Interaction of some essential amino acids with synthesized poorly crystalline hydroxyapatite
This study focused on the release of two essential amino acids, l-lysine and dl-leucine, previously adsorbed onto poorly crystalline hydroxyapatite of Ca/P = 1.59, synthesis by precipitation methods. The composition of the calcium-deficient hydroxyapatite (CDHA) is chemically and structurally simila...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-09-01
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| Series: | Journal of Saudi Chemical Society |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319610313000550 |
| _version_ | 1818854282483466240 |
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| author | A. El Rhilassi M. Mourabet M. Bennani-Ziatni R. El Hamri A. Taitai |
| author_facet | A. El Rhilassi M. Mourabet M. Bennani-Ziatni R. El Hamri A. Taitai |
| author_sort | A. El Rhilassi |
| collection | DOAJ |
| description | This study focused on the release of two essential amino acids, l-lysine and dl-leucine, previously adsorbed onto poorly crystalline hydroxyapatite of Ca/P = 1.59, synthesis by precipitation methods. The composition of the calcium-deficient hydroxyapatite (CDHA) is chemically and structurally similar to the bone mineral. Their surface reactivity is indeed linked to the existence of hydrated surface particles (HPO42- and Ca2+). The adsorption kinetics is very fast while the release kinetics is relatively slow. The adsorption rate reached approximately 70%, but the release rate did not exceed 12%. The chemical composition of solution has an influence on the release processes. The presence of phosphate ions favored the release of amino acids, while the calcium ions inhibited it. Also, the release process is slightly influenced by Ra (ml/mg) ratio and incubation temperature of the medium. The charged –COO− and NH3+ of amino acids are the strongest groups that interact with the surface of hydroxyapatite, the adsorption is mainly due to the electrostatic interaction between the groups –COO− of amino acids and calcium Ca2+ ions of the hydroxyapatite. dl-Leucine (non-polar) and l-Lysine (polar–basic) interact with the hydroxyapatite surface in the zwitterionic and cationic forms, respectively. The study of interactions between amino acids and hydroxyapatite is carried out in vitro by using UV–vis and infrared spectroscopy IR techniques. |
| first_indexed | 2024-12-19T07:50:14Z |
| format | Article |
| id | doaj.art-05ad99ffcf6a4079b54b08c2985502d9 |
| institution | Directory Open Access Journal |
| issn | 1319-6103 |
| language | English |
| last_indexed | 2024-12-19T07:50:14Z |
| publishDate | 2016-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Saudi Chemical Society |
| spelling | doaj.art-05ad99ffcf6a4079b54b08c2985502d92022-12-21T20:30:10ZengElsevierJournal of Saudi Chemical Society1319-61032016-09-0120S1S632S64010.1016/j.jscs.2013.05.003Interaction of some essential amino acids with synthesized poorly crystalline hydroxyapatiteA. El RhilassiM. MourabetM. Bennani-ZiatniR. El HamriA. TaitaiThis study focused on the release of two essential amino acids, l-lysine and dl-leucine, previously adsorbed onto poorly crystalline hydroxyapatite of Ca/P = 1.59, synthesis by precipitation methods. The composition of the calcium-deficient hydroxyapatite (CDHA) is chemically and structurally similar to the bone mineral. Their surface reactivity is indeed linked to the existence of hydrated surface particles (HPO42- and Ca2+). The adsorption kinetics is very fast while the release kinetics is relatively slow. The adsorption rate reached approximately 70%, but the release rate did not exceed 12%. The chemical composition of solution has an influence on the release processes. The presence of phosphate ions favored the release of amino acids, while the calcium ions inhibited it. Also, the release process is slightly influenced by Ra (ml/mg) ratio and incubation temperature of the medium. The charged –COO− and NH3+ of amino acids are the strongest groups that interact with the surface of hydroxyapatite, the adsorption is mainly due to the electrostatic interaction between the groups –COO− of amino acids and calcium Ca2+ ions of the hydroxyapatite. dl-Leucine (non-polar) and l-Lysine (polar–basic) interact with the hydroxyapatite surface in the zwitterionic and cationic forms, respectively. The study of interactions between amino acids and hydroxyapatite is carried out in vitro by using UV–vis and infrared spectroscopy IR techniques.http://www.sciencedirect.com/science/article/pii/S1319610313000550HydroxyapatiteAdsorptionReleaseAmino acidMedium compositionElectrostatic interaction |
| spellingShingle | A. El Rhilassi M. Mourabet M. Bennani-Ziatni R. El Hamri A. Taitai Interaction of some essential amino acids with synthesized poorly crystalline hydroxyapatite Journal of Saudi Chemical Society Hydroxyapatite Adsorption Release Amino acid Medium composition Electrostatic interaction |
| title | Interaction of some essential amino acids with synthesized poorly crystalline hydroxyapatite |
| title_full | Interaction of some essential amino acids with synthesized poorly crystalline hydroxyapatite |
| title_fullStr | Interaction of some essential amino acids with synthesized poorly crystalline hydroxyapatite |
| title_full_unstemmed | Interaction of some essential amino acids with synthesized poorly crystalline hydroxyapatite |
| title_short | Interaction of some essential amino acids with synthesized poorly crystalline hydroxyapatite |
| title_sort | interaction of some essential amino acids with synthesized poorly crystalline hydroxyapatite |
| topic | Hydroxyapatite Adsorption Release Amino acid Medium composition Electrostatic interaction |
| url | http://www.sciencedirect.com/science/article/pii/S1319610313000550 |
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