Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology
Arginine methylation mediated by protein arginine methyltransferases (PRMTs) is a post-translational modification of both histone and non-histone substrates related to diverse biological processes. PRMTs appear to be critical regulators in skeletal muscle physiology, including regeneration, metaboli...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-08-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.712389/full |
| _version_ | 1831572193156268032 |
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| author | Hyun-Kyung So Hyun-Kyung So Sunghee Kim Jong-Sun Kang Sang-Jin Lee |
| author_facet | Hyun-Kyung So Hyun-Kyung So Sunghee Kim Jong-Sun Kang Sang-Jin Lee |
| author_sort | Hyun-Kyung So |
| collection | DOAJ |
| description | Arginine methylation mediated by protein arginine methyltransferases (PRMTs) is a post-translational modification of both histone and non-histone substrates related to diverse biological processes. PRMTs appear to be critical regulators in skeletal muscle physiology, including regeneration, metabolic homeostasis, and plasticity. Chronic inflammation is commonly associated with the decline of skeletal muscle mass and strength related to aging or chronic diseases, defined as sarcopenia. In turn, declined skeletal muscle mass and strength can exacerbate chronic inflammation. Thus, understanding the molecular regulatory pathway underlying the crosstalk between skeletal muscle function and inflammation might be essential for the intervention of muscle pathophysiology. In this review, we will address the current knowledge on the role of PRMTs in skeletal muscle physiology and pathophysiology with a specific emphasis on its relationship with inflammation. |
| first_indexed | 2024-12-17T13:23:01Z |
| format | Article |
| id | doaj.art-05ad3bca9e8240f8b668208760add76c |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-17T13:23:01Z |
| publishDate | 2021-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-05ad3bca9e8240f8b668208760add76c2022-12-21T21:46:49ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-08-011210.3389/fphys.2021.712389712389Role of Protein Arginine Methyltransferases and Inflammation in Muscle PathophysiologyHyun-Kyung So0Hyun-Kyung So1Sunghee Kim2Jong-Sun Kang3Sang-Jin Lee4Molecular Cell Biology, Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South KoreaResearch Institute of Aging-Related Disease, AniMusCure Inc., Suwon, South KoreaMolecular Cell Biology, Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South KoreaMolecular Cell Biology, Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, South KoreaResearch Institute of Aging-Related Disease, AniMusCure Inc., Suwon, South KoreaArginine methylation mediated by protein arginine methyltransferases (PRMTs) is a post-translational modification of both histone and non-histone substrates related to diverse biological processes. PRMTs appear to be critical regulators in skeletal muscle physiology, including regeneration, metabolic homeostasis, and plasticity. Chronic inflammation is commonly associated with the decline of skeletal muscle mass and strength related to aging or chronic diseases, defined as sarcopenia. In turn, declined skeletal muscle mass and strength can exacerbate chronic inflammation. Thus, understanding the molecular regulatory pathway underlying the crosstalk between skeletal muscle function and inflammation might be essential for the intervention of muscle pathophysiology. In this review, we will address the current knowledge on the role of PRMTs in skeletal muscle physiology and pathophysiology with a specific emphasis on its relationship with inflammation.https://www.frontiersin.org/articles/10.3389/fphys.2021.712389/fullmusclePRMTsinflammationcytokineinflammation-related muscle diseasemyokine |
| spellingShingle | Hyun-Kyung So Hyun-Kyung So Sunghee Kim Jong-Sun Kang Sang-Jin Lee Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology Frontiers in Physiology muscle PRMTs inflammation cytokine inflammation-related muscle disease myokine |
| title | Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology |
| title_full | Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology |
| title_fullStr | Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology |
| title_full_unstemmed | Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology |
| title_short | Role of Protein Arginine Methyltransferases and Inflammation in Muscle Pathophysiology |
| title_sort | role of protein arginine methyltransferases and inflammation in muscle pathophysiology |
| topic | muscle PRMTs inflammation cytokine inflammation-related muscle disease myokine |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.712389/full |
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