Management of Psychosis in Neuropsychiatric Lupus
Manifestations of neuropsychiatric systemic lupus erythematosus (NPSLE) are heterogeneous. Acute psychosis is an uncommon but well-recognized manifestation of NPSLE. With no specific biomarkers to date, the diagnosis of NPSLE relies on clinical acumen for circumstantial evidence and exclusion of imp...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2019-07-01
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| Series: | Journal of Clinical Rheumatology and Immunology |
| Subjects: | |
| Online Access: | http://www.worldscientific.com/doi/epdf/10.1142/S2661341719300015 |
| _version_ | 1818332704034258944 |
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| author | Di Kang Chi Chiu Mok |
| author_facet | Di Kang Chi Chiu Mok |
| author_sort | Di Kang |
| collection | DOAJ |
| description | Manifestations of neuropsychiatric systemic lupus erythematosus (NPSLE) are heterogeneous. Acute psychosis is an uncommon but well-recognized manifestation of NPSLE. With no specific biomarkers to date, the diagnosis of NPSLE relies on clinical acumen for circumstantial evidence and exclusion of important differential diagnoses. The attribution of psychosis to NPSLE is facilitated by the application attribution models. In particular, the American College of Rheumatology nomenclature, Systemic Lupus International Collaborating Clinics attribution models and Italian algorithm for the attribution of psychosis to NPSLE are revisited. The mainstay of treatment for psychosis attributable to NPSLE is immunosuppression and symptomatic control. In refractory cases, immunomodulatory and emerging biological agents may be considered. This article reviews the diagnostic dilemma, pathogenic mechanisms and treatment of psychosis in SLE patients. |
| first_indexed | 2024-12-13T13:39:58Z |
| format | Article |
| id | doaj.art-05bc1bd8d4554d3f9025650c9986ce74 |
| institution | Directory Open Access Journal |
| issn | 2661-3417 2661-3425 |
| language | English |
| last_indexed | 2024-12-13T13:39:58Z |
| publishDate | 2019-07-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Clinical Rheumatology and Immunology |
| spelling | doaj.art-05bc1bd8d4554d3f9025650c9986ce742022-12-21T23:43:36ZengWorld Scientific PublishingJournal of Clinical Rheumatology and Immunology2661-34172661-34252019-07-0119191710.1142/S266134171930001510.1142/S2661341719300015Management of Psychosis in Neuropsychiatric LupusDi Kang0Chi Chiu Mok1Department of Medicine, Tuen Mun Hospital, Hong Kong SAR, ChinaDepartment of Medicine, Tuen Mun Hospital, Hong Kong SAR, ChinaManifestations of neuropsychiatric systemic lupus erythematosus (NPSLE) are heterogeneous. Acute psychosis is an uncommon but well-recognized manifestation of NPSLE. With no specific biomarkers to date, the diagnosis of NPSLE relies on clinical acumen for circumstantial evidence and exclusion of important differential diagnoses. The attribution of psychosis to NPSLE is facilitated by the application attribution models. In particular, the American College of Rheumatology nomenclature, Systemic Lupus International Collaborating Clinics attribution models and Italian algorithm for the attribution of psychosis to NPSLE are revisited. The mainstay of treatment for psychosis attributable to NPSLE is immunosuppression and symptomatic control. In refractory cases, immunomodulatory and emerging biological agents may be considered. This article reviews the diagnostic dilemma, pathogenic mechanisms and treatment of psychosis in SLE patients.http://www.worldscientific.com/doi/epdf/10.1142/S2661341719300015systemic lupus erythematosusneuropsychiatric lupuslupus psychosiscorticosteroid-induced psychosiscyclophosphamiderituximab |
| spellingShingle | Di Kang Chi Chiu Mok Management of Psychosis in Neuropsychiatric Lupus Journal of Clinical Rheumatology and Immunology systemic lupus erythematosus neuropsychiatric lupus lupus psychosis corticosteroid-induced psychosis cyclophosphamide rituximab |
| title | Management of Psychosis in Neuropsychiatric Lupus |
| title_full | Management of Psychosis in Neuropsychiatric Lupus |
| title_fullStr | Management of Psychosis in Neuropsychiatric Lupus |
| title_full_unstemmed | Management of Psychosis in Neuropsychiatric Lupus |
| title_short | Management of Psychosis in Neuropsychiatric Lupus |
| title_sort | management of psychosis in neuropsychiatric lupus |
| topic | systemic lupus erythematosus neuropsychiatric lupus lupus psychosis corticosteroid-induced psychosis cyclophosphamide rituximab |
| url | http://www.worldscientific.com/doi/epdf/10.1142/S2661341719300015 |
| work_keys_str_mv | AT dikang managementofpsychosisinneuropsychiatriclupus AT chichiumok managementofpsychosisinneuropsychiatriclupus |