Nicolau syndrome after intramuscular benzathine penicillin injection
Background: Nicolau syndrome is a rare, potentially severe complication that may occur after any drug injection, particularly after intramuscular, subcutaneous or intraarticular injection. The pathogenesis of the necrosis is not completely known, it's presumed that ischemic necrosis is induced...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | Journal of Pediatric Surgery Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213576620302311 |
| _version_ | 1818663956336607232 |
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| author | Yapo Guy serge Kouamé Jean Baptiste Yaokreh Moufidath Sounkeré Samba Tembely Idalia Taguela Ajoumissi Koffi Eric N'goran Audrey Helene Thomas Koudou Thiery Hervé Odehouri Dibi Bertin Kouamé Ossenou Ouattara |
| author_facet | Yapo Guy serge Kouamé Jean Baptiste Yaokreh Moufidath Sounkeré Samba Tembely Idalia Taguela Ajoumissi Koffi Eric N'goran Audrey Helene Thomas Koudou Thiery Hervé Odehouri Dibi Bertin Kouamé Ossenou Ouattara |
| author_sort | Yapo Guy serge Kouamé |
| collection | DOAJ |
| description | Background: Nicolau syndrome is a rare, potentially severe complication that may occur after any drug injection, particularly after intramuscular, subcutaneous or intraarticular injection. The pathogenesis of the necrosis is not completely known, it's presumed that ischemic necrosis is induced by direct vascular injury, perivascular inflammation, and vascular constriction. Few case was reported since the first description by Freudenthal in 1924 and Nicolau in 1925. Case report: we report two cases of Nicolau syndrome in the child after benzathine penicillin intramuscular injection in the thigh. The cases were complicated by a necrosis of the extremities and a Volkmann syndrome. Conclusion: Nicolau syndrome is an uncommon iatrogenic ischemic necrosis of the skin and deeper tissue. It is reported to occur after intramuscular injection for certain drugs such as benzathine penicillin. The pathogenesis is unknown but embolic occlusion, inflammatory and physical obstruction of blood vessels have been suggested in our cases. There is no standard guideline for its management. |
| first_indexed | 2024-12-17T05:25:05Z |
| format | Article |
| id | doaj.art-05b13576b54748f2a7c46f7563b01816 |
| institution | Directory Open Access Journal |
| issn | 2213-5766 |
| language | English |
| last_indexed | 2024-12-17T05:25:05Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pediatric Surgery Case Reports |
| spelling | doaj.art-05b13576b54748f2a7c46f7563b018162022-12-21T22:01:53ZengElsevierJournal of Pediatric Surgery Case Reports2213-57662021-01-0164101597Nicolau syndrome after intramuscular benzathine penicillin injectionYapo Guy serge Kouamé0Jean Baptiste Yaokreh1Moufidath Sounkeré2Samba Tembely3Idalia Taguela Ajoumissi4Koffi Eric N'goran5Audrey Helene Thomas6Koudou Thiery Hervé Odehouri7Dibi Bertin Kouamé8Ossenou Ouattara9Pediatric Surgery, University Hospital Yopougon, Abidjan, Ivory Coast; Pediatric Surgery Hospital Yopougon, Departement of Surgery, University of Felix Houphouët Boigny, Ivory Coast; Corresponding author. Pediatric Surgery Hospital Yopougon, Abidjan, 21 BP 632, Abidjan 21, Ivory Coast.Pediatric Surgery, University Hospital Yopougon, Abidjan, Ivory Coast; Pediatric Surgery Hospital Yopougon, Departement of Surgery, University of Felix Houphouët Boigny, Ivory CoastPediatric Surgery, University Hospital Yopougon, Abidjan, Ivory Coast; Pediatric Surgery Hospital Yopougon, Departement of Surgery, University of Felix Houphouët Boigny, Ivory CoastPediatric Surgery, University Hospital Yopougon, Abidjan, Ivory CoastPediatric Surgery, University Hospital Yopougon, Abidjan, Ivory CoastPediatric Surgery, University Hospital Yopougon, Abidjan, Ivory Coast; Pediatric Surgery Hospital Yopougon, Departement of Surgery, University of Felix Houphouët Boigny, Ivory CoastPediatric Surgery, University Hospital Yopougon, Abidjan, Ivory Coast; Pediatric Surgery Hospital Yopougon, Departement of Surgery, University of Felix Houphouët Boigny, Ivory CoastPediatric Surgery, University Hospital Yopougon, Abidjan, Ivory Coast; Pediatric Surgery Hospital Yopougon, Departement of Surgery, University of Felix Houphouët Boigny, Ivory CoastPediatric Surgery, University Hospital Yopougon, Abidjan, Ivory Coast; Pediatric Surgery Hospital Yopougon, Departement of Surgery, University of Felix Houphouët Boigny, Ivory CoastPediatric Surgery, University Hospital Yopougon, Abidjan, Ivory Coast; Pediatric Surgery Hospital Yopougon, Departement of Surgery, University of Felix Houphouët Boigny, Ivory CoastBackground: Nicolau syndrome is a rare, potentially severe complication that may occur after any drug injection, particularly after intramuscular, subcutaneous or intraarticular injection. The pathogenesis of the necrosis is not completely known, it's presumed that ischemic necrosis is induced by direct vascular injury, perivascular inflammation, and vascular constriction. Few case was reported since the first description by Freudenthal in 1924 and Nicolau in 1925. Case report: we report two cases of Nicolau syndrome in the child after benzathine penicillin intramuscular injection in the thigh. The cases were complicated by a necrosis of the extremities and a Volkmann syndrome. Conclusion: Nicolau syndrome is an uncommon iatrogenic ischemic necrosis of the skin and deeper tissue. It is reported to occur after intramuscular injection for certain drugs such as benzathine penicillin. The pathogenesis is unknown but embolic occlusion, inflammatory and physical obstruction of blood vessels have been suggested in our cases. There is no standard guideline for its management.http://www.sciencedirect.com/science/article/pii/S2213576620302311ChildrenIntramuscular injectionNicolau syndrome |
| spellingShingle | Yapo Guy serge Kouamé Jean Baptiste Yaokreh Moufidath Sounkeré Samba Tembely Idalia Taguela Ajoumissi Koffi Eric N'goran Audrey Helene Thomas Koudou Thiery Hervé Odehouri Dibi Bertin Kouamé Ossenou Ouattara Nicolau syndrome after intramuscular benzathine penicillin injection Journal of Pediatric Surgery Case Reports Children Intramuscular injection Nicolau syndrome |
| title | Nicolau syndrome after intramuscular benzathine penicillin injection |
| title_full | Nicolau syndrome after intramuscular benzathine penicillin injection |
| title_fullStr | Nicolau syndrome after intramuscular benzathine penicillin injection |
| title_full_unstemmed | Nicolau syndrome after intramuscular benzathine penicillin injection |
| title_short | Nicolau syndrome after intramuscular benzathine penicillin injection |
| title_sort | nicolau syndrome after intramuscular benzathine penicillin injection |
| topic | Children Intramuscular injection Nicolau syndrome |
| url | http://www.sciencedirect.com/science/article/pii/S2213576620302311 |
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