Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity

Functional and structural characteristics of HLA-B*13:01-mediated specific T cells reaction in dapsone-induced drug hypersensitivity

Abstract Background Severe cutaneous adverse drug reactions (SCARs) are a group of serious clinical conditions caused by immune reaction to certain drugs. The allelic variance of human leukocyte antigens of HLA-B*13:01 has been strongly associated with hypersensitivities induced by dapsone (DDS). T-...

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Bibliographic Details
Main Authors: Haiqin Jiang, Chuang-Wei Wang, Zhaoxi Wang, Yufei Dai, Yanping Zhu, Yun-Shien Lee, Yang Cao, Wen-Hung Chung, Songying Ouyang, Hongsheng Wang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Biomedical Science
Subjects:
Dapsone
Dapsone-induced hypersensitivity syndrome
HLA-B*13:01
T-cell receptor
Online Access:https://doi.org/10.1186/s12929-022-00845-8

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