Molecular mechanisms of microRNA-216a during tumor progression
Abstract MicroRNAs (miRNAs) as the members of non-coding RNAs family are involved in post-transcriptional regulation by translational inhibiting or mRNA degradation. They have a critical role in regulation of cell proliferation and migration. MiRNAs aberrations have been reported in various cancers....
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-023-02865-2 |
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| author | Amir Abbas Hamidi Negin Taghehchian Amir Sadra Zangouei Iman Akhlaghipour Amirhosein Maharati Zahra Basirat Meysam Moghbeli |
| author_facet | Amir Abbas Hamidi Negin Taghehchian Amir Sadra Zangouei Iman Akhlaghipour Amirhosein Maharati Zahra Basirat Meysam Moghbeli |
| author_sort | Amir Abbas Hamidi |
| collection | DOAJ |
| description | Abstract MicroRNAs (miRNAs) as the members of non-coding RNAs family are involved in post-transcriptional regulation by translational inhibiting or mRNA degradation. They have a critical role in regulation of cell proliferation and migration. MiRNAs aberrations have been reported in various cancers. Considering the importance of these factors in regulation of cellular processes and their high stability in body fluids, these factors can be suggested as suitable non-invasive markers for the cancer diagnosis. MiR-216a deregulation has been frequently reported in different cancers. Therefore, in the present review we discussed the molecular mechanisms of the miR-216a during tumor progression. It has been reported that miR-216a mainly functioned as a tumor suppressor through the regulation of signaling pathways and transcription factors. This review paves the way to suggest the miR-216a as a probable therapeutic and diagnostic target in cancer patients. |
| first_indexed | 2024-04-10T17:15:45Z |
| format | Article |
| id | doaj.art-05af8955cc874765a29e1f1a557fb082 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-04-10T17:15:45Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-05af8955cc874765a29e1f1a557fb0822023-02-05T12:24:25ZengBMCCancer Cell International1475-28672023-02-0123111810.1186/s12935-023-02865-2Molecular mechanisms of microRNA-216a during tumor progressionAmir Abbas Hamidi0Negin Taghehchian1Amir Sadra Zangouei2Iman Akhlaghipour3Amirhosein Maharati4Zahra Basirat5Meysam Moghbeli6Student Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesMedical Genetics Research Center, Mashhad University of Medical SciencesStudent Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesStudent Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesStudent Research Committee, Faculty of Medicine, Mashhad University of Medical SciencesMedical Genetics Research Center, Mashhad University of Medical SciencesMedical Genetics Research Center, Mashhad University of Medical SciencesAbstract MicroRNAs (miRNAs) as the members of non-coding RNAs family are involved in post-transcriptional regulation by translational inhibiting or mRNA degradation. They have a critical role in regulation of cell proliferation and migration. MiRNAs aberrations have been reported in various cancers. Considering the importance of these factors in regulation of cellular processes and their high stability in body fluids, these factors can be suggested as suitable non-invasive markers for the cancer diagnosis. MiR-216a deregulation has been frequently reported in different cancers. Therefore, in the present review we discussed the molecular mechanisms of the miR-216a during tumor progression. It has been reported that miR-216a mainly functioned as a tumor suppressor through the regulation of signaling pathways and transcription factors. This review paves the way to suggest the miR-216a as a probable therapeutic and diagnostic target in cancer patients.https://doi.org/10.1186/s12935-023-02865-2MicroRNA-216aDiagnosisPrognosisCancerMarkerTreatment |
| spellingShingle | Amir Abbas Hamidi Negin Taghehchian Amir Sadra Zangouei Iman Akhlaghipour Amirhosein Maharati Zahra Basirat Meysam Moghbeli Molecular mechanisms of microRNA-216a during tumor progression Cancer Cell International MicroRNA-216a Diagnosis Prognosis Cancer Marker Treatment |
| title | Molecular mechanisms of microRNA-216a during tumor progression |
| title_full | Molecular mechanisms of microRNA-216a during tumor progression |
| title_fullStr | Molecular mechanisms of microRNA-216a during tumor progression |
| title_full_unstemmed | Molecular mechanisms of microRNA-216a during tumor progression |
| title_short | Molecular mechanisms of microRNA-216a during tumor progression |
| title_sort | molecular mechanisms of microrna 216a during tumor progression |
| topic | MicroRNA-216a Diagnosis Prognosis Cancer Marker Treatment |
| url | https://doi.org/10.1186/s12935-023-02865-2 |
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