Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer
Colorectal cancer (CRC) is the third and second cancer for incidence and mortality worldwide, respectively, and is becoming prevalent in developing countries. Most CRCs derive from polyps, especially adenomatous polyps, which can gradually transform into CRC. The family of Matrix Metalloproteinases...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/13/24/6226 |
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| author | Zahra Pezeshkian Stefania Nobili Noshad Peyravian Bahador Shojaee Haniye Nazari Hiva Soleimani Hamid Asadzadeh-Aghdaei Maziar Ashrafian Bonab Ehsan Nazemalhosseini-Mojarad Enrico Mini |
| author_facet | Zahra Pezeshkian Stefania Nobili Noshad Peyravian Bahador Shojaee Haniye Nazari Hiva Soleimani Hamid Asadzadeh-Aghdaei Maziar Ashrafian Bonab Ehsan Nazemalhosseini-Mojarad Enrico Mini |
| author_sort | Zahra Pezeshkian |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third and second cancer for incidence and mortality worldwide, respectively, and is becoming prevalent in developing countries. Most CRCs derive from polyps, especially adenomatous polyps, which can gradually transform into CRC. The family of Matrix Metalloproteinases (MMPs) plays a critical role in the initiation and progression of CRC. Prominent MMPs, including MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, and MMP-21, have been detected in CRC patients, and the expression of most of them correlates with a poor prognosis. Moreover, many studies have explored the inhibition of MMPs and targeted therapy for CRC, but there is not enough information about the role of MMPs in polyp malignancy. In this review, we discuss the role of MMPs in colorectal cancer and its pathogenesis |
| first_indexed | 2024-03-10T04:31:24Z |
| format | Article |
| id | doaj.art-05b8236a371f455a858a7ddcb1e10141 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T04:31:24Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-05b8236a371f455a858a7ddcb1e101412023-11-23T04:05:33ZengMDPI AGCancers2072-66942021-12-011324622610.3390/cancers13246226Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal CancerZahra Pezeshkian0Stefania Nobili1Noshad Peyravian2Bahador Shojaee3Haniye Nazari4Hiva Soleimani5Hamid Asadzadeh-Aghdaei6Maziar Ashrafian Bonab7Ehsan Nazemalhosseini-Mojarad8Enrico Mini9Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 19835-178, IranDepartment of Neurosciences, Imaging and Clinical Sciences, “G. D’Annunzio” University of Chieti-Pescara, 66100 Chieti, ItalyBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 19835-178, IranBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 19835-178, IranDepartment of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science, Islamic Azad University, Tehran 19395-1495, IranDepartment of General Biology, Faculty of Fundamental Science, Islamic Azad University of Shahr-E-Qods, Tehran 37515-374, IranBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 19835-178, IranSchool of Medicine, University of Sunderland, City Campus, Chester Road, Sunderland SR1 3SD, UKGastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran 19835-178, IranDepartment of Health Sciences, University of Florence, 50139 Florence, ItalyColorectal cancer (CRC) is the third and second cancer for incidence and mortality worldwide, respectively, and is becoming prevalent in developing countries. Most CRCs derive from polyps, especially adenomatous polyps, which can gradually transform into CRC. The family of Matrix Metalloproteinases (MMPs) plays a critical role in the initiation and progression of CRC. Prominent MMPs, including MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, and MMP-21, have been detected in CRC patients, and the expression of most of them correlates with a poor prognosis. Moreover, many studies have explored the inhibition of MMPs and targeted therapy for CRC, but there is not enough information about the role of MMPs in polyp malignancy. In this review, we discuss the role of MMPs in colorectal cancer and its pathogenesishttps://www.mdpi.com/2072-6694/13/24/6226Matrix Metalloproteinases (MMPs)polypcolorectal cancerTIMPsMMP polymorphismsMMP targeting |
| spellingShingle | Zahra Pezeshkian Stefania Nobili Noshad Peyravian Bahador Shojaee Haniye Nazari Hiva Soleimani Hamid Asadzadeh-Aghdaei Maziar Ashrafian Bonab Ehsan Nazemalhosseini-Mojarad Enrico Mini Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer Cancers Matrix Metalloproteinases (MMPs) polyp colorectal cancer TIMPs MMP polymorphisms MMP targeting |
| title | Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer |
| title_full | Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer |
| title_fullStr | Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer |
| title_full_unstemmed | Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer |
| title_short | Insights into the Role of Matrix Metalloproteinases in Precancerous Conditions and in Colorectal Cancer |
| title_sort | insights into the role of matrix metalloproteinases in precancerous conditions and in colorectal cancer |
| topic | Matrix Metalloproteinases (MMPs) polyp colorectal cancer TIMPs MMP polymorphisms MMP targeting |
| url | https://www.mdpi.com/2072-6694/13/24/6226 |
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