Evaluation of a New Echocardiographic Tool for Cardiac Output Monitoring: An Experimental Study on A Controlled Hemorrhagic Shock Model in Anesthetized Piglets
Background: Cardiac output (CO) monitoring is recommended in patients with shock. The search for a reliable, rapid, and noninvasive tool is necessary for clinical practice. A new echocardiographic CO flow index (COF) is the automatic calculation of the sub-aortic VTI multiplied by the automatic calc...
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MDPI AG
2022-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/18/5420 |
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| author | Thibaut Markarian Laura Grau-Mercier Céline Occelli Florian Ajavon Pierre-Géraud Claret Fabien Coisy Xavier Bobbia |
| author_facet | Thibaut Markarian Laura Grau-Mercier Céline Occelli Florian Ajavon Pierre-Géraud Claret Fabien Coisy Xavier Bobbia |
| author_sort | Thibaut Markarian |
| collection | DOAJ |
| description | Background: Cardiac output (CO) monitoring is recommended in patients with shock. The search for a reliable, rapid, and noninvasive tool is necessary for clinical practice. A new echocardiographic CO flow index (COF) is the automatic calculation of the sub-aortic VTI multiplied by the automatic calculation of the heart rate (HR). The primary objective of this study was to show the correlation between COF and CO measured by thermodilution (COth) in a controlled hemorrhagic shock model in anesthetized piglets. Secondary objectives were to show the correlation between COth and CO calculated from left outflow tract (LVOT) measurement and manual VTI (COman), and CO measured by LVOT measurement and VTIauto (COauto). Methods: Prospective interventional experimental study. In seventeen ventilated and anesthetized piglets, a state of hemorrhagic shock was induced, maintained, then resuscitated and stabilized. The gold standard for CO and stroke volume measurement was thermodilution (COth). Results: 191 measurements were performed. The correlation coefficients (r) between COth and COF, COman, and COauto were 0.73 [0.62; 0.81], 0.66 [0.56; 0.74], and 0.73 [0.63; 0.81], respectively. Conclusions: In this study, the COF appears to have a strong correlation to the COth. This automatic index, which takes into account the HR and does not require the measurement of LVOT, could be a rapidly obtained index in clinical practice. |
| first_indexed | 2024-03-09T23:35:40Z |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T23:35:40Z |
| publishDate | 2022-09-01 |
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| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-05b582fa2de9435588e83e774e7eb8b92023-11-23T17:00:26ZengMDPI AGJournal of Clinical Medicine2077-03832022-09-011118542010.3390/jcm11185420Evaluation of a New Echocardiographic Tool for Cardiac Output Monitoring: An Experimental Study on A Controlled Hemorrhagic Shock Model in Anesthetized PigletsThibaut Markarian0Laura Grau-Mercier1Céline Occelli2Florian Ajavon3Pierre-Géraud Claret4Fabien Coisy5Xavier Bobbia6Emergency Department, Timone University Hospital, Aix-Marseille University, 13005 Marseille, FranceEmergency Department, Nîmes University Hospital, Montpellier University, UR UM 103 IMAGINE, 30029 Nîmes, FranceEmergency Department, Pasteur 2 University Hospital, Nice Côte-d’Azur University, 06000 Nice, FranceEmergency Department, Nîmes University Hospital, Montpellier University, UR UM 103 IMAGINE, 30029 Nîmes, FranceEmergency Department, Nîmes University Hospital, Montpellier University, UR UM 103 IMAGINE, 30029 Nîmes, FranceEmergency Department, Nîmes University Hospital, Montpellier University, UR UM 103 IMAGINE, 30029 Nîmes, FranceEmergency Department, Montpellier University Hospital, Montpellier University, UR UM 103 IMAGINE, 34295 Montpellier, FranceBackground: Cardiac output (CO) monitoring is recommended in patients with shock. The search for a reliable, rapid, and noninvasive tool is necessary for clinical practice. A new echocardiographic CO flow index (COF) is the automatic calculation of the sub-aortic VTI multiplied by the automatic calculation of the heart rate (HR). The primary objective of this study was to show the correlation between COF and CO measured by thermodilution (COth) in a controlled hemorrhagic shock model in anesthetized piglets. Secondary objectives were to show the correlation between COth and CO calculated from left outflow tract (LVOT) measurement and manual VTI (COman), and CO measured by LVOT measurement and VTIauto (COauto). Methods: Prospective interventional experimental study. In seventeen ventilated and anesthetized piglets, a state of hemorrhagic shock was induced, maintained, then resuscitated and stabilized. The gold standard for CO and stroke volume measurement was thermodilution (COth). Results: 191 measurements were performed. The correlation coefficients (r) between COth and COF, COman, and COauto were 0.73 [0.62; 0.81], 0.66 [0.56; 0.74], and 0.73 [0.63; 0.81], respectively. Conclusions: In this study, the COF appears to have a strong correlation to the COth. This automatic index, which takes into account the HR and does not require the measurement of LVOT, could be a rapidly obtained index in clinical practice.https://www.mdpi.com/2077-0383/11/18/5420shockhemorrhagicultrasoundechocardiographyexperimentalcardiac output |
| spellingShingle | Thibaut Markarian Laura Grau-Mercier Céline Occelli Florian Ajavon Pierre-Géraud Claret Fabien Coisy Xavier Bobbia Evaluation of a New Echocardiographic Tool for Cardiac Output Monitoring: An Experimental Study on A Controlled Hemorrhagic Shock Model in Anesthetized Piglets Journal of Clinical Medicine shock hemorrhagic ultrasound echocardiography experimental cardiac output |
| title | Evaluation of a New Echocardiographic Tool for Cardiac Output Monitoring: An Experimental Study on A Controlled Hemorrhagic Shock Model in Anesthetized Piglets |
| title_full | Evaluation of a New Echocardiographic Tool for Cardiac Output Monitoring: An Experimental Study on A Controlled Hemorrhagic Shock Model in Anesthetized Piglets |
| title_fullStr | Evaluation of a New Echocardiographic Tool for Cardiac Output Monitoring: An Experimental Study on A Controlled Hemorrhagic Shock Model in Anesthetized Piglets |
| title_full_unstemmed | Evaluation of a New Echocardiographic Tool for Cardiac Output Monitoring: An Experimental Study on A Controlled Hemorrhagic Shock Model in Anesthetized Piglets |
| title_short | Evaluation of a New Echocardiographic Tool for Cardiac Output Monitoring: An Experimental Study on A Controlled Hemorrhagic Shock Model in Anesthetized Piglets |
| title_sort | evaluation of a new echocardiographic tool for cardiac output monitoring an experimental study on a controlled hemorrhagic shock model in anesthetized piglets |
| topic | shock hemorrhagic ultrasound echocardiography experimental cardiac output |
| url | https://www.mdpi.com/2077-0383/11/18/5420 |
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