Importance of Labarotory Parameters in Obstructive Sleep Apnea
Objective Obstructive sleep apnea (OSA) is associated with intermittent hypoxia. OSA leads to increased sympathetic activation, oxidative stress, vascular endothelial dysfunction, coagulation disorders and metabolic dysregulation. These disturbances increase the the risk of inflammation and cardiov...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Yayinevi
2016-03-01
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| Series: | Türk Uyku Tıbbı Dergisi |
| Subjects: | |
| Online Access: | http://jtsm.org/archives/archive-detail/article-preview/mportance-of-labarotory-parameters-in-obstructive-/11868 |
| _version_ | 1797913526017196032 |
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| author | Ebru Ortaç Ersoy Gülbahar Darilmaz Yüce Serap Duru Hikmet Firat Sadik Ardiç Bahar Kurt |
| author_facet | Ebru Ortaç Ersoy Gülbahar Darilmaz Yüce Serap Duru Hikmet Firat Sadik Ardiç Bahar Kurt |
| author_sort | Ebru Ortaç Ersoy |
| collection | DOAJ |
| description | Objective
Obstructive sleep apnea (OSA) is associated with intermittent hypoxia. OSA leads to increased sympathetic activation, oxidative stress, vascular endothelial dysfunction, coagulation disorders and metabolic dysregulation. These disturbances increase the the risk of inflammation and cardiovascular diseases. The purpose of this article is to review the laboratory parameters of OSA patients without any comorbidities.
Materials and Methods
This retrospective study of consecutive 675 patients who had polysomnography, was conducted on one hundred and thirty patients who did not have any comorbidities. Laboratory values of patients were evaluated. Patients were grouped according to apnea-hypopnea index (AHI). Group 1 (n=17) AHI <5; group 2 (n=42) AHI=5-14.9; group 3 (n=31) AHI=15-29.9 and group 4 (n=40) AHI >30.
Results
There were 88 men (67.7%) and 42 women (32.3%) in the study. Mean age, body mass index, Epworth score and AHI were 41.6±11.3 (16-75), 29.6±6.3 (17.1-65.7) 9.9±5.5, 6.2±11.34, respectively. Serum glucose, cholesterol and triglyceride levels were higher in group 4 (p=0.03, p=0.04, p=0.02, respectively). Uric acid and fibrinogen levels were higher in patients with higher AHI (p=0.038).
Conclusion
Our study indicates that increased blood glucose, uric acid and dyslipidemia are associated with OSA regardless of comorbidities. |
| first_indexed | 2024-04-10T12:13:05Z |
| format | Article |
| id | doaj.art-05a74220466a446fb3589af72a5b348f |
| institution | Directory Open Access Journal |
| issn | 2148-1504 |
| language | English |
| last_indexed | 2024-04-10T12:13:05Z |
| publishDate | 2016-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Türk Uyku Tıbbı Dergisi |
| spelling | doaj.art-05a74220466a446fb3589af72a5b348f2023-02-15T16:15:53ZengGalenos YayineviTürk Uyku Tıbbı Dergisi2148-15042016-03-01311510.4274/jtsm.2016.147Importance of Labarotory Parameters in Obstructive Sleep ApneaEbru Ortaç Ersoy0Gülbahar Darilmaz Yüce1Serap Duru2Hikmet Firat3Sadik Ardiç4Bahar Kurt5Hacettepe Üniversitesi Tip Fakültesi, Iç Hastaliklari Anabilim Dali, Yogun Bakim Bilim Dali, Ankara, TürkiyeTurgut Özal Üniversitesi Tip Fakültesi, Gögüs Hastaliklari Anabilim Dali, Ankara, TürkiyeDiskapi Yildirim Beyazit Egitim Ve Arastirma Hastanesi, Gögüs Hastaliklari Klinigi, Ankara, TürkiyeDiskapi Yildirim Beyazit Egitim Ve Arastirma Hastanesi, Gögüs Hastaliklari Klinigi, Ankara, TürkiyeDiskapi Yildirim Beyazit Egitim Ve Arastirma Hastanesi, Gögüs Hastaliklari Klinigi, Ankara, TürkiyeDiskapi Yildirim Beyazit Egitim Ve Arastirma Hastanesi, Gögüs Hastaliklari Klinigi, Ankara, TürkiyeObjective Obstructive sleep apnea (OSA) is associated with intermittent hypoxia. OSA leads to increased sympathetic activation, oxidative stress, vascular endothelial dysfunction, coagulation disorders and metabolic dysregulation. These disturbances increase the the risk of inflammation and cardiovascular diseases. The purpose of this article is to review the laboratory parameters of OSA patients without any comorbidities. Materials and Methods This retrospective study of consecutive 675 patients who had polysomnography, was conducted on one hundred and thirty patients who did not have any comorbidities. Laboratory values of patients were evaluated. Patients were grouped according to apnea-hypopnea index (AHI). Group 1 (n=17) AHI <5; group 2 (n=42) AHI=5-14.9; group 3 (n=31) AHI=15-29.9 and group 4 (n=40) AHI >30. Results There were 88 men (67.7%) and 42 women (32.3%) in the study. Mean age, body mass index, Epworth score and AHI were 41.6±11.3 (16-75), 29.6±6.3 (17.1-65.7) 9.9±5.5, 6.2±11.34, respectively. Serum glucose, cholesterol and triglyceride levels were higher in group 4 (p=0.03, p=0.04, p=0.02, respectively). Uric acid and fibrinogen levels were higher in patients with higher AHI (p=0.038). Conclusion Our study indicates that increased blood glucose, uric acid and dyslipidemia are associated with OSA regardless of comorbidities.http://jtsm.org/archives/archive-detail/article-preview/mportance-of-labarotory-parameters-in-obstructive-/11868Obstructive sleep apneaglucoseuric aciddyslipidemiafibrinogen |
| spellingShingle | Ebru Ortaç Ersoy Gülbahar Darilmaz Yüce Serap Duru Hikmet Firat Sadik Ardiç Bahar Kurt Importance of Labarotory Parameters in Obstructive Sleep Apnea Türk Uyku Tıbbı Dergisi Obstructive sleep apnea glucose uric acid dyslipidemia fibrinogen |
| title | Importance of Labarotory Parameters in Obstructive Sleep Apnea |
| title_full | Importance of Labarotory Parameters in Obstructive Sleep Apnea |
| title_fullStr | Importance of Labarotory Parameters in Obstructive Sleep Apnea |
| title_full_unstemmed | Importance of Labarotory Parameters in Obstructive Sleep Apnea |
| title_short | Importance of Labarotory Parameters in Obstructive Sleep Apnea |
| title_sort | importance of labarotory parameters in obstructive sleep apnea |
| topic | Obstructive sleep apnea glucose uric acid dyslipidemia fibrinogen |
| url | http://jtsm.org/archives/archive-detail/article-preview/mportance-of-labarotory-parameters-in-obstructive-/11868 |
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