Cytologic Phenotypes of B-Cell Acute Lymphoblastic Leukemia-
Acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid precursor cells, which could be classified according to morphological and cytochemical methods as well as immunophenotyping. Twenty patients with ALL, who had been referred to the Children's Medical Center Hospital, during...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2009-06-01
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| Series: | Iranian Journal of Allergy, Asthma and Immunology |
| Subjects: | |
| Online Access: | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/241 |
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| author | Ramyar Asghar Shafiei Masoud Rezaei Nima Asgarian-Omran Hossein Abdar Esfahani Shadi Moazzami Kasra Sarafnejad Abdolfattah Aghamohammadi Asghar |
| author_facet | Ramyar Asghar Shafiei Masoud Rezaei Nima Asgarian-Omran Hossein Abdar Esfahani Shadi Moazzami Kasra Sarafnejad Abdolfattah Aghamohammadi Asghar |
| author_sort | Ramyar Asghar |
| collection | DOAJ |
| description | Acute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid precursor cells, which could be classified according to morphological and cytochemical methods as well as immunophenotyping.
Twenty patients with ALL, who had been referred to the Children's Medical Center Hospital, during the year 2007, were enrolled in this study in order to evaluate the morphologic and immunophenotypic profile of these patients.
Cytologic analysis of blood and bone marrow samples revealed that the frequency of ALL-L1 was 70%, followed by ALL-L2 and ALL-L3. The onset age of the patients with ALL-L1 was significantly lower than the patients with L2/L3. Severe anemia was significantly detected more in L1 group. Flow cytometic study of bone marrow showed that 10 cases had Pre-B1 ALL and 7 cases had Pre-B2 ALL, while three cases had Pro-B ALL. Comparisons of the characteristics and clinical manifestations among these groups did not show any appreciable difference. There were an increase percentage of CD20+ cells and a decrease CD10+ cells in pre-B2 group in comparison with pre-B1 group. Fifteen patients were in standard risk and five were in high risk. Although standard risk patients were more common in the group of pre-B1, this was not significant.
Our results confirm the previous reports indicating heterogeneity of ALL. Immunophenotyping is not the only diagnostic test of importance, while morphological assessment still can be used in the diagnosis and classification of the disease. |
| first_indexed | 2024-12-14T02:40:07Z |
| format | Article |
| id | doaj.art-05ad22b98fee4109aecbb7079d8104bd |
| institution | Directory Open Access Journal |
| issn | 1735-1502 1735-5249 |
| language | English |
| last_indexed | 2024-12-14T02:40:07Z |
| publishDate | 2009-06-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Allergy, Asthma and Immunology |
| spelling | doaj.art-05ad22b98fee4109aecbb7079d8104bd2022-12-21T23:20:02ZengTehran University of Medical SciencesIranian Journal of Allergy, Asthma and Immunology1735-15021735-52492009-06-0182241Cytologic Phenotypes of B-Cell Acute Lymphoblastic Leukemia-Ramyar Asghar0Shafiei Masoud1 Rezaei Nima2Asgarian-Omran Hossein3Abdar Esfahani Shadi4Moazzami Kasra5Sarafnejad Abdolfattah6Aghamohammadi Asghar7Department of Hematology and Oncology of Children's Medical Center, Tehran University of Medical SciDepartment of Hematology and Oncology of Children's Medical Center, Tehran University of Medical SciImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IrDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IrDepartment of Hematology and Oncology of Children's Medical Center, Tehran University of Medical Sciof Hematology and Oncology of Children's Medical Center, Tehran University of Medical Sciences, TehrDepartment of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, IrImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, IrAcute lymphoblastic leukemia (ALL) is a malignant disorder of lymphoid precursor cells, which could be classified according to morphological and cytochemical methods as well as immunophenotyping. Twenty patients with ALL, who had been referred to the Children's Medical Center Hospital, during the year 2007, were enrolled in this study in order to evaluate the morphologic and immunophenotypic profile of these patients. Cytologic analysis of blood and bone marrow samples revealed that the frequency of ALL-L1 was 70%, followed by ALL-L2 and ALL-L3. The onset age of the patients with ALL-L1 was significantly lower than the patients with L2/L3. Severe anemia was significantly detected more in L1 group. Flow cytometic study of bone marrow showed that 10 cases had Pre-B1 ALL and 7 cases had Pre-B2 ALL, while three cases had Pro-B ALL. Comparisons of the characteristics and clinical manifestations among these groups did not show any appreciable difference. There were an increase percentage of CD20+ cells and a decrease CD10+ cells in pre-B2 group in comparison with pre-B1 group. Fifteen patients were in standard risk and five were in high risk. Although standard risk patients were more common in the group of pre-B1, this was not significant. Our results confirm the previous reports indicating heterogeneity of ALL. Immunophenotyping is not the only diagnostic test of importance, while morphological assessment still can be used in the diagnosis and classification of the disease.https://ijaai.tums.ac.ir/index.php/ijaai/article/view/241Acute lymphoblastic leukemiaImmunophenotypingMorphology |
| spellingShingle | Ramyar Asghar Shafiei Masoud Rezaei Nima Asgarian-Omran Hossein Abdar Esfahani Shadi Moazzami Kasra Sarafnejad Abdolfattah Aghamohammadi Asghar Cytologic Phenotypes of B-Cell Acute Lymphoblastic Leukemia- Iranian Journal of Allergy, Asthma and Immunology Acute lymphoblastic leukemia Immunophenotyping Morphology |
| title | Cytologic Phenotypes of B-Cell Acute Lymphoblastic Leukemia- |
| title_full | Cytologic Phenotypes of B-Cell Acute Lymphoblastic Leukemia- |
| title_fullStr | Cytologic Phenotypes of B-Cell Acute Lymphoblastic Leukemia- |
| title_full_unstemmed | Cytologic Phenotypes of B-Cell Acute Lymphoblastic Leukemia- |
| title_short | Cytologic Phenotypes of B-Cell Acute Lymphoblastic Leukemia- |
| title_sort | cytologic phenotypes of b cell acute lymphoblastic leukemia |
| topic | Acute lymphoblastic leukemia Immunophenotyping Morphology |
| url | https://ijaai.tums.ac.ir/index.php/ijaai/article/view/241 |
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