Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers
Two diphenyl formamidine ligands, four dirhodium(II,II) complexes, and three axially modified low-valent dirhodium(II,II) metallodendrimers were synthesized and evaluated as anticancer agents against the A2780, A2780<i>cis</i>, and OVCAR-3 human ovarian cancer cell lines. The dirhodium(I...
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MDPI AG
2023-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/6/2671 |
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| author | Stephen de Doncker Eva Fischer-Fodor Cătălin Ioan Vlad Patriciu Achimas-Cadariu Gregory S. Smith Siyabonga Ngubane |
| author_facet | Stephen de Doncker Eva Fischer-Fodor Cătălin Ioan Vlad Patriciu Achimas-Cadariu Gregory S. Smith Siyabonga Ngubane |
| author_sort | Stephen de Doncker |
| collection | DOAJ |
| description | Two diphenyl formamidine ligands, four dirhodium(II,II) complexes, and three axially modified low-valent dirhodium(II,II) metallodendrimers were synthesized and evaluated as anticancer agents against the A2780, A2780<i>cis</i>, and OVCAR-3 human ovarian cancer cell lines. The dirhodium(II,II) complexes show moderate cytotoxic activity in the tested tumor cell lines, with acetate and methyl-substituted formamidinate compounds displaying increased cytotoxicity that is relative to cisplatin in the A2780<i>cis</i> cisplatin resistant cell line. Additionally, methyl- and fluoro-substituted formamidinate complexes showed comparable and increased cytotoxic activity in the OVCAR-3 cell line when compared to cisplatin. The low-valent metallodendrimers show some activity, but a general decrease in cytotoxicity was observed when compared to the precursor complexes in all but one case, which is where the more active acetate-derived metallodendrimer showed a lower IC<sub>50</sub> value in the OVCAR-3 cell line in comparison with the dirhodium(II,II) tetraacetate. |
| first_indexed | 2024-03-11T06:06:58Z |
| format | Article |
| id | doaj.art-05b34ca560ae4272abc499436813316f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T06:06:58Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-05b34ca560ae4272abc499436813316f2023-11-17T12:53:34ZengMDPI AGMolecules1420-30492023-03-01286267110.3390/molecules28062671Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent MetallodendrimersStephen de Doncker0Eva Fischer-Fodor1Cătălin Ioan Vlad2Patriciu Achimas-Cadariu3Gregory S. Smith4Siyabonga Ngubane5Department of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South AfricaTumour Biology Department, The Oncology Institute “Prof. Dr. Ion Chiricuţă”, 400015 Cluj-Napoca, RomaniaDepartment of Surgery, The Oncology Institute “Prof. Dr. Ion Chiricuţă”, 400015 Cluj-Napoca, RomaniaDepartment of Surgery, The Oncology Institute “Prof. Dr. Ion Chiricuţă”, 400015 Cluj-Napoca, RomaniaDepartment of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South AfricaDepartment of Chemistry, University of Cape Town, Rondebosch, Cape Town 7701, South AfricaTwo diphenyl formamidine ligands, four dirhodium(II,II) complexes, and three axially modified low-valent dirhodium(II,II) metallodendrimers were synthesized and evaluated as anticancer agents against the A2780, A2780<i>cis</i>, and OVCAR-3 human ovarian cancer cell lines. The dirhodium(II,II) complexes show moderate cytotoxic activity in the tested tumor cell lines, with acetate and methyl-substituted formamidinate compounds displaying increased cytotoxicity that is relative to cisplatin in the A2780<i>cis</i> cisplatin resistant cell line. Additionally, methyl- and fluoro-substituted formamidinate complexes showed comparable and increased cytotoxic activity in the OVCAR-3 cell line when compared to cisplatin. The low-valent metallodendrimers show some activity, but a general decrease in cytotoxicity was observed when compared to the precursor complexes in all but one case, which is where the more active acetate-derived metallodendrimer showed a lower IC<sub>50</sub> value in the OVCAR-3 cell line in comparison with the dirhodium(II,II) tetraacetate.https://www.mdpi.com/1420-3049/28/6/2671metallodrugdirhodium(II,II)formamidinecytotoxicitymetallodendrimers |
| spellingShingle | Stephen de Doncker Eva Fischer-Fodor Cătălin Ioan Vlad Patriciu Achimas-Cadariu Gregory S. Smith Siyabonga Ngubane Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers Molecules metallodrug dirhodium(II,II) formamidine cytotoxicity metallodendrimers |
| title | Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers |
| title_full | Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers |
| title_fullStr | Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers |
| title_full_unstemmed | Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers |
| title_short | Cytotoxicity Evaluation of Unmodified Paddlewheel Dirhodium(II,II)-Acetate/-Formamidinate Complexes and Their Axially Modified Low-Valent Metallodendrimers |
| title_sort | cytotoxicity evaluation of unmodified paddlewheel dirhodium ii ii acetate formamidinate complexes and their axially modified low valent metallodendrimers |
| topic | metallodrug dirhodium(II,II) formamidine cytotoxicity metallodendrimers |
| url | https://www.mdpi.com/1420-3049/28/6/2671 |
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