Update on biomaterials for prevention of epidural adhesion after lumbar laminectomy
Summary: Lumbar laminectomy often results in failed back surgery syndrome. Most scholars support the three-dimensional theory of adhesion: Fibrosis surrounding the epidural tissues is based on the injured sacrospinalis behind, fibrous rings and posterior longitudinal ligaments. Approaches including...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2018-04-01
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| Series: | Journal of Orthopaedic Translation |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X17300979 |
| _version_ | 1811297469428924416 |
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| author | Huailan Wang Wenjia Sun Dongliang Fu Yueliang Shen Ying-ying Chen Lin-lin Wang |
| author_facet | Huailan Wang Wenjia Sun Dongliang Fu Yueliang Shen Ying-ying Chen Lin-lin Wang |
| author_sort | Huailan Wang |
| collection | DOAJ |
| description | Summary: Lumbar laminectomy often results in failed back surgery syndrome. Most scholars support the three-dimensional theory of adhesion: Fibrosis surrounding the epidural tissues is based on the injured sacrospinalis behind, fibrous rings and posterior longitudinal ligaments. Approaches including using the minimally invasive technique, drugs, biomaterial and nonbiomaterial barriers to prevent the postoperative epidural adhesion were intensively investigated. Nevertheless, the results are far from satisfactory. Our review is based on various implant biomaterials that are used in clinical applications or are under study. We show the advantages and disadvantages of each method. The summary will help us to figure out ideas towards new techniques.The translational potential of this article: This review summarises recent biomaterials-related clinical and basic research that focuses on prevention of epidural adhesion after lumbar laminectomy. We also propose a novel possible translational method where a soft scaffold acts as a physical barrier in the early stage, engineered adipose tissue acts as a biobarrier in the later stage in the application of biomaterials and adipose-derived mesenchymal stem cells are used for prevention of epidural adhesion. Keywords: Adhesion, Biomaterials, Fibrosis, Implant, Laminectomy |
| first_indexed | 2024-04-13T06:04:46Z |
| format | Article |
| id | doaj.art-05a606fad604492cb9fc948d33fbd279 |
| institution | Directory Open Access Journal |
| issn | 2214-031X |
| language | English |
| last_indexed | 2024-04-13T06:04:46Z |
| publishDate | 2018-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj.art-05a606fad604492cb9fc948d33fbd2792022-12-22T02:59:18ZengElsevierJournal of Orthopaedic Translation2214-031X2018-04-01134149Update on biomaterials for prevention of epidural adhesion after lumbar laminectomyHuailan Wang0Wenjia Sun1Dongliang Fu2Yueliang Shen3Ying-ying Chen4Lin-lin Wang5Department of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, ChinaDepartment of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, ChinaCorresponding author. Department of Basic Medicine Sciences, School of Medicine, Zhejiang University, Hangzhou 310058, China.; Department of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, ChinaSummary: Lumbar laminectomy often results in failed back surgery syndrome. Most scholars support the three-dimensional theory of adhesion: Fibrosis surrounding the epidural tissues is based on the injured sacrospinalis behind, fibrous rings and posterior longitudinal ligaments. Approaches including using the minimally invasive technique, drugs, biomaterial and nonbiomaterial barriers to prevent the postoperative epidural adhesion were intensively investigated. Nevertheless, the results are far from satisfactory. Our review is based on various implant biomaterials that are used in clinical applications or are under study. We show the advantages and disadvantages of each method. The summary will help us to figure out ideas towards new techniques.The translational potential of this article: This review summarises recent biomaterials-related clinical and basic research that focuses on prevention of epidural adhesion after lumbar laminectomy. We also propose a novel possible translational method where a soft scaffold acts as a physical barrier in the early stage, engineered adipose tissue acts as a biobarrier in the later stage in the application of biomaterials and adipose-derived mesenchymal stem cells are used for prevention of epidural adhesion. Keywords: Adhesion, Biomaterials, Fibrosis, Implant, Laminectomyhttp://www.sciencedirect.com/science/article/pii/S2214031X17300979 |
| spellingShingle | Huailan Wang Wenjia Sun Dongliang Fu Yueliang Shen Ying-ying Chen Lin-lin Wang Update on biomaterials for prevention of epidural adhesion after lumbar laminectomy Journal of Orthopaedic Translation |
| title | Update on biomaterials for prevention of epidural adhesion after lumbar laminectomy |
| title_full | Update on biomaterials for prevention of epidural adhesion after lumbar laminectomy |
| title_fullStr | Update on biomaterials for prevention of epidural adhesion after lumbar laminectomy |
| title_full_unstemmed | Update on biomaterials for prevention of epidural adhesion after lumbar laminectomy |
| title_short | Update on biomaterials for prevention of epidural adhesion after lumbar laminectomy |
| title_sort | update on biomaterials for prevention of epidural adhesion after lumbar laminectomy |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X17300979 |
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