Diisocyanates influence models of atopic dermatitis through direct activation of TRPA1

Diisocyanates influence models of atopic dermatitis through direct activation of TRPA1

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We recently used EPA databases to identify that isocyanates, most notably toluene diisocyanate (TDI), were the pollutant class with the strongest spatiotemporal and epidemiologic association with atopic dermatitis (AD). Our findings demonstrated that isocyanates like TDI disrupted lipid homeostasis...

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Bibliographic Details
Main Authors: Manoj Yadav, Prem Prashant Chaudhary, Brandon N. D’Souza, Grace Ratley, Jacquelyn Spathies, Sundar Ganesan, Jordan Zeldin, Ian A. Myles
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9987805/?tool=EBI

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