Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.
Interleukin (IL)-1 signaling plays an important role in inflammatory processes, but also in malignant processes. The essential downstream event in IL-1 signaling is the activation of nuclear factor (NF)-κB, which leads to the expression of several genes that are involved in cell proliferation, invas...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24901233/pdf/?tool=EBI |
| _version_ | 1819180951143448576 |
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| author | Thomas Kalinski Saadettin Sel Heiko Hütten Martin Röpke Albert Roessner Norbert Nass |
| author_facet | Thomas Kalinski Saadettin Sel Heiko Hütten Martin Röpke Albert Roessner Norbert Nass |
| author_sort | Thomas Kalinski |
| collection | DOAJ |
| description | Interleukin (IL)-1 signaling plays an important role in inflammatory processes, but also in malignant processes. The essential downstream event in IL-1 signaling is the activation of nuclear factor (NF)-κB, which leads to the expression of several genes that are involved in cell proliferation, invasion, angiogenesis and metastasis, among them VEGF-A. As microenvironment-derived IL-1β is required for invasion and angiogenesis in malignant tumors, also in chondrosarcomas, we investigated IL-1β-induced signal transduction and VEGF-A expression in C3842 and SW1353 chondrosarcoma cells. We additionally performed in vitro angiogenesis assays and NF-κB-related gene expression analyses. Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK) to the IL-1 receptor. We demonstrate that IL-1 signaling and VEGF-A expression are blocked by Curcumin in chondrosarcoma cells. We further show that Curcumin blocks IL-1β-induced angiogenesis and NF-κB-related gene expression. We suppose that IL-1 blockade is an additional treatment option in chondrosarcoma, either by Curcumin, its derivatives or other IL-1 blocking agents. |
| first_indexed | 2024-12-22T22:22:29Z |
| format | Article |
| id | doaj.art-05b54962a90f4627aa2f736a18e0316f |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T22:22:29Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-05b54962a90f4627aa2f736a18e0316f2022-12-21T18:10:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9929610.1371/journal.pone.0099296Curcumin blocks interleukin-1 signaling in chondrosarcoma cells.Thomas KalinskiSaadettin SelHeiko HüttenMartin RöpkeAlbert RoessnerNorbert NassInterleukin (IL)-1 signaling plays an important role in inflammatory processes, but also in malignant processes. The essential downstream event in IL-1 signaling is the activation of nuclear factor (NF)-κB, which leads to the expression of several genes that are involved in cell proliferation, invasion, angiogenesis and metastasis, among them VEGF-A. As microenvironment-derived IL-1β is required for invasion and angiogenesis in malignant tumors, also in chondrosarcomas, we investigated IL-1β-induced signal transduction and VEGF-A expression in C3842 and SW1353 chondrosarcoma cells. We additionally performed in vitro angiogenesis assays and NF-κB-related gene expression analyses. Curcumin is a substance which inhibits IL-1 signaling very early by preventing the recruitment of IL-1 receptor associated kinase (IRAK) to the IL-1 receptor. We demonstrate that IL-1 signaling and VEGF-A expression are blocked by Curcumin in chondrosarcoma cells. We further show that Curcumin blocks IL-1β-induced angiogenesis and NF-κB-related gene expression. We suppose that IL-1 blockade is an additional treatment option in chondrosarcoma, either by Curcumin, its derivatives or other IL-1 blocking agents.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24901233/pdf/?tool=EBI |
| spellingShingle | Thomas Kalinski Saadettin Sel Heiko Hütten Martin Röpke Albert Roessner Norbert Nass Curcumin blocks interleukin-1 signaling in chondrosarcoma cells. PLoS ONE |
| title | Curcumin blocks interleukin-1 signaling in chondrosarcoma cells. |
| title_full | Curcumin blocks interleukin-1 signaling in chondrosarcoma cells. |
| title_fullStr | Curcumin blocks interleukin-1 signaling in chondrosarcoma cells. |
| title_full_unstemmed | Curcumin blocks interleukin-1 signaling in chondrosarcoma cells. |
| title_short | Curcumin blocks interleukin-1 signaling in chondrosarcoma cells. |
| title_sort | curcumin blocks interleukin 1 signaling in chondrosarcoma cells |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24901233/pdf/?tool=EBI |
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