Association between TNFα - 308 G/A and IFN-γ +874A/T polymorphisms with oral lichen planus
Background: Oral lichen planus (OLP) is a chronic inflammatory disease that affects 0.1% to 4% of the population. The disease causes lesions in the buccal mucosa, gingiva, and rarely in the palate. In this study, the relationship between OLP and TNFα-308 G / A and IFN-γ + 874A / T polymorphisms was...
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2023-10-01
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| Series: | Journal of Kerman University of Medical Sciences |
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| Online Access: | https://jkmu.kmu.ac.ir/article_92361_295d913d669c22a5d44c02d817f9fd5e.pdf |
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| author | Nasrollah Saleh-gohari molok torabi Reihaneh Saleh Gohari Elham Abbaszadeh Malihe Saleh-gohari |
| author_facet | Nasrollah Saleh-gohari molok torabi Reihaneh Saleh Gohari Elham Abbaszadeh Malihe Saleh-gohari |
| author_sort | Nasrollah Saleh-gohari |
| collection | DOAJ |
| description | Background: Oral lichen planus (OLP) is a chronic inflammatory disease that affects 0.1% to 4% of the population. The disease causes lesions in the buccal mucosa, gingiva, and rarely in the palate. In this study, the relationship between OLP and TNFα-308 G / A and IFN-γ + 874A / T polymorphisms was investigated.Methods : In this case-control study, a sample of buccal mucosa was taken from 50 healthy individuals and 50 OLP patients referred to Kerman Faculty of Dentistry were included by easy sampling method. Then, the presence of TNFα-308 G / A and IFN-γ + 874A / T polymorphisms in the case and control groups was determined using ARM-PCR technique followed by sequencing.Results : Frequency of allele A and GA of TNF-α (-308G / A) gene was significantly higher than G and GG in OLP patients compared to control group (P-value <0.0001). Also, AA genotype of TNF-α (-308G / A) gene was not present in OLP patients. About IFN-γ + 874A / T polymorphism, the association between T allele and the risk of oral lichen planus was confirmed but it was not statistically significant (p-value: 0.068).Conclusion : There is a strong association between the A allele of TNF-α (-308G / A) and the risk of developing oral lichen planus, although this association between the IFN-γ + 874A / T genotype and Oral lichen planus was also confirmed, but it was not strong enough to be used to predict the likelihood of developing the disease. |
| first_indexed | 2024-03-08T17:54:53Z |
| format | Article |
| id | doaj.art-05b330c873964b8cac624c5459854714 |
| institution | Directory Open Access Journal |
| issn | 1023-9510 2008-2843 |
| language | English |
| last_indexed | 2024-03-08T17:54:53Z |
| publishDate | 2023-10-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Kerman University of Medical Sciences |
| spelling | doaj.art-05b330c873964b8cac624c54598547142024-01-02T05:20:18ZengKerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95102008-28432023-10-0130529029510.34172/jkmu.2023.4992361Association between TNFα - 308 G/A and IFN-γ +874A/T polymorphisms with oral lichen planusNasrollah Saleh-gohari0molok torabi1Reihaneh Saleh Gohari2Elham Abbaszadeh3Malihe Saleh-gohari4Department of Prosthodontics, Faculty of Dentistry, Kerman University of Medical Sciences, Shafa Street, Kerman, IranDepartment of Oral & Maxillofacial Pathology, Faculty of Dentistry, Kerman University of Medical Sciences, Shafa Street, Kerman, IranKerman University of Medical Sciences, Kerman, IranDepartment of Oral & Maxillofacial Medicine. Faculty of Dentistry, Kerman University of medical Sciences, Shafa Street, Kerman, IranDepartment of Medical Genetics, Afzalipour Faculty of Medicine, Kerman University of Medical Sciences, Kerman, IranBackground: Oral lichen planus (OLP) is a chronic inflammatory disease that affects 0.1% to 4% of the population. The disease causes lesions in the buccal mucosa, gingiva, and rarely in the palate. In this study, the relationship between OLP and TNFα-308 G / A and IFN-γ + 874A / T polymorphisms was investigated.Methods : In this case-control study, a sample of buccal mucosa was taken from 50 healthy individuals and 50 OLP patients referred to Kerman Faculty of Dentistry were included by easy sampling method. Then, the presence of TNFα-308 G / A and IFN-γ + 874A / T polymorphisms in the case and control groups was determined using ARM-PCR technique followed by sequencing.Results : Frequency of allele A and GA of TNF-α (-308G / A) gene was significantly higher than G and GG in OLP patients compared to control group (P-value <0.0001). Also, AA genotype of TNF-α (-308G / A) gene was not present in OLP patients. About IFN-γ + 874A / T polymorphism, the association between T allele and the risk of oral lichen planus was confirmed but it was not statistically significant (p-value: 0.068).Conclusion : There is a strong association between the A allele of TNF-α (-308G / A) and the risk of developing oral lichen planus, although this association between the IFN-γ + 874A / T genotype and Oral lichen planus was also confirmed, but it was not strong enough to be used to predict the likelihood of developing the disease.https://jkmu.kmu.ac.ir/article_92361_295d913d669c22a5d44c02d817f9fd5e.pdforal lichen planustnf-α geneifn-γ genepolymorphism |
| spellingShingle | Nasrollah Saleh-gohari molok torabi Reihaneh Saleh Gohari Elham Abbaszadeh Malihe Saleh-gohari Association between TNFα - 308 G/A and IFN-γ +874A/T polymorphisms with oral lichen planus Journal of Kerman University of Medical Sciences oral lichen planus tnf-α gene ifn-γ gene polymorphism |
| title | Association between TNFα - 308 G/A and IFN-γ +874A/T polymorphisms with oral lichen planus |
| title_full | Association between TNFα - 308 G/A and IFN-γ +874A/T polymorphisms with oral lichen planus |
| title_fullStr | Association between TNFα - 308 G/A and IFN-γ +874A/T polymorphisms with oral lichen planus |
| title_full_unstemmed | Association between TNFα - 308 G/A and IFN-γ +874A/T polymorphisms with oral lichen planus |
| title_short | Association between TNFα - 308 G/A and IFN-γ +874A/T polymorphisms with oral lichen planus |
| title_sort | association between tnfα 308 g a and ifn γ 874a t polymorphisms with oral lichen planus |
| topic | oral lichen planus tnf-α gene ifn-γ gene polymorphism |
| url | https://jkmu.kmu.ac.ir/article_92361_295d913d669c22a5d44c02d817f9fd5e.pdf |
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