysomnography study |
| title_full | Sleep architecture in progressive supranuclear palsy: A video-polysomnography study |
| title_fullStr | Sleep architecture in progressive supranuclear palsy: A video-polysomnography study |
| title_full_unstemmed | Sleep architecture in progressive supranuclear palsy: A video-polysomnography study |
| title_short | Sleep architecture in progressive supranuclear palsy: A video-polysomnography study |
| title_sort | sleep architecture in progressive supranuclear palsy a video polysomnography study |
| topic | non-rapid eye movement sleep progressive supranuclear palsy rapid-eye movement sleep sleep duration sleep efficiency |
| url | http://www.annalsofian.org/article.asp?issn=0972-2327;year=2022;volume=25;issue=5;spage=858;epage=863;aulast=Boini |
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