Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis compared
Background: Cholesterol is derived via de novo synthesis and dietary absorption. Both processes can be monitored by determination of non-cholesterol sterol concentrations (lathosterol for synthesis; sitosterol and campesterol for absorption). The hypocholesterolemia that occurs during acute illness...
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| Format: | Article |
| Language: | English |
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Palacký University Olomouc, Faculty of Medicine and Dentistry
2019-09-01
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| Series: | Biomedical Papers |
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| Online Access: | https://biomed.papers.upol.cz/artkey/bio-201903-0010_changes-in-cholesterol-metabolism-during-acute-upper-gastrointestinal-bleeding-liver-cirrhosis-and-non-cirrhos.php |
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| author | Vladimir Hrabovsky Vladimir Blaha Radomir Hyspler Alena Ticha Martina Skrobankova Zdenek Svagera |
| author_facet | Vladimir Hrabovsky Vladimir Blaha Radomir Hyspler Alena Ticha Martina Skrobankova Zdenek Svagera |
| author_sort | Vladimir Hrabovsky |
| collection | DOAJ |
| description | Background: Cholesterol is derived via de novo synthesis and dietary absorption. Both processes can be monitored by determination of non-cholesterol sterol concentrations (lathosterol for synthesis; sitosterol and campesterol for absorption). The hypocholesterolemia that occurs during acute illness is a result of a multifactorial inability to compensate for the increased needs for this metabolite. The aim of this study was to examine the plasma cholesterol profile and both processes of cholesterol acquisition during acute upper gastrointestinal haemorrhage with emphasis on liver cirrhosis. Material and Methods: Thirty five patients with acute upper gastrointestinal bleeding (cirrhosis n=14, non-cirrhosis n=21) were evaluated over a 6 day period. The control cohort consisted of 100 blood donors. Serum concentrations of total, LDL (low-density lipoprotein) and HDL (high-density lipoprotein) cholesterol were measured enzymatically. Sterol concentrations were analysed using gas chromatography, data were statistically analysed. Results: In all patients, we found lower plasma levels of total cholesterol (P Conclusion: Our results showed substantial abnormalities in the cholesterol plasma profile including both the processes of cholesterol acquisition in patients with upper acute gastrointestinal bleeding. The patients with or without liver cirrhosis had similar trends in cholesterol plasma levels. Depression of cholesterol synthesis was, however, prolonged in the cirrhotic group and the data also suggest a different phytosterol metabolism. |
| first_indexed | 2024-12-11T00:16:44Z |
| format | Article |
| id | doaj.art-05b0275065a543ce8fb4037d16014e8a |
| institution | Directory Open Access Journal |
| issn | 1213-8118 1804-7521 |
| language | English |
| last_indexed | 2024-12-11T00:16:44Z |
| publishDate | 2019-09-01 |
| publisher | Palacký University Olomouc, Faculty of Medicine and Dentistry |
| record_format | Article |
| series | Biomedical Papers |
| spelling | doaj.art-05b0275065a543ce8fb4037d16014e8a2022-12-22T01:27:55ZengPalacký University Olomouc, Faculty of Medicine and DentistryBiomedical Papers1213-81181804-75212019-09-01163325325810.5507/bp.2018.055bio-201903-0010Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis comparedVladimir Hrabovsky0Vladimir Blaha1Radomir Hyspler2Alena Ticha3Martina Skrobankova4Zdenek Svagera5Intensive Care Unit, Department of Internal Medicine, University Hospital Ostrava, Czech RepublicDepartment of Metabolic Care and Gerontology, University Hospital Hradec Kralove, Czech RepublicDepartment of Metabolic Care and Gerontology, University Hospital Hradec Kralove, Czech RepublicDepartment of Metabolic Care and Gerontology, University Hospital Hradec Kralove, Czech RepublicIntensive Care Unit, Department of Internal Medicine, University Hospital Ostrava, Czech RepublicDepartment of Clinical Biochemistry, University Hospital Ostrava, Czech RepublicBackground: Cholesterol is derived via de novo synthesis and dietary absorption. Both processes can be monitored by determination of non-cholesterol sterol concentrations (lathosterol for synthesis; sitosterol and campesterol for absorption). The hypocholesterolemia that occurs during acute illness is a result of a multifactorial inability to compensate for the increased needs for this metabolite. The aim of this study was to examine the plasma cholesterol profile and both processes of cholesterol acquisition during acute upper gastrointestinal haemorrhage with emphasis on liver cirrhosis. Material and Methods: Thirty five patients with acute upper gastrointestinal bleeding (cirrhosis n=14, non-cirrhosis n=21) were evaluated over a 6 day period. The control cohort consisted of 100 blood donors. Serum concentrations of total, LDL (low-density lipoprotein) and HDL (high-density lipoprotein) cholesterol were measured enzymatically. Sterol concentrations were analysed using gas chromatography, data were statistically analysed. Results: In all patients, we found lower plasma levels of total cholesterol (P Conclusion: Our results showed substantial abnormalities in the cholesterol plasma profile including both the processes of cholesterol acquisition in patients with upper acute gastrointestinal bleeding. The patients with or without liver cirrhosis had similar trends in cholesterol plasma levels. Depression of cholesterol synthesis was, however, prolonged in the cirrhotic group and the data also suggest a different phytosterol metabolism.https://biomed.papers.upol.cz/artkey/bio-201903-0010_changes-in-cholesterol-metabolism-during-acute-upper-gastrointestinal-bleeding-liver-cirrhosis-and-non-cirrhos.phpacute gastrointestinal bleedinglipidscholesterolhypocholesterolemianon-cholesterol sterolsphytosterolsliver cirrhosis |
| spellingShingle | Vladimir Hrabovsky Vladimir Blaha Radomir Hyspler Alena Ticha Martina Skrobankova Zdenek Svagera Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis compared Biomedical Papers acute gastrointestinal bleeding lipids cholesterol hypocholesterolemia non-cholesterol sterols phytosterols liver cirrhosis |
| title | Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis compared |
| title_full | Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis compared |
| title_fullStr | Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis compared |
| title_full_unstemmed | Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis compared |
| title_short | Changes in cholesterol metabolism during acute upper gastrointestinal bleeding: liver cirrhosis and non cirrhosis compared |
| title_sort | changes in cholesterol metabolism during acute upper gastrointestinal bleeding liver cirrhosis and non cirrhosis compared |
| topic | acute gastrointestinal bleeding lipids cholesterol hypocholesterolemia non-cholesterol sterols phytosterols liver cirrhosis |
| url | https://biomed.papers.upol.cz/artkey/bio-201903-0010_changes-in-cholesterol-metabolism-during-acute-upper-gastrointestinal-bleeding-liver-cirrhosis-and-non-cirrhos.php |
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