The Efficacy and Safety of Intranasal Formulations of Ketamine and Esketamine for the Treatment of Major Depressive Disorder: A Systematic Review

The Efficacy and Safety of Intranasal Formulations of Ketamine and Esketamine for the Treatment of Major Depressive Disorder: A Systematic Review

Ketamine and its enantiomers represent an innovative glutamatergic agent as a treatment for individuals with treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal ideation and behavior. Intranasal (IN) formulations could allow for quick onset of action on depressive...

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Bibliographic Details
Main Authors: Ludivine Boudieu, Myriam Mennetrier, Pierre-Michel Llorca, Ludovic Samalin
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Pharmaceutics
Subjects:
ketamine
esketamine
intranasal formulation
major depressive disorder
treatment-resistant depression
Online Access:https://www.mdpi.com/1999-4923/15/12/2773

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