Fast mutual exclusivity algorithm nominates potential synthetic lethal gene pairs through brute force matrix product computations

Fast mutual exclusivity algorithm nominates potential synthetic lethal gene pairs through brute force matrix product computations

Mutual Exclusivity analysis of genomic aberrations contributes to the exploration of potential synthetic lethal (SL) relationships thus guiding the nomination of specific cancer cells vulnerabilities. When multiple classes of genomic aberrations and large cohorts of patients are interrogated, exhaus...

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Detalles Bibliográficos
Main Authors: Tarcisio Fedrizzi, Yari Ciani, Francesca Lorenzin, Thomas Cantore, Paola Gasperini, Francesca Demichelis
Formato: Artigo
Idioma:English
Publicado: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Mutual exclusivity
Synthetic lethality
Cancer genomics
Computational genomics
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2001037021003329

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