Kidney invasion occurred 2 years following liver transplantation for hepatic alveolar echinococcosis: a case report
Abstract Background The organ most commonly invaded in echinococcosis is the liver; the lungs, brain, kidneys, heart, and spleen are rarely invaded, and multi-organ involvement in echinococcosis is even rarer. No studies have reported renal invasion after liver transplantation for hepatic alveolar e...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-023-08788-7 |
| _version_ | 1827764624140795904 |
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| author | Qirui Hu Simin Chen Yichen Fan Qian Lu Manjun Deng Haining Fan |
| author_facet | Qirui Hu Simin Chen Yichen Fan Qian Lu Manjun Deng Haining Fan |
| author_sort | Qirui Hu |
| collection | DOAJ |
| description | Abstract Background The organ most commonly invaded in echinococcosis is the liver; the lungs, brain, kidneys, heart, and spleen are rarely invaded, and multi-organ involvement in echinococcosis is even rarer. No studies have reported renal invasion after liver transplantation for hepatic alveolar echinococcosis. Case presentation We report here a case of renal invasion 2 years after allogeneic liver transplantation in a 53-year-old female patient with hepatic alveolar echinococcosis combined with lung metastases. At the time of the first consultation, the lesion had been found to involve the second hepatic hilum combined with lung metastases, but the patient requested conservative treatment, and the lesion was not controlled by taking albendazole for 3 years. After discussion in the treatment group, it was decided to use allogeneic liver transplantation and lung segmental resection for surgical treatment, after which the patient was put on long-term oral immunosuppression. She was hospitalized 2 years later for low back pain and diagnosed with renal alveolar echinococcosis. Due to significant compression and left-sided renal insufficiency, the final option was to remove the diseased kidney. It is worth mentioning that signs of unexplained urinary tract infection were present throughout the course of treatment. Conclusion This study suggests that extra attention should be paid to the presence of cryptogenic lesions in patients with hepatic alveolar echinococcosis who already have definite metastatic lesions. Immunosuppressive drugs after liver transplantation in patients with hepatic echinococcosis may cause occult lesions to develop into active ones. In clinical practice, particular attention should be paid to patients with hepatic alveolar echinococcosis with long-term concomitant signs of unexplained urinary tract infections, which may be a precursor clinical feature of cryptogenic renal alveolar echinococcosis. |
| first_indexed | 2024-03-11T11:07:06Z |
| format | Article |
| id | doaj.art-05bb95e49b1a47d692987197d8e19ecd |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-03-11T11:07:06Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-05bb95e49b1a47d692987197d8e19ecd2023-11-12T12:07:53ZengBMCBMC Infectious Diseases1471-23342023-11-012311410.1186/s12879-023-08788-7Kidney invasion occurred 2 years following liver transplantation for hepatic alveolar echinococcosis: a case reportQirui Hu0Simin Chen1Yichen Fan2Qian Lu3Manjun Deng4Haining Fan5Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai UniversityDepartment of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai UniversityState Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medicine InstituteDepartment of Hepatopancreatobiliary Surgery, Tsinghua Changgung Hospital, Tsinghua UniversityDepartment of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai UniversityDepartment of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai UniversityAbstract Background The organ most commonly invaded in echinococcosis is the liver; the lungs, brain, kidneys, heart, and spleen are rarely invaded, and multi-organ involvement in echinococcosis is even rarer. No studies have reported renal invasion after liver transplantation for hepatic alveolar echinococcosis. Case presentation We report here a case of renal invasion 2 years after allogeneic liver transplantation in a 53-year-old female patient with hepatic alveolar echinococcosis combined with lung metastases. At the time of the first consultation, the lesion had been found to involve the second hepatic hilum combined with lung metastases, but the patient requested conservative treatment, and the lesion was not controlled by taking albendazole for 3 years. After discussion in the treatment group, it was decided to use allogeneic liver transplantation and lung segmental resection for surgical treatment, after which the patient was put on long-term oral immunosuppression. She was hospitalized 2 years later for low back pain and diagnosed with renal alveolar echinococcosis. Due to significant compression and left-sided renal insufficiency, the final option was to remove the diseased kidney. It is worth mentioning that signs of unexplained urinary tract infection were present throughout the course of treatment. Conclusion This study suggests that extra attention should be paid to the presence of cryptogenic lesions in patients with hepatic alveolar echinococcosis who already have definite metastatic lesions. Immunosuppressive drugs after liver transplantation in patients with hepatic echinococcosis may cause occult lesions to develop into active ones. In clinical practice, particular attention should be paid to patients with hepatic alveolar echinococcosis with long-term concomitant signs of unexplained urinary tract infections, which may be a precursor clinical feature of cryptogenic renal alveolar echinococcosis.https://doi.org/10.1186/s12879-023-08788-7Alveolar echinococcosisLiver transplantationAlbendazoleCase reportImmunosuppression therapy |
| spellingShingle | Qirui Hu Simin Chen Yichen Fan Qian Lu Manjun Deng Haining Fan Kidney invasion occurred 2 years following liver transplantation for hepatic alveolar echinococcosis: a case report BMC Infectious Diseases Alveolar echinococcosis Liver transplantation Albendazole Case report Immunosuppression therapy |
| title | Kidney invasion occurred 2 years following liver transplantation for hepatic alveolar echinococcosis: a case report |
| title_full | Kidney invasion occurred 2 years following liver transplantation for hepatic alveolar echinococcosis: a case report |
| title_fullStr | Kidney invasion occurred 2 years following liver transplantation for hepatic alveolar echinococcosis: a case report |
| title_full_unstemmed | Kidney invasion occurred 2 years following liver transplantation for hepatic alveolar echinococcosis: a case report |
| title_short | Kidney invasion occurred 2 years following liver transplantation for hepatic alveolar echinococcosis: a case report |
| title_sort | kidney invasion occurred 2 years following liver transplantation for hepatic alveolar echinococcosis a case report |
| topic | Alveolar echinococcosis Liver transplantation Albendazole Case report Immunosuppression therapy |
| url | https://doi.org/10.1186/s12879-023-08788-7 |
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