Truncating tau reveals different pathophysiological actions of oligomers in single neurons
Hill et al. examine the effects of full-length or truncated human recombinant tau on the excitability of hippocampal pyramidal neurons in mice. Their results suggest that effects seen with full-length tau oligomers can be dissected apart using tau truncations and highlights a tau-mediated alteration...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-021-02791-x |
| _version_ | 1818420759421255680 |
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| author | Emily Hill Thomas K. Karikari Juan Lantero-Rodriguez Henrik Zetterberg Kaj Blennow Magnus J. Richardson Mark J. Wall |
| author_facet | Emily Hill Thomas K. Karikari Juan Lantero-Rodriguez Henrik Zetterberg Kaj Blennow Magnus J. Richardson Mark J. Wall |
| author_sort | Emily Hill |
| collection | DOAJ |
| description | Hill et al. examine the effects of full-length or truncated human recombinant tau on the excitability of hippocampal pyramidal neurons in mice. Their results suggest that effects seen with full-length tau oligomers can be dissected apart using tau truncations and highlights a tau-mediated alteration in voltage-gated sodium channel currents. |
| first_indexed | 2024-12-14T12:59:34Z |
| format | Article |
| id | doaj.art-05b64a0a00e849388b47bc3893ecef99 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-12-14T12:59:34Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-05b64a0a00e849388b47bc3893ecef992022-12-21T23:00:29ZengNature PortfolioCommunications Biology2399-36422021-11-014111510.1038/s42003-021-02791-xTruncating tau reveals different pathophysiological actions of oligomers in single neuronsEmily Hill0Thomas K. Karikari1Juan Lantero-Rodriguez2Henrik Zetterberg3Kaj Blennow4Magnus J. Richardson5Mark J. Wall6School of Life Sciences, University of WarwickDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of GothenburgDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of GothenburgDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of GothenburgDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, University of GothenburgInstitute of Mathematics, University of WarwickSchool of Life Sciences, University of WarwickHill et al. examine the effects of full-length or truncated human recombinant tau on the excitability of hippocampal pyramidal neurons in mice. Their results suggest that effects seen with full-length tau oligomers can be dissected apart using tau truncations and highlights a tau-mediated alteration in voltage-gated sodium channel currents.https://doi.org/10.1038/s42003-021-02791-x |
| spellingShingle | Emily Hill Thomas K. Karikari Juan Lantero-Rodriguez Henrik Zetterberg Kaj Blennow Magnus J. Richardson Mark J. Wall Truncating tau reveals different pathophysiological actions of oligomers in single neurons Communications Biology |
| title | Truncating tau reveals different pathophysiological actions of oligomers in single neurons |
| title_full | Truncating tau reveals different pathophysiological actions of oligomers in single neurons |
| title_fullStr | Truncating tau reveals different pathophysiological actions of oligomers in single neurons |
| title_full_unstemmed | Truncating tau reveals different pathophysiological actions of oligomers in single neurons |
| title_short | Truncating tau reveals different pathophysiological actions of oligomers in single neurons |
| title_sort | truncating tau reveals different pathophysiological actions of oligomers in single neurons |
| url | https://doi.org/10.1038/s42003-021-02791-x |
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