The risk factors involved in airway mucus plug in children with ADV Pneumonia
Abstract Background The risk factors for mucus plug in children with adenovirus (ADV) pneumonia. Methods and materials A retrospective analysis was conducted of children diagnosed ADV pneumonia and underwent fiberoptic bronchoscopy admitted to the Xiamen Children's Hospital from September 2018...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-023-02756-2 |
| _version_ | 1797578434360115200 |
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| author | Jing-jing Huang Lin Yuan Zhi-qiang Zhuo Ming-zhen Li Xing-dong Wu |
| author_facet | Jing-jing Huang Lin Yuan Zhi-qiang Zhuo Ming-zhen Li Xing-dong Wu |
| author_sort | Jing-jing Huang |
| collection | DOAJ |
| description | Abstract Background The risk factors for mucus plug in children with adenovirus (ADV) pneumonia. Methods and materials A retrospective analysis was conducted of children diagnosed ADV pneumonia and underwent fiberoptic bronchoscopy admitted to the Xiamen Children's Hospital from September 2018 to September 2021.The patients were divided into a mucus plug group (39 cases) and a non-mucus plug group (53 cases). The children's data including sex, age, clinical presentation, laboratory test parameters, imaging and bronchoscopic data were collected. The risk factors for the development of airway mucus plug were analysed by multifactorial logistic regression. Results There were no statistically significant differences in sex, age, fever, hospitalization days, mixed infection, white blood cells (WBC) count, percentage of neutrophils (NE%), C-reactive protein(CRP), and D-dimer (all P > 0.05); Thermal range, procalcitonin (PCT), lactate dehydrogenase (LDH), Pleural effusion and associated decreased breath sounds was significantly higher in mucus plug group than in non-mucus plug group, and the differences were statistically significant (all P < 0.05); multifactorial logistic regression analysis showed that the duration of fever, PCT, and LDH were independent risk factors for the formation of mucus plugs. The critical values of ROC curves were pyroprocedure ≥ 6.5 d, PCT ≥ 0.705 ng/ml and LDH ≥ 478.5 U/L. Conclusion Duration of fever, PCT and LDH levels were the independent risk factors for the formation of an airway mucus plug in children with ADV pneumonia. |
| first_indexed | 2024-03-10T22:21:51Z |
| format | Article |
| id | doaj.art-05ad5e0a826242b2b07aece09be9c920 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-03-10T22:21:51Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-05ad5e0a826242b2b07aece09be9c9202023-11-19T12:14:23ZengBMCBMC Pulmonary Medicine1471-24662023-11-012311810.1186/s12890-023-02756-2The risk factors involved in airway mucus plug in children with ADV PneumoniaJing-jing Huang0Lin Yuan1Zhi-qiang Zhuo2Ming-zhen Li3Xing-dong Wu4Department of Infection, Xiamen Children’s Hospital (Children’s Hospital of Fudan University at Xiamen)Department of Infection, Xiamen Children’s Hospital (Children’s Hospital of Fudan University at Xiamen)Department of Infection, Xiamen Children’s Hospital (Children’s Hospital of Fudan University at Xiamen)Department of Infection, Xiamen Children’s Hospital (Children’s Hospital of Fudan University at Xiamen)Department of Infection, Xiamen Children’s Hospital (Children’s Hospital of Fudan University at Xiamen)Abstract Background The risk factors for mucus plug in children with adenovirus (ADV) pneumonia. Methods and materials A retrospective analysis was conducted of children diagnosed ADV pneumonia and underwent fiberoptic bronchoscopy admitted to the Xiamen Children's Hospital from September 2018 to September 2021.The patients were divided into a mucus plug group (39 cases) and a non-mucus plug group (53 cases). The children's data including sex, age, clinical presentation, laboratory test parameters, imaging and bronchoscopic data were collected. The risk factors for the development of airway mucus plug were analysed by multifactorial logistic regression. Results There were no statistically significant differences in sex, age, fever, hospitalization days, mixed infection, white blood cells (WBC) count, percentage of neutrophils (NE%), C-reactive protein(CRP), and D-dimer (all P > 0.05); Thermal range, procalcitonin (PCT), lactate dehydrogenase (LDH), Pleural effusion and associated decreased breath sounds was significantly higher in mucus plug group than in non-mucus plug group, and the differences were statistically significant (all P < 0.05); multifactorial logistic regression analysis showed that the duration of fever, PCT, and LDH were independent risk factors for the formation of mucus plugs. The critical values of ROC curves were pyroprocedure ≥ 6.5 d, PCT ≥ 0.705 ng/ml and LDH ≥ 478.5 U/L. Conclusion Duration of fever, PCT and LDH levels were the independent risk factors for the formation of an airway mucus plug in children with ADV pneumonia.https://doi.org/10.1186/s12890-023-02756-2Adenovirus pneumoniaChildrenFibreoptic bronchoscopyMucus plugRisk factors |
| spellingShingle | Jing-jing Huang Lin Yuan Zhi-qiang Zhuo Ming-zhen Li Xing-dong Wu The risk factors involved in airway mucus plug in children with ADV Pneumonia BMC Pulmonary Medicine Adenovirus pneumonia Children Fibreoptic bronchoscopy Mucus plug Risk factors |
| title | The risk factors involved in airway mucus plug in children with ADV Pneumonia |
| title_full | The risk factors involved in airway mucus plug in children with ADV Pneumonia |
| title_fullStr | The risk factors involved in airway mucus plug in children with ADV Pneumonia |
| title_full_unstemmed | The risk factors involved in airway mucus plug in children with ADV Pneumonia |
| title_short | The risk factors involved in airway mucus plug in children with ADV Pneumonia |
| title_sort | risk factors involved in airway mucus plug in children with adv pneumonia |
| topic | Adenovirus pneumonia Children Fibreoptic bronchoscopy Mucus plug Risk factors |
| url | https://doi.org/10.1186/s12890-023-02756-2 |
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