Prognostic value and immunological role of BAIAP2L2 in liver hepatocellular carcinoma: A pan-cancer analysis
BackgroundIn recent years, the role of BAI1-associated protein 2-like 2 (BAIAP2L2) in the prognosis and immune microenvironment of various cancers has attracted increasing attention. However, its clinical value and immune infiltration in liver hepatocellular carcinoma (LIHC) remain unclear.Objective...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Surgery |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fsurg.2022.985034/full |
| _version_ | 1797990555104313344 |
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| author | Xiudan Han Xiudan Han Xiudan Han Wei Long Ying Liu Ying Liu Ying Liu Jixiong Xu Jixiong Xu Jixiong Xu |
| author_facet | Xiudan Han Xiudan Han Xiudan Han Wei Long Ying Liu Ying Liu Ying Liu Jixiong Xu Jixiong Xu Jixiong Xu |
| author_sort | Xiudan Han |
| collection | DOAJ |
| description | BackgroundIn recent years, the role of BAI1-associated protein 2-like 2 (BAIAP2L2) in the prognosis and immune microenvironment of various cancers has attracted increasing attention. However, its clinical value and immune infiltration in liver hepatocellular carcinoma (LIHC) remain unclear.ObjectiveTo investigate the prognostic value of BAIAP2L2 and its correlation with immune infiltration in LIHC, we conducted corresponding data mining.MethodsIn this study, The Cancer Genome Atlas, GTEx, StarBase, UALCAN, TIMER, GEPIA, Human Protein Atlas, Kaplan–Meier Plotter, cBioPortal, LinkedOmics, STRING and BioGPS databases were used to analyze BAIAP2L2 in cancers. Logistic regression and Cox regression were performed to analyze the correlation between clinical features and BAIAP2L2 expression in LIHC. In addition, the diagnostic and prognostic values of BAIAP2L2 in LIHC were determined by receiver operating characteristic (ROC) curves and nomograms. Single-sample gene set enrichment analysis (ssGSEA), BioGPS and TIMER were used to analyze the correlation between BAIAP2L2 and immune infiltration. More importantly, quantitative real-time polymerase chain reaction was used to verify BAIAP2L2 expression in a liver cancer cell line and a normal cell line. Visualization of data was mostly achieved using R language, version 3.6.3.ResultsHigh BAIAP2L2 levels indicated poor overall survival (OS) and disease-free survival (DFS) of patients with LIHC. Abnormally increased expression of BAIAP2L2 in LIHC may be the result of both genetic alterations and lower DNA methylation levels. Furthermore, Cox regression analysis showed that high BAIAP2L2 expression was an independent risk factor for OS and DFS in patients with liver cancer. ROC curves and nomograms also confirmed the diagnostic and prognostic values of BAIAP2L2 in LIHC. Additionally, a PPI network of BAIAP2L2 was established and results implyed that BAIAP2L2 interacts with MTSS1, AMPH, FCHO1, SYT9, PDK2, MTSS1L, PM20D1, CHST4 and PALM3. ssGSEA showed that BAIAP2L2 was associated with T cells and natural killer cells. Simultaneously, the TIMER database showed that the expression of BAIAP2L2 in LIHC was positively correlated with tumor infiltrating cells, including B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils and dendritic cells.ConclusionsThrough pan-cancer analysis, prognostic and immunological value of BAIAP2L2 in LIHC was identified. This is the first report on the potential of BAIAP2L2 as a prognostic biomarker and its correlation with immune infiltration in LIHC. |
| first_indexed | 2024-04-11T08:37:17Z |
| format | Article |
| id | doaj.art-05b53146f84d4c188e42554f8a87db0d |
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| language | English |
| last_indexed | 2024-04-11T08:37:17Z |
| publishDate | 2022-10-01 |
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| spelling | doaj.art-05b53146f84d4c188e42554f8a87db0d2022-12-22T04:34:17ZengFrontiers Media S.A.Frontiers in Surgery2296-875X2022-10-01910.3389/fsurg.2022.985034985034Prognostic value and immunological role of BAIAP2L2 in liver hepatocellular carcinoma: A pan-cancer analysisXiudan Han0Xiudan Han1Xiudan Han2Wei Long3Ying Liu4Ying Liu5Ying Liu6Jixiong Xu7Jixiong Xu8Jixiong Xu9Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, ChinaJiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, ChinaDepartment of Rheumatology, First Affiliated Hospital of Nanchang University, Nanchang, ChinaDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, ChinaJiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, ChinaDepartment of Endocrinology and Metabolism, First Affiliated Hospital of Nanchang University, Nanchang, ChinaJiangxi Clinical Research Center for Endocrine and Metabolic Disease, Nanchang, ChinaJiangxi Branch of National Clinical Research Center for Metabolic Disease, Nanchang, ChinaBackgroundIn recent years, the role of BAI1-associated protein 2-like 2 (BAIAP2L2) in the prognosis and immune microenvironment of various cancers has attracted increasing attention. However, its clinical value and immune infiltration in liver hepatocellular carcinoma (LIHC) remain unclear.ObjectiveTo investigate the prognostic value of BAIAP2L2 and its correlation with immune infiltration in LIHC, we conducted corresponding data mining.MethodsIn this study, The Cancer Genome Atlas, GTEx, StarBase, UALCAN, TIMER, GEPIA, Human Protein Atlas, Kaplan–Meier Plotter, cBioPortal, LinkedOmics, STRING and BioGPS databases were used to analyze BAIAP2L2 in cancers. Logistic regression and Cox regression were performed to analyze the correlation between clinical features and BAIAP2L2 expression in LIHC. In addition, the diagnostic and prognostic values of BAIAP2L2 in LIHC were determined by receiver operating characteristic (ROC) curves and nomograms. Single-sample gene set enrichment analysis (ssGSEA), BioGPS and TIMER were used to analyze the correlation between BAIAP2L2 and immune infiltration. More importantly, quantitative real-time polymerase chain reaction was used to verify BAIAP2L2 expression in a liver cancer cell line and a normal cell line. Visualization of data was mostly achieved using R language, version 3.6.3.ResultsHigh BAIAP2L2 levels indicated poor overall survival (OS) and disease-free survival (DFS) of patients with LIHC. Abnormally increased expression of BAIAP2L2 in LIHC may be the result of both genetic alterations and lower DNA methylation levels. Furthermore, Cox regression analysis showed that high BAIAP2L2 expression was an independent risk factor for OS and DFS in patients with liver cancer. ROC curves and nomograms also confirmed the diagnostic and prognostic values of BAIAP2L2 in LIHC. Additionally, a PPI network of BAIAP2L2 was established and results implyed that BAIAP2L2 interacts with MTSS1, AMPH, FCHO1, SYT9, PDK2, MTSS1L, PM20D1, CHST4 and PALM3. ssGSEA showed that BAIAP2L2 was associated with T cells and natural killer cells. Simultaneously, the TIMER database showed that the expression of BAIAP2L2 in LIHC was positively correlated with tumor infiltrating cells, including B cells, CD8+ T cells, CD4+ T cells, macrophages, neutrophils and dendritic cells.ConclusionsThrough pan-cancer analysis, prognostic and immunological value of BAIAP2L2 in LIHC was identified. This is the first report on the potential of BAIAP2L2 as a prognostic biomarker and its correlation with immune infiltration in LIHC.https://www.frontiersin.org/articles/10.3389/fsurg.2022.985034/fullBAIAP2L2liver hepatocellular carcinoma (LIHC)prognostic valueimmune infiltrationpan-cancer analysis |
| spellingShingle | Xiudan Han Xiudan Han Xiudan Han Wei Long Ying Liu Ying Liu Ying Liu Jixiong Xu Jixiong Xu Jixiong Xu Prognostic value and immunological role of BAIAP2L2 in liver hepatocellular carcinoma: A pan-cancer analysis Frontiers in Surgery BAIAP2L2 liver hepatocellular carcinoma (LIHC) prognostic value immune infiltration pan-cancer analysis |
| title | Prognostic value and immunological role of BAIAP2L2 in liver hepatocellular carcinoma: A pan-cancer analysis |
| title_full | Prognostic value and immunological role of BAIAP2L2 in liver hepatocellular carcinoma: A pan-cancer analysis |
| title_fullStr | Prognostic value and immunological role of BAIAP2L2 in liver hepatocellular carcinoma: A pan-cancer analysis |
| title_full_unstemmed | Prognostic value and immunological role of BAIAP2L2 in liver hepatocellular carcinoma: A pan-cancer analysis |
| title_short | Prognostic value and immunological role of BAIAP2L2 in liver hepatocellular carcinoma: A pan-cancer analysis |
| title_sort | prognostic value and immunological role of baiap2l2 in liver hepatocellular carcinoma a pan cancer analysis |
| topic | BAIAP2L2 liver hepatocellular carcinoma (LIHC) prognostic value immune infiltration pan-cancer analysis |
| url | https://www.frontiersin.org/articles/10.3389/fsurg.2022.985034/full |
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