EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation
Breast cancer cells are known to metastasize to the bone but why the cells should migrate and metastasize to this particular organ is not clearly understood. Here, the authors show that EZH2 activates an integrin B1 and FAK signaling pathway in breast cancer cells, which activates TGFB signaling to...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30105-0 |
| _version_ | 1811235390045028352 |
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| author | Lin Zhang Jingkun Qu Yutao Qi Yimin Duan Yu-Wen Huang Zhifen Zhou Ping Li Jun Yao Beibei Huang Shuxing Zhang Dihua Yu |
| author_facet | Lin Zhang Jingkun Qu Yutao Qi Yimin Duan Yu-Wen Huang Zhifen Zhou Ping Li Jun Yao Beibei Huang Shuxing Zhang Dihua Yu |
| author_sort | Lin Zhang |
| collection | DOAJ |
| description | Breast cancer cells are known to metastasize to the bone but why the cells should migrate and metastasize to this particular organ is not clearly understood. Here, the authors show that EZH2 activates an integrin B1 and FAK signaling pathway in breast cancer cells, which activates TGFB signaling to drive metastasis in the bone. |
| first_indexed | 2024-04-12T11:51:09Z |
| format | Article |
| id | doaj.art-05aa232c6afd450daf8510c54d82f59b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T11:51:09Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-05aa232c6afd450daf8510c54d82f59b2022-12-22T03:34:10ZengNature PortfolioNature Communications2041-17232022-05-0113111610.1038/s41467-022-30105-0EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activationLin Zhang0Jingkun Qu1Yutao Qi2Yimin Duan3Yu-Wen Huang4Zhifen Zhou5Ping Li6Jun Yao7Beibei Huang8Shuxing Zhang9Dihua Yu10Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterIntelligent Molecular Discovery Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer CenterMD Anderson Cancer Center UTHealth Graduate School of Biomedical SciencesDepartment of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer CenterBreast cancer cells are known to metastasize to the bone but why the cells should migrate and metastasize to this particular organ is not clearly understood. Here, the authors show that EZH2 activates an integrin B1 and FAK signaling pathway in breast cancer cells, which activates TGFB signaling to drive metastasis in the bone.https://doi.org/10.1038/s41467-022-30105-0 |
| spellingShingle | Lin Zhang Jingkun Qu Yutao Qi Yimin Duan Yu-Wen Huang Zhifen Zhou Ping Li Jun Yao Beibei Huang Shuxing Zhang Dihua Yu EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation Nature Communications |
| title | EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation |
| title_full | EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation |
| title_fullStr | EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation |
| title_full_unstemmed | EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation |
| title_short | EZH2 engages TGFβ signaling to promote breast cancer bone metastasis via integrin β1-FAK activation |
| title_sort | ezh2 engages tgfβ signaling to promote breast cancer bone metastasis via integrin β1 fak activation |
| url | https://doi.org/10.1038/s41467-022-30105-0 |
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