Fast mutual exclusivity algorithm nominates potential synthetic lethal gene pairs through brute force matrix product computations

Fast mutual exclusivity algorithm nominates potential synthetic lethal gene pairs through brute force matrix product computations

Mutual Exclusivity analysis of genomic aberrations contributes to the exploration of potential synthetic lethal (SL) relationships thus guiding the nomination of specific cancer cells vulnerabilities. When multiple classes of genomic aberrations and large cohorts of patients are interrogated, exhaus...

Bibliografske podrobnosti
Main Authors:	Tarcisio Fedrizzi, Yari Ciani, Francesca Lorenzin, Thomas Cantore, Paola Gasperini, Francesca Demichelis
Format:	Article
Jezik:	English
Izdano:	Elsevier 2021-01-01
Serija:	Computational and Structural Biotechnology Journal
Teme:	Mutual exclusivity Synthetic lethality Cancer genomics Computational genomics
Online dostop:	http://www.sciencedirect.com/science/article/pii/S2001037021003329

Podobne knjige/članki

A Network-Centric Framework for the Evaluation of Mutual Exclusivity Tests on Cancer Drivers
od: Rafsan Ahmed, et al.
Izdano: (2021-11-01)

Application of social game context to teaching mutual exclusion
od: Miroslav Popović, et al.
Izdano: (2018-04-01)

Shared Mechanisms for Mutually Exclusive Expression and Antigenic Variation by Protozoan Parasites
od: Francesca Florini, et al.
Izdano: (2022-03-01)

The landscape of human mutually exclusive splicing
od: Klas Hatje, et al.
Izdano: (2017-12-01)

An $\Omega(n \log n)$ Lower Bound on the Cost of Mutual Exclusion
od: Fan, Rui, et al.
Izdano: (2008)

Synthetic Lethality in Lung Cancer—From the Perspective of Cancer Genomics
od: Iwao Shimomura, et al.
Izdano: (2019-03-01)

Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma
od: Arun M Unni, et al.
Izdano: (2015-06-01)

gcMECM: graph clustering of mutual exclusivity of cancer mutations
od: Ying Hu, et al.
Izdano: (2021-12-01)

Distributed Mutual Exclusion Algorithms for Intersection Traffic Problems
od: Harisu Abdullahi Shehu, et al.
Izdano: (2020-01-01)

Verifying Mutual Exclusion Algorithms with Non-Atomic Registers
od: Libero Nigro
Izdano: (2024-11-01)

A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy
od: Christopher Yogodzinski, et al.
Izdano: (2021-10-01)

Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells
od: Arun M Unni, et al.
Izdano: (2018-11-01)

Correctness Verification of Mutual Exclusion Algorithms by Model Checking
od: Libero Nigro, et al.
Izdano: (2024-06-01)

Modeling and Analysis of Dekker-Based Mutual Exclusion Algorithms
od: Libero Nigro, et al.
Izdano: (2024-05-01)

MIDESP: Mutual Information-Based Detection of Epistatic SNP Pairs for Qualitative and Quantitative Phenotypes
od: Felix Heinrich, et al.
Izdano: (2021-09-01)

Synthetic lethality and the minimal genome size problem
od: Sara Rahiminejad, et al.
Izdano: (2024-07-01)

Pan-Cancer Analysis of Potential Synthetic Lethal Drug Targets Specific to Alterations in DNA Damage Response
od: Shaoli Das, et al.
Izdano: (2019-10-01)

Conflicting Nature of Social-Pragmatic Cues with Mutual Exclusivity Regarding Three-Year-Olds’ Label-Referent Mappings
od: Yildiz Mustafa
Izdano: (2020-01-01)

A systematic survey to identify lethal recessive variation in highly managed pig populations
od: Martijn F. L. Derks, et al.
Izdano: (2017-11-01)

Role-Engineering Optimization with Cardinality Constraints and User-Oriented Mutually Exclusive Constraints
od: Wei Sun, et al.
Izdano: (2019-11-01)

Supervisor Synthesis for Multi-Agent Systems With Mutually Exclusive Resources
od: Huimin Zhang, et al.
Izdano: (2023-01-01)

Genome-wide scanning for candidate lethal genes associated with early embryonic mortality in Holstein dairy cattle
od: Somaye Rezaei, et al.
Izdano: (2025-03-01)

Co-occurrence and Mutual Exclusivity Analysis of DNA Methylation Reveals Distinct Subtypes in Multiple Cancers
od: Wubin Ding, et al.
Izdano: (2020-01-01)

Transcriptomic heterogeneity of driver gene mutations reveals novel mutual exclusivity and improves exploration of functional associations
od: Yujia Lan, et al.
Izdano: (2021-07-01)

One Function One Tool? A Review on Mutual Exclusivity in Tool Use Learning in Human and Non-human Species
od: Thuy Tuong Uyen Tran, et al.
Izdano: (2021-11-01)

Where’s the Advantage? Mutual Exclusivity Promotes Children’s Initial Mapping, but Not Long-Term Memory, for Words Compared to Other Strategies
od: Catherine A. Bredemann, et al.
Izdano: (2021-09-01)

SL-Cloud: A Cloud-based resource to support synthetic lethal interaction discovery [version 2; peer review: 2 approved]
od: William Longabaugh, et al.
Izdano: (2022-12-01)

Formal Modeling and Verification of Lycklama and Hadzilacos’s Mutual Exclusion Algorithm
od: Libero Nigro
Izdano: (2024-08-01)

Impact of host demography and evolutionary history on endosymbiont molecular evolution: A test in carpenter ants (genus Camponotus) and their Blochmannia endosymbionts
od: Joseph D. Manthey, et al.
Izdano: (2022-07-01)

Definition of a New Metric With Mutual Exclusivity and Coverage for Identifying Cancer Driver Modules
od: Wei Zhang, et al.
Izdano: (2020-01-01)

The biological essence of synthetic lethality: Bringing new opportunities for cancer therapy
od: Meiyi Ge, et al.
Izdano: (2024-03-01)

Testing the Process Dissociation Procedure by Behavioral and Neuroimaging Data: The Establishment of the Mutually Exclusive Theory and the Improved PDP
od: Jianxin Zhang, et al.
Izdano: (2020-11-01)

Genome‐scale gene/reaction essentiality and synthetic lethality analysis
od: Patrick F Suthers, et al.
Izdano: (2009-08-01)

Circumventing Zygotic Lethality to Generate Maternal Mutants in Zebrafish
od: De-Li Shi
Izdano: (2022-01-01)

Optimal Control of Colored Timed Petri Nets Under Generalized Mutual Exclusion Temporal Constraints
od: Kohei Fujita, et al.
Izdano: (2022-01-01)

Comparison of the lethal triad and the lethal diamond in severe trauma patients: a multicenter cohort
od: Charles Dupuy, et al.
Izdano: (2025-01-01)

Fighting Death for Living: Recent Advances in Molecular and Genetic Mechanisms Underlying Maize Lethal Necrosis Disease Resistance
od: Onyino Johnmark, et al.
Izdano: (2022-12-01)

Perinatal lethal osteogenesis imperfecta
od: Shahida Moosa
Izdano: (2012-11-01)

Genome analysis and genomic comparison of a fungal cultivar of the nonsocial weevil Euops chinensis reveals its plant decomposition and protective roles in fungus-farming mutualism
od: Wenfeng Guo, et al.
Izdano: (2023-02-01)

“They have their security, we have our community”: Mutual support among people experiencing homelessness in encampments in Toronto during the COVID-19 pandemic
od: Lisa M. Boucher, et al.
Izdano: (2022-12-01)