SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE
Abstract. In present work, we studied some interrelations between tobacco smoking and the processes of immune system stimulation in healthy blood donors. In our opinion, this issue is especially important for the big industrial center, with rather strong antigenic exposure of the organism. The level...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/447 |
| _version_ | 1826534301889462272 |
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| author | O. O. Obukhova A. N. Trunov O. M. Gorbenko A. P. Shvajuk A. V. Obukhov S. M. Chornaja |
| author_facet | O. O. Obukhova A. N. Trunov O. M. Gorbenko A. P. Shvajuk A. V. Obukhov S. M. Chornaja |
| author_sort | O. O. Obukhova |
| collection | DOAJ |
| description | Abstract. In present work, we studied some interrelations between tobacco smoking and the processes of immune system stimulation in healthy blood donors. In our opinion, this issue is especially important for the big industrial center, with rather strong antigenic exposure of the organism. The levels of circulating immune complexes (CIC) were used as a marker index which reflects specific antigen-antibody interactions during inflammation. According to the results obtained, the majority of persons who have high CIC levels were tobacco smokers (53.76%). Moreover, the percentage of persons with high CIC content, like as the mean values of this index is increased proportionally to the duration of smoking. A mixture of tobacco smoke components seems to exert direct toxic effect upon various compartments of the immune system and causes local irritation of bronchial tree, thus producing local and systemic inflammatory reaction. It is, possibly, an additional factor which determines activation of immune system, with a background of adverse antropogenic exposures typical to industrial centers. The data obtained allow us to affirm a toxic action of tobacco smoke upon the organism of smokers, with development of inflammatory reactions that are displayed as increased CIC levels at preclinical stage. |
| first_indexed | 2024-03-08T05:50:19Z |
| format | Article |
| id | doaj.art-05b967e8545945b197025f09de8811b9 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:20:51Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-05b967e8545945b197025f09de8811b92025-03-11T17:59:03ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0181919610.15789/1563-0625-2006-1-91-96444SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSUREO. O. Obukhova0A. N. Trunov1O. M. Gorbenko2A. P. Shvajuk3A. V. Obukhov4S. M. Chornaja5Научный центр клинической и экспериментальной медицины СО РАМН, г. НовосибирскНаучный центр клинической и экспериментальной медицины СО РАМН, г. НовосибирскНаучный центр клинической и экспериментальной медицины СО РАМН, г. НовосибирскНаучный центр клинической и экспериментальной медицины СО РАМН, г. НовосибирскМежрайонная централизованная лаборатория клинической иммунологии и диагностики СПИД, г. НовосибирскБольница скорой медицинской помощи № 2, г. НовосибирскAbstract. In present work, we studied some interrelations between tobacco smoking and the processes of immune system stimulation in healthy blood donors. In our opinion, this issue is especially important for the big industrial center, with rather strong antigenic exposure of the organism. The levels of circulating immune complexes (CIC) were used as a marker index which reflects specific antigen-antibody interactions during inflammation. According to the results obtained, the majority of persons who have high CIC levels were tobacco smokers (53.76%). Moreover, the percentage of persons with high CIC content, like as the mean values of this index is increased proportionally to the duration of smoking. A mixture of tobacco smoke components seems to exert direct toxic effect upon various compartments of the immune system and causes local irritation of bronchial tree, thus producing local and systemic inflammatory reaction. It is, possibly, an additional factor which determines activation of immune system, with a background of adverse antropogenic exposures typical to industrial centers. The data obtained allow us to affirm a toxic action of tobacco smoke upon the organism of smokers, with development of inflammatory reactions that are displayed as increased CIC levels at preclinical stage.https://www.mimmun.ru/mimmun/article/view/447immunitysmokinghealthy donorsimmune complexes |
| spellingShingle | O. O. Obukhova A. N. Trunov O. M. Gorbenko A. P. Shvajuk A. V. Obukhov S. M. Chornaja SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE Медицинская иммунология immunity smoking healthy donors immune complexes |
| title | SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE |
| title_full | SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE |
| title_fullStr | SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE |
| title_full_unstemmed | SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE |
| title_short | SOME ASPECTS OF IMMUNE SYSTEM FUNCTIONING IN HEALTHY DONORS SUBJECTED TO XENOGENOUS EXPOSURE |
| title_sort | some aspects of immune system functioning in healthy donors subjected to xenogenous exposure |
| topic | immunity smoking healthy donors immune complexes |
| url | https://www.mimmun.ru/mimmun/article/view/447 |
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