Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment

Energy Stress-Mediated Cytotoxicity in Tuberous Sclerosis Complex 2-Deficient Cells with Nelfinavir and Mefloquine Treatment

To find new anti-cancer drug therapies, we wanted to exploit homeostatic vulnerabilities within Tuberous Sclerosis Complex 2 (TSC2)-deficient cells with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivity. We show that nelfinavir and mefloquine synergize to selectively evoke a cytotoxic...

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Bibliographic Details
Main Authors: Henry D. McCann, Charlotte E. Johnson, Rachel J. Errington, D. Mark Davies, Elaine A. Dunlop, Andrew R. Tee
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Cancers
Subjects:
mTOR
nelfinavir
mefloquine
TSC
cancer therapy
energy homeostasis
ER stress
Online Access:http://www.mdpi.com/2072-6694/10/10/375

Internet

http://www.mdpi.com/2072-6694/10/10/375

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