Environmental and occupational determinants of myelodysplastic syndrome: A case–control study from Pakistan
Abstract Background Myelodysplastic syndromes (MDS) are heterogeneous group of haematopoietic stem cell disorders and have variable reduction in the production of red cells, platelets and mature granulocytes. Aim We conducted a case–control study evaluating the environmental and occupational determi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-10-01
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| Series: | Cancer Reports |
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| Online Access: | https://doi.org/10.1002/cnr2.1580 |
| _version_ | 1811182395881160704 |
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| author | Nida Anwar Aisha Arshad Naveena Fatima Sumaira Shaheen Sumera Bukhari Tahir Shamsi |
| author_facet | Nida Anwar Aisha Arshad Naveena Fatima Sumaira Shaheen Sumera Bukhari Tahir Shamsi |
| author_sort | Nida Anwar |
| collection | DOAJ |
| description | Abstract Background Myelodysplastic syndromes (MDS) are heterogeneous group of haematopoietic stem cell disorders and have variable reduction in the production of red cells, platelets and mature granulocytes. Aim We conducted a case–control study evaluating the environmental and occupational determinants as risk factors of MDS. Methods A case–control study was conducted including 150 de novo MDS cases and 450 age and gender‐matched controls. Disease characteristics, sociodemographics and exposure to environmental and occupational determinants were collected through a questionnaire. Chi‐square test was applied to observe association, and binary logistic regression was applied to predict the odds of having MDS. Results A total of 600 participants were analysed. Those who were exposed to arsenic (OR 31.81, CI: 19.0–53.0, P‐value: .000), benzene (OR 1.564, CI: 1.07–2.27, P‐value: .01) using natural source of water (OR 3.563, CI: 2.29–5.53, P‐value: .000) and smokers (OR 3.1, P‐value: .000) were more likely to have MDS. Unmarried were less likely to acquire MDS than married (OR 0.239, CI: 0.15–0.36, P‐value: .000), Sindhi speaking were 1.419 times more likely to have MDS than participants speaking other languages. Uneducated participants were more likely to have MDS than educated and powder milk users were more likely to have MDS than dairy milk users. Conclusion Our results revealed that arsenic, use of natural source of water and benzene exposure might lead to higher risk of acquiring MDS. This study would be helpful to understand the aetiology of disease in Pakistani population. |
| first_indexed | 2024-04-11T09:30:48Z |
| format | Article |
| id | doaj.art-05bf8da2a6f64e4baee3506558d4dcb9 |
| institution | Directory Open Access Journal |
| issn | 2573-8348 |
| language | English |
| last_indexed | 2024-04-11T09:30:48Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Reports |
| spelling | doaj.art-05bf8da2a6f64e4baee3506558d4dcb92022-12-22T04:31:52ZengWileyCancer Reports2573-83482022-10-01510n/an/a10.1002/cnr2.1580Environmental and occupational determinants of myelodysplastic syndrome: A case–control study from PakistanNida Anwar0Aisha Arshad1Naveena Fatima2Sumaira Shaheen3Sumera Bukhari4Tahir Shamsi5National Institute of Blood Diseases and Bone Marrow Transplantation Karachi PakistanNational Institute of Blood Diseases and Bone Marrow Transplantation Karachi PakistanNational Institute of Blood Diseases and Bone Marrow Transplantation Karachi PakistanNational Institute of Blood Diseases and Bone Marrow Transplantation Karachi PakistanCambridge Health Alliance Harvard Medical School Cambridge Massachusetts USANational Institute of Blood Diseases and Bone Marrow Transplantation Karachi PakistanAbstract Background Myelodysplastic syndromes (MDS) are heterogeneous group of haematopoietic stem cell disorders and have variable reduction in the production of red cells, platelets and mature granulocytes. Aim We conducted a case–control study evaluating the environmental and occupational determinants as risk factors of MDS. Methods A case–control study was conducted including 150 de novo MDS cases and 450 age and gender‐matched controls. Disease characteristics, sociodemographics and exposure to environmental and occupational determinants were collected through a questionnaire. Chi‐square test was applied to observe association, and binary logistic regression was applied to predict the odds of having MDS. Results A total of 600 participants were analysed. Those who were exposed to arsenic (OR 31.81, CI: 19.0–53.0, P‐value: .000), benzene (OR 1.564, CI: 1.07–2.27, P‐value: .01) using natural source of water (OR 3.563, CI: 2.29–5.53, P‐value: .000) and smokers (OR 3.1, P‐value: .000) were more likely to have MDS. Unmarried were less likely to acquire MDS than married (OR 0.239, CI: 0.15–0.36, P‐value: .000), Sindhi speaking were 1.419 times more likely to have MDS than participants speaking other languages. Uneducated participants were more likely to have MDS than educated and powder milk users were more likely to have MDS than dairy milk users. Conclusion Our results revealed that arsenic, use of natural source of water and benzene exposure might lead to higher risk of acquiring MDS. This study would be helpful to understand the aetiology of disease in Pakistani population.https://doi.org/10.1002/cnr2.1580environmental exposuremyelodysplastic syndromesoccupational exposurePakistanrisk |
| spellingShingle | Nida Anwar Aisha Arshad Naveena Fatima Sumaira Shaheen Sumera Bukhari Tahir Shamsi Environmental and occupational determinants of myelodysplastic syndrome: A case–control study from Pakistan Cancer Reports environmental exposure myelodysplastic syndromes occupational exposure Pakistan risk |
| title | Environmental and occupational determinants of myelodysplastic syndrome: A case–control study from Pakistan |
| title_full | Environmental and occupational determinants of myelodysplastic syndrome: A case–control study from Pakistan |
| title_fullStr | Environmental and occupational determinants of myelodysplastic syndrome: A case–control study from Pakistan |
| title_full_unstemmed | Environmental and occupational determinants of myelodysplastic syndrome: A case–control study from Pakistan |
| title_short | Environmental and occupational determinants of myelodysplastic syndrome: A case–control study from Pakistan |
| title_sort | environmental and occupational determinants of myelodysplastic syndrome a case control study from pakistan |
| topic | environmental exposure myelodysplastic syndromes occupational exposure Pakistan risk |
| url | https://doi.org/10.1002/cnr2.1580 |
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