Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae)
The EtOH extract from leaves of S. terebinthifolius was subjected to partition between EtOH:H2O and hexane, CH2Cl2, and EtOAc. The phases obtained were evaluated in vitro against human tumoral cell lines and the EtOAc phase exhibited activity. Chromatographic procedures afforded gallic acid (1), met...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2012-01-01
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| Series: | Química Nova |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100029&lng=en&tlng=en |
| _version_ | 1811195719857471488 |
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| author | Jeferson S. Santana Patricia Sartorelli João Henrique G. Lago Alisson L. Matsuo |
| author_facet | Jeferson S. Santana Patricia Sartorelli João Henrique G. Lago Alisson L. Matsuo |
| author_sort | Jeferson S. Santana |
| collection | DOAJ |
| description | The EtOH extract from leaves of S. terebinthifolius was subjected to partition between EtOH:H2O and hexane, CH2Cl2, and EtOAc. The phases obtained were evaluated in vitro against human tumoral cell lines and the EtOAc phase exhibited activity. Chromatographic procedures afforded gallic acid (1), methyl (2) and ethyl (3) gallates, trans-catechin (4), quercitrin (5), and afzelin (6), being the first occurrence of 1, 4 and 6 in S. terebinthifolius.In vitro cytotoxic evaluation of 1 - 6 indicated that gallic acid (1) displayed higher activity than ethyl gallate (3) against HL-60 and HeLa cells, while compounds 2, 4 - 6 were inactive. |
| first_indexed | 2024-04-12T00:47:46Z |
| format | Article |
| id | doaj.art-05a6b16787814c5bb808ac629b7c060c |
| institution | Directory Open Access Journal |
| issn | 1678-7064 |
| language | English |
| last_indexed | 2024-04-12T00:47:46Z |
| publishDate | 2012-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Química Nova |
| spelling | doaj.art-05a6b16787814c5bb808ac629b7c060c2022-12-22T03:54:49ZengSociedade Brasileira de QuímicaQuímica Nova1678-70642012-01-0135112245224810.1590/S0100-40422012001100029S0100-40422012001100029Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae)Jeferson S. Santana0Patricia Sartorelli1João Henrique G. Lago2Alisson L. Matsuo3Universidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloUniversidade Federal de São PauloThe EtOH extract from leaves of S. terebinthifolius was subjected to partition between EtOH:H2O and hexane, CH2Cl2, and EtOAc. The phases obtained were evaluated in vitro against human tumoral cell lines and the EtOAc phase exhibited activity. Chromatographic procedures afforded gallic acid (1), methyl (2) and ethyl (3) gallates, trans-catechin (4), quercitrin (5), and afzelin (6), being the first occurrence of 1, 4 and 6 in S. terebinthifolius.In vitro cytotoxic evaluation of 1 - 6 indicated that gallic acid (1) displayed higher activity than ethyl gallate (3) against HL-60 and HeLa cells, while compounds 2, 4 - 6 were inactive.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100029&lng=en&tlng=enSchinus terebinthifoliusphenolic derivativescytotoxic activity |
| spellingShingle | Jeferson S. Santana Patricia Sartorelli João Henrique G. Lago Alisson L. Matsuo Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae) Química Nova Schinus terebinthifolius phenolic derivatives cytotoxic activity |
| title | Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae) |
| title_full | Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae) |
| title_fullStr | Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae) |
| title_full_unstemmed | Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae) |
| title_short | Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae) |
| title_sort | isolamento e avaliacao do potencial citotoxico de derivados fenolicos de schinus terebinthifolius raddi anacardiaceae |
| topic | Schinus terebinthifolius phenolic derivatives cytotoxic activity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422012001100029&lng=en&tlng=en |
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