JWA suppresses proliferation in trastuzumab-resistant breast cancer by downregulating CDK12

Abstract Breast cancer is the most common cancer worldwide. JWA is a microtubule-associated protein that has been identified as a tumor suppressor, and its downregulation in tumors is an independent adverse prognostic factor. The objective of this study was to explore the expression, regulation, and...

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Bibliographic Details
Main Authors: Yan Liang, Chao Qian, Yinghong Xie, Xiang Huang, Junjie Chen, Yanlin Ren, Ziyi Fu, Yongfei Li, Tianyu Zeng, Fan Yang, Jianwei Zhou, Wei Li, Yongmei Yin, Changqing Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00693-9

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