Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study
Background: Brain functional alterations have been observed in children with congenital sensorineural hearing loss (CSNHL). The purpose of this study was to assess the alterations of regional homogeneity in children with CSNHL.Methods: Forty-five children with CSNHL and 20 healthy controls were enro...
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Frontiers Media S.A.
2021-10-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.678910/full |
| _version_ | 1818736215920214016 |
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| author | Pingping Guo Siyuan Lang Muliang Jiang Yifeng Wang Zisan Zeng Zuguang Wen Yikang Liu Bihong T. Chen |
| author_facet | Pingping Guo Siyuan Lang Muliang Jiang Yifeng Wang Zisan Zeng Zuguang Wen Yikang Liu Bihong T. Chen |
| author_sort | Pingping Guo |
| collection | DOAJ |
| description | Background: Brain functional alterations have been observed in children with congenital sensorineural hearing loss (CSNHL). The purpose of this study was to assess the alterations of regional homogeneity in children with CSNHL.Methods: Forty-five children with CSNHL and 20 healthy controls were enrolled into this study. Brain resting-state functional MRI (rs-fMRI) for regional homogeneity including the Kendall coefficient consistency (KCC-ReHo) and the coherence-based parameter (Cohe-ReHo) was analyzed and compared between the two groups, i.e., the CSNHL group and the healthy control group.Results: Compared to the healthy controls, children with CSNHL showed increased Cohe-ReHo values in left calcarine and decreased values in bilateral ventrolateral prefrontal cortex (VLPFC) and right dorsolateral prefrontal cortex (DLPFC). Children with CSNHL also had increased KCC-ReHo values in the left calcarine, cuneus, precentral gyrus, and right superior parietal lobule (SPL) and decreased values in the left VLPFC and right DLPFC. Correlations were detected between the ReHo values and age of the children with CSNHL. There were positive correlations between ReHo values in the pre-cuneus/pre-frontal cortex and age (p < 0.05). There were negative correlations between ReHo values in bilateral temporal lobes, fusiform gyrus, parahippocampal gyrus and precentral gyrus, and age (p < 0.05).Conclusion: Children with CSNHL had RoHo alterations in the auditory, visual, motor, and other related brain cortices as compared to the healthy controls with normal hearing. There were significant correlations between ReHo values and age in brain regions involved in information integration and processing. Our study showed promising data using rs-fMRI ReHo parameters to assess brain functional alterations in children with CSNHL. |
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| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-18T00:33:37Z |
| publishDate | 2021-10-01 |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-05be07b5b963444fa9dde779f47d13112022-12-21T21:27:04ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-10-011510.3389/fnins.2021.678910678910Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI StudyPingping Guo0Siyuan Lang1Muliang Jiang2Yifeng Wang3Zisan Zeng4Zuguang Wen5Yikang Liu6Bihong T. Chen7Department of Medical Ultrasound, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiology, First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiology, First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaInstitute of Brain and Psychological Sciences, Sichuan Normal University, Chengdu, ChinaDepartment of Radiology, First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Radiology, Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Diagnostic Radiology, City of Hope National Medical Center, Duarte, CA, United StatesBackground: Brain functional alterations have been observed in children with congenital sensorineural hearing loss (CSNHL). The purpose of this study was to assess the alterations of regional homogeneity in children with CSNHL.Methods: Forty-five children with CSNHL and 20 healthy controls were enrolled into this study. Brain resting-state functional MRI (rs-fMRI) for regional homogeneity including the Kendall coefficient consistency (KCC-ReHo) and the coherence-based parameter (Cohe-ReHo) was analyzed and compared between the two groups, i.e., the CSNHL group and the healthy control group.Results: Compared to the healthy controls, children with CSNHL showed increased Cohe-ReHo values in left calcarine and decreased values in bilateral ventrolateral prefrontal cortex (VLPFC) and right dorsolateral prefrontal cortex (DLPFC). Children with CSNHL also had increased KCC-ReHo values in the left calcarine, cuneus, precentral gyrus, and right superior parietal lobule (SPL) and decreased values in the left VLPFC and right DLPFC. Correlations were detected between the ReHo values and age of the children with CSNHL. There were positive correlations between ReHo values in the pre-cuneus/pre-frontal cortex and age (p < 0.05). There were negative correlations between ReHo values in bilateral temporal lobes, fusiform gyrus, parahippocampal gyrus and precentral gyrus, and age (p < 0.05).Conclusion: Children with CSNHL had RoHo alterations in the auditory, visual, motor, and other related brain cortices as compared to the healthy controls with normal hearing. There were significant correlations between ReHo values and age in brain regions involved in information integration and processing. Our study showed promising data using rs-fMRI ReHo parameters to assess brain functional alterations in children with CSNHL.https://www.frontiersin.org/articles/10.3389/fnins.2021.678910/fullcongenital sensorineural hearing losskendall coefficient consistencycoherence-based regional homogeneityfunctional magnetic resonance imagingneuroimaging |
| spellingShingle | Pingping Guo Siyuan Lang Muliang Jiang Yifeng Wang Zisan Zeng Zuguang Wen Yikang Liu Bihong T. Chen Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study Frontiers in Neuroscience congenital sensorineural hearing loss kendall coefficient consistency coherence-based regional homogeneity functional magnetic resonance imaging neuroimaging |
| title | Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study |
| title_full | Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study |
| title_fullStr | Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study |
| title_full_unstemmed | Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study |
| title_short | Alterations of Regional Homogeneity in Children With Congenital Sensorineural Hearing Loss: A Resting-State fMRI Study |
| title_sort | alterations of regional homogeneity in children with congenital sensorineural hearing loss a resting state fmri study |
| topic | congenital sensorineural hearing loss kendall coefficient consistency coherence-based regional homogeneity functional magnetic resonance imaging neuroimaging |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.678910/full |
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