HWJMSC-EVs promote cartilage regeneration and repair via the ITGB1/TGF-β/Smad2/3 axis mediated by microfractures

HWJMSC-EVs promote cartilage regeneration and repair via the ITGB1/TGF-β/Smad2/3 axis mediated by microfractures

Abstract The current first-line treatment for repairing cartilage defects in clinical practice is the creation of microfractures (MF) to stimulate the release of mesenchymal stem cells (MSCs); however, this method has many limitations. Recent studies have found that MSC-derived extracellular vesicle...

Full description

Bibliographic Details
Main Authors: Zhian Chen, Tianhua Zhou, Huan Luo, Zhen Wang, Qiang Wang, Rongmao Shi, Zian Li, Rongqing Pang, Hongbo Tan
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Nanobiotechnology
Subjects:
Chondrocytes
Regeneration
Microfractures
Human Wharton’s jelly MSCs
Extracellular vesicles
Online Access:https://doi.org/10.1186/s12951-024-02451-2

Internet

https://doi.org/10.1186/s12951-024-02451-2

Similar Items