Intestinal Colonization of <i>Campylobacter jejuni</i> and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler Chickens
<i>Campylobacter jejuni</i> is an important foodborne pathogen. Despite the lack of clinical signs associated with its colonization in poultry, it has been reported to interact with the intestinal immune system. However, little is known about the interaction between <i>C. jejuni<...
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MDPI AG
2023-06-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/11/7/1677 |
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| author | Sophie Chagneau Marie-Lou Gaucher Philippe Fravalo William P. Thériault Alexandre Thibodeau |
| author_facet | Sophie Chagneau Marie-Lou Gaucher Philippe Fravalo William P. Thériault Alexandre Thibodeau |
| author_sort | Sophie Chagneau |
| collection | DOAJ |
| description | <i>Campylobacter jejuni</i> is an important foodborne pathogen. Despite the lack of clinical signs associated with its colonization in poultry, it has been reported to interact with the intestinal immune system. However, little is known about the interaction between <i>C. jejuni</i> and the chicken immune system, especially in the context of hepatic dissemination. Therefore, to follow up on our previous study showing intestinal colonization and hepatic spread of <i>C. jejuni</i>, cecal tonsils and liver samples were collected from these birds to determine the mRNA levels of chemokines and cytokines. Serum samples were also collected to determine serum amyloid A (SAA) concentrations and specific IgY titers. Lack of Th17 induction was observed in the cecal tonsils of only the liver-contaminated groups. This hepatic dissemination was accompanied by innate, Th1 and Th2 immune responses in livers, as well as an increase in SAA concentrations and specific IgY levels in sera. <i>Campylobacter</i> appears to be able to restrain the induction of the chicken gut immunity in particular conditions, possibly enhancing its hepatic dissemination and thus eliciting systemic immune responses. Although <i>Campylobacter</i> is often recognized as a commensal-like bacterium in chickens, it seems to modulate the gut immune system and induce systemic immunity. |
| first_indexed | 2024-03-11T00:48:29Z |
| format | Article |
| id | doaj.art-05b1903011d6464089d55ee2b5c2b73a |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-11T00:48:29Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-05b1903011d6464089d55ee2b5c2b73a2023-11-18T20:34:53ZengMDPI AGMicroorganisms2076-26072023-06-01117167710.3390/microorganisms11071677Intestinal Colonization of <i>Campylobacter jejuni</i> and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler ChickensSophie Chagneau0Marie-Lou Gaucher1Philippe Fravalo2William P. Thériault3Alexandre Thibodeau4Research Chair in Meat Safety, Department of Pathology and Microbiology, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, CanadaResearch Chair in Meat Safety, Department of Pathology and Microbiology, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, CanadaChaire Agroalimentaire du Conservatoire National des Arts et Métiers, 22440 Ploufragan, FranceResearch Chair in Meat Safety, Department of Pathology and Microbiology, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, CanadaResearch Chair in Meat Safety, Department of Pathology and Microbiology, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, QC J2S 2M2, Canada<i>Campylobacter jejuni</i> is an important foodborne pathogen. Despite the lack of clinical signs associated with its colonization in poultry, it has been reported to interact with the intestinal immune system. However, little is known about the interaction between <i>C. jejuni</i> and the chicken immune system, especially in the context of hepatic dissemination. Therefore, to follow up on our previous study showing intestinal colonization and hepatic spread of <i>C. jejuni</i>, cecal tonsils and liver samples were collected from these birds to determine the mRNA levels of chemokines and cytokines. Serum samples were also collected to determine serum amyloid A (SAA) concentrations and specific IgY titers. Lack of Th17 induction was observed in the cecal tonsils of only the liver-contaminated groups. This hepatic dissemination was accompanied by innate, Th1 and Th2 immune responses in livers, as well as an increase in SAA concentrations and specific IgY levels in sera. <i>Campylobacter</i> appears to be able to restrain the induction of the chicken gut immunity in particular conditions, possibly enhancing its hepatic dissemination and thus eliciting systemic immune responses. Although <i>Campylobacter</i> is often recognized as a commensal-like bacterium in chickens, it seems to modulate the gut immune system and induce systemic immunity.https://www.mdpi.com/2076-2607/11/7/1677<i>Campylobacter jejuni</i>broiler chickensintestinal colonizationliver disseminationcecal tonsilslocal immune response |
| spellingShingle | Sophie Chagneau Marie-Lou Gaucher Philippe Fravalo William P. Thériault Alexandre Thibodeau Intestinal Colonization of <i>Campylobacter jejuni</i> and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler Chickens Microorganisms <i>Campylobacter jejuni</i> broiler chickens intestinal colonization liver dissemination cecal tonsils local immune response |
| title | Intestinal Colonization of <i>Campylobacter jejuni</i> and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler Chickens |
| title_full | Intestinal Colonization of <i>Campylobacter jejuni</i> and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler Chickens |
| title_fullStr | Intestinal Colonization of <i>Campylobacter jejuni</i> and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler Chickens |
| title_full_unstemmed | Intestinal Colonization of <i>Campylobacter jejuni</i> and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler Chickens |
| title_short | Intestinal Colonization of <i>Campylobacter jejuni</i> and Its Hepatic Dissemination Are Associated with Local and Systemic Immune Responses in Broiler Chickens |
| title_sort | intestinal colonization of i campylobacter jejuni i and its hepatic dissemination are associated with local and systemic immune responses in broiler chickens |
| topic | <i>Campylobacter jejuni</i> broiler chickens intestinal colonization liver dissemination cecal tonsils local immune response |
| url | https://www.mdpi.com/2076-2607/11/7/1677 |
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