Efficacy of nicotine-replacement therapy, bupropion, and a combination of both for treating nicotine addiction: a randomized clinical trial
Background Most of the studies about the efficacy of smoking-cessation medication and its side effects were conducted in developed countries on participants who differ from Arab population in sociocultural and genetic factors. Patients and methods A randomized controlled trial was conducted on a con...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2022;volume=71;issue=1;spage=51;epage=58;aulast=Abdelghany |
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| author | Dalia A Abdelghany Nesrien Mohammad Shalabi Amina Mahmoud Abd-El-Maksoud Wafaa Abd El-Hakim El-Bahaey Marwa Salah El-Dahan Nesrine S Farrag Tamer Ali Elhadidy |
| author_facet | Dalia A Abdelghany Nesrien Mohammad Shalabi Amina Mahmoud Abd-El-Maksoud Wafaa Abd El-Hakim El-Bahaey Marwa Salah El-Dahan Nesrine S Farrag Tamer Ali Elhadidy |
| author_sort | Dalia A Abdelghany |
| collection | DOAJ |
| description | Background Most of the studies about the efficacy of smoking-cessation medication and its side effects were conducted in developed countries on participants who differ from Arab population in sociocultural and genetic factors.
Patients and methods A randomized controlled trial was conducted on a convenient sample of 100 smokers at the smoking-cessation clinic. The participants were allocated into four groups: nicotine-replacement therapy (NRT), bupropion (BPP), combination of NRT+BPP, and placebo. Counseling was offered to all participants. Outcomes: self-reported smoking status with biochemical verification (success to stop smoking, lapse, relapse, or failure to stop smoking) at 3 and 6 months from starting treatment.
Results The total success rate in four studied groups was 14% at 3 months and 8% at 6 months. There was no evidence of any statistically significant difference between any of the interventional groups (NRT, BPP, or their combination) and placebo group at 3 and 6 months as regards success rate (8, 12, 8, and 28%, respectively, at 3 months and 8, 12, 0, and 12%, respectively, at 6 months). There were no serious adverse events in the studied groups. Headache was more significantly reported by placebo group compared with all other groups (P=0.01), and urgency was more significantly reported by placebo group compared with NRT group (P=0.001).
Conclusion The study found no evidence of the superior effect of NRT, BPP, or their combination over placebo in helping smokers quit smoking at 3 and 6 months. However, more withdrawal symptoms were reported by the placebo group. |
| first_indexed | 2024-04-11T17:24:08Z |
| format | Article |
| id | doaj.art-05b03642379e48cbb431e183390c29e3 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 2090-9950 |
| language | English |
| last_indexed | 2024-04-11T17:24:08Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-05b03642379e48cbb431e183390c29e32022-12-22T04:12:23ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382090-99502022-01-01711515810.4103/ecdt.ecdt_15_21Efficacy of nicotine-replacement therapy, bupropion, and a combination of both for treating nicotine addiction: a randomized clinical trialDalia A AbdelghanyNesrien Mohammad ShalabiAmina Mahmoud Abd-El-MaksoudWafaa Abd El-Hakim El-BahaeyMarwa Salah El-DahanNesrine S FarragTamer Ali ElhadidyBackground Most of the studies about the efficacy of smoking-cessation medication and its side effects were conducted in developed countries on participants who differ from Arab population in sociocultural and genetic factors. Patients and methods A randomized controlled trial was conducted on a convenient sample of 100 smokers at the smoking-cessation clinic. The participants were allocated into four groups: nicotine-replacement therapy (NRT), bupropion (BPP), combination of NRT+BPP, and placebo. Counseling was offered to all participants. Outcomes: self-reported smoking status with biochemical verification (success to stop smoking, lapse, relapse, or failure to stop smoking) at 3 and 6 months from starting treatment. Results The total success rate in four studied groups was 14% at 3 months and 8% at 6 months. There was no evidence of any statistically significant difference between any of the interventional groups (NRT, BPP, or their combination) and placebo group at 3 and 6 months as regards success rate (8, 12, 8, and 28%, respectively, at 3 months and 8, 12, 0, and 12%, respectively, at 6 months). There were no serious adverse events in the studied groups. Headache was more significantly reported by placebo group compared with all other groups (P=0.01), and urgency was more significantly reported by placebo group compared with NRT group (P=0.001). Conclusion The study found no evidence of the superior effect of NRT, BPP, or their combination over placebo in helping smokers quit smoking at 3 and 6 months. However, more withdrawal symptoms were reported by the placebo group.http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2022;volume=71;issue=1;spage=51;epage=58;aulast=Abdelghanybupropionnicotine addictionnicotine-replacement therapysmoking cessationsmoking lapse |
| spellingShingle | Dalia A Abdelghany Nesrien Mohammad Shalabi Amina Mahmoud Abd-El-Maksoud Wafaa Abd El-Hakim El-Bahaey Marwa Salah El-Dahan Nesrine S Farrag Tamer Ali Elhadidy Efficacy of nicotine-replacement therapy, bupropion, and a combination of both for treating nicotine addiction: a randomized clinical trial Egyptian Journal of Chest Disease and Tuberculosis bupropion nicotine addiction nicotine-replacement therapy smoking cessation smoking lapse |
| title | Efficacy of nicotine-replacement therapy, bupropion, and a combination of both for treating nicotine addiction: a randomized clinical trial |
| title_full | Efficacy of nicotine-replacement therapy, bupropion, and a combination of both for treating nicotine addiction: a randomized clinical trial |
| title_fullStr | Efficacy of nicotine-replacement therapy, bupropion, and a combination of both for treating nicotine addiction: a randomized clinical trial |
| title_full_unstemmed | Efficacy of nicotine-replacement therapy, bupropion, and a combination of both for treating nicotine addiction: a randomized clinical trial |
| title_short | Efficacy of nicotine-replacement therapy, bupropion, and a combination of both for treating nicotine addiction: a randomized clinical trial |
| title_sort | efficacy of nicotine replacement therapy bupropion and a combination of both for treating nicotine addiction a randomized clinical trial |
| topic | bupropion nicotine addiction nicotine-replacement therapy smoking cessation smoking lapse |
| url | http://www.ejcdt.eg.net/article.asp?issn=0422-7638;year=2022;volume=71;issue=1;spage=51;epage=58;aulast=Abdelghany |
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