Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam
Objective: To determine the prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam and to explore its underlying causes. Methods: A retrospective cohort study was conducted where data on socio-demographics, clinical characteristics and treatment outcomes of all tuber...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Asian Pacific Journal of Tropical Medicine |
| Subjects: | |
| Online Access: | http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=1;spage=9;epage=15;aulast=Chaw |
| _version_ | 1828014138954088448 |
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| author | Liling Chaw Nurul Huda Jeludin Kyaw Thu |
| author_facet | Liling Chaw Nurul Huda Jeludin Kyaw Thu |
| author_sort | Liling Chaw |
| collection | DOAJ |
| description | Objective: To determine the prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam and to explore its underlying causes.
Methods: A retrospective cohort study was conducted where data on socio-demographics, clinical characteristics and treatment outcomes of all tuberculosis patients registered at the National tuberculosis Coordinating Centre between 2013 and 2017 were collected. Overall tuberculosis mortality and the proportion of tuberculosis-related deaths were calculated. Logistic regression analysis was used to determine the risk factors of tuberculosis mortality when compared to those who are cured and/or completed tuberculosis treatment.
Results: Of 1 107 tuberculosis cases, 99 died, giving an overall tuberculosis mortality rate of 8.9% (95% CI 7.4%-10.8%). Significant risk factors associated with tuberculosis mortality were age ⩾40 years (adjusted OR for 40-59 years was 3.89; 95% CI 1.13-1.69; adjusted OR for ⩾60 years was 22.3; 95% CI 7.27-91.9, using 20-39 years as reference), female sex (adjusted OR 1.74; 95% CI 1.09-2.79), having renal disease (adjusted OR 25.7; 95% CI 2.82-191.50) and having any cancers (adjusted OR 3.61; 95% CI 1.26-10.00). The majority (75.8%) of the recorded deaths were not related to tuberculosis.
Conclusions: Tuberculosis patients who were older than 40 years, female, and having renal disease and any cancer will need close monitoring in their management program to prevent tuberculosis mortality. Clinicians should also focus on other non-tuberculosis aspects of the patient’s medical history. |
| first_indexed | 2024-04-10T09:57:12Z |
| format | Article |
| id | doaj.art-05bfc15090084d0885c53d06561332ed |
| institution | Directory Open Access Journal |
| issn | 2352-4146 |
| language | English |
| last_indexed | 2024-04-10T09:57:12Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Asian Pacific Journal of Tropical Medicine |
| spelling | doaj.art-05bfc15090084d0885c53d06561332ed2023-02-16T12:13:08ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Tropical Medicine2352-41462023-01-0116191510.4103/1995-7645.368018Prevalence and risk factors associated with tuberculosis mortality in Brunei DarussalamLiling ChawNurul Huda JeludinKyaw ThuObjective: To determine the prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam and to explore its underlying causes. Methods: A retrospective cohort study was conducted where data on socio-demographics, clinical characteristics and treatment outcomes of all tuberculosis patients registered at the National tuberculosis Coordinating Centre between 2013 and 2017 were collected. Overall tuberculosis mortality and the proportion of tuberculosis-related deaths were calculated. Logistic regression analysis was used to determine the risk factors of tuberculosis mortality when compared to those who are cured and/or completed tuberculosis treatment. Results: Of 1 107 tuberculosis cases, 99 died, giving an overall tuberculosis mortality rate of 8.9% (95% CI 7.4%-10.8%). Significant risk factors associated with tuberculosis mortality were age ⩾40 years (adjusted OR for 40-59 years was 3.89; 95% CI 1.13-1.69; adjusted OR for ⩾60 years was 22.3; 95% CI 7.27-91.9, using 20-39 years as reference), female sex (adjusted OR 1.74; 95% CI 1.09-2.79), having renal disease (adjusted OR 25.7; 95% CI 2.82-191.50) and having any cancers (adjusted OR 3.61; 95% CI 1.26-10.00). The majority (75.8%) of the recorded deaths were not related to tuberculosis. Conclusions: Tuberculosis patients who were older than 40 years, female, and having renal disease and any cancer will need close monitoring in their management program to prevent tuberculosis mortality. Clinicians should also focus on other non-tuberculosis aspects of the patient’s medical history.http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=1;spage=9;epage=15;aulast=Chawmycobacterium infections; tuberculosis; mortality; brunei |
| spellingShingle | Liling Chaw Nurul Huda Jeludin Kyaw Thu Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam Asian Pacific Journal of Tropical Medicine mycobacterium infections; tuberculosis; mortality; brunei |
| title | Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam |
| title_full | Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam |
| title_fullStr | Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam |
| title_full_unstemmed | Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam |
| title_short | Prevalence and risk factors associated with tuberculosis mortality in Brunei Darussalam |
| title_sort | prevalence and risk factors associated with tuberculosis mortality in brunei darussalam |
| topic | mycobacterium infections; tuberculosis; mortality; brunei |
| url | http://www.apjtm.org/article.asp?issn=1995-7645;year=2023;volume=16;issue=1;spage=9;epage=15;aulast=Chaw |
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