Effect of Momordica charantia on the removal of arsenic from different organs of arsenic-treated rat
The present study was designed to examine the effect of Momordica charantia ethanol extract on the removal of arsenic from different organs of the arsenic-loaded rat. The rats (n=30) were divided into 5 groups: a) control, b) arsenic-treated (200 µg/L), c) extract-treated (50 mg/day), and d) arsenic...
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| Format: | Article |
| Language: | English |
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Bangabandhu Sheikh Mujib Medical University
2019-03-01
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| Series: | Bangabandhu Sheikh Mujib Medical University Journal |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BSMMUJ/article/view/40171 |
| _version_ | 1818807559664959488 |
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| author | Shakila Akhter Mir Misbahuddin |
| author_facet | Shakila Akhter Mir Misbahuddin |
| author_sort | Shakila Akhter |
| collection | DOAJ |
| description | The present study was designed to examine the effect of Momordica charantia ethanol extract on the removal of arsenic from different organs of the arsenic-loaded rat. The rats (n=30) were divided into 5 groups: a) control, b) arsenic-treated (200 µg/L), c) extract-treated (50 mg/day), and d) arsenic plus extract-treated (50 or 200 mg/kg). The rats were sacrificed on day 61. The study revealed that there were significant accumulation of arsenic in the liver, kidneys, intestine and skin. On the other hand, there was significant decrease in glutathione level in the liver. The administration of extract significantly decreased the amount of arsenic in all the organs tested and increased the glutathione level significantly in the liver. The maximum reduction of arsenic was found in skin (100%), liver (91.2%), intestine (89.2%) and kidney (83.1%). The maximum elevation of glutathione in liver was 48.3%. In conclusion, M. charantia reduces the arsenic level from different organs of the arsenic-loaded rat. |
| first_indexed | 2024-12-18T19:27:36Z |
| format | Article |
| id | doaj.art-05a5869ca9bf482b962a4db5ad894e6e |
| institution | Directory Open Access Journal |
| issn | 2074-2908 2224-7750 |
| language | English |
| last_indexed | 2024-12-18T19:27:36Z |
| publishDate | 2019-03-01 |
| publisher | Bangabandhu Sheikh Mujib Medical University |
| record_format | Article |
| series | Bangabandhu Sheikh Mujib Medical University Journal |
| spelling | doaj.art-05a5869ca9bf482b962a4db5ad894e6e2022-12-21T20:55:49ZengBangabandhu Sheikh Mujib Medical UniversityBangabandhu Sheikh Mujib Medical University Journal2074-29082224-77502019-03-0112110.3329/bsmmuj.v12i1.40171Effect of Momordica charantia on the removal of arsenic from different organs of arsenic-treated ratShakila Akhter0Mir Misbahuddin1Division of Arsenic Research, Department of Pharmacology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, BangladeshDepartment of Pharmacology, Faculty of Basic Science and Paraclinical Science, Bangabandhu Sheikh Mujib Medical University, Dhaka 1000The present study was designed to examine the effect of Momordica charantia ethanol extract on the removal of arsenic from different organs of the arsenic-loaded rat. The rats (n=30) were divided into 5 groups: a) control, b) arsenic-treated (200 µg/L), c) extract-treated (50 mg/day), and d) arsenic plus extract-treated (50 or 200 mg/kg). The rats were sacrificed on day 61. The study revealed that there were significant accumulation of arsenic in the liver, kidneys, intestine and skin. On the other hand, there was significant decrease in glutathione level in the liver. The administration of extract significantly decreased the amount of arsenic in all the organs tested and increased the glutathione level significantly in the liver. The maximum reduction of arsenic was found in skin (100%), liver (91.2%), intestine (89.2%) and kidney (83.1%). The maximum elevation of glutathione in liver was 48.3%. In conclusion, M. charantia reduces the arsenic level from different organs of the arsenic-loaded rat.https://www.banglajol.info/index.php/BSMMUJ/article/view/40171ArsenicArsenicosisLiverKidneyMomordica charantiaSkin |
| spellingShingle | Shakila Akhter Mir Misbahuddin Effect of Momordica charantia on the removal of arsenic from different organs of arsenic-treated rat Bangabandhu Sheikh Mujib Medical University Journal Arsenic Arsenicosis Liver Kidney Momordica charantia Skin |
| title | Effect of Momordica charantia on the removal of arsenic from different organs of arsenic-treated rat |
| title_full | Effect of Momordica charantia on the removal of arsenic from different organs of arsenic-treated rat |
| title_fullStr | Effect of Momordica charantia on the removal of arsenic from different organs of arsenic-treated rat |
| title_full_unstemmed | Effect of Momordica charantia on the removal of arsenic from different organs of arsenic-treated rat |
| title_short | Effect of Momordica charantia on the removal of arsenic from different organs of arsenic-treated rat |
| title_sort | effect of momordica charantia on the removal of arsenic from different organs of arsenic treated rat |
| topic | Arsenic Arsenicosis Liver Kidney Momordica charantia Skin |
| url | https://www.banglajol.info/index.php/BSMMUJ/article/view/40171 |
| work_keys_str_mv | AT shakilaakhter effectofmomordicacharantiaontheremovalofarsenicfromdifferentorgansofarsenictreatedrat AT mirmisbahuddin effectofmomordicacharantiaontheremovalofarsenicfromdifferentorgansofarsenictreatedrat |