The Correlation of Regulatory T (TReg) and Vitamin D3 in Pediatric Nephrotic Syndrome
Nephrotic syndrome (NS) is an autoimmune disease that correlates to the imbalance of regulatory T cells (TReg). This study was aimed to investigate the effect of vitamin D as adjuvant therapy of TReg population in pediatric nephrotic syndrome. This study was designed randomized clinical trial, doubl...
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| Format: | Article |
| Language: | English |
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University of Brawijaya
2018-01-01
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| Series: | Journal of Tropical Life Science |
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| Online Access: | http://jtrolis.ub.ac.id/index.php/jtrolis/article/view/769 |
| _version_ | 1797427837099048960 |
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| author | Yunika Nurtyas |
| author_facet | Yunika Nurtyas |
| author_sort | Yunika Nurtyas |
| collection | DOAJ |
| description | Nephrotic syndrome (NS) is an autoimmune disease that correlates to the imbalance of regulatory T cells (TReg). This study was aimed to investigate the effect of vitamin D as adjuvant therapy of TReg population in pediatric nephrotic syndrome. This study was designed randomized clinical trial, double blind, with pre- and post-test control groups involving 15 subjects newly diagnosed with NS. Subjects were divided into 2 groups, namely K1 for group treated with prednisone+vitamin D and K2 group for prednisone treatment only. The population of TReg in peripheral blood mononuclear cells (PBMC) was analyzed using flowcytometry. Vitamin D serum level was measured through ELISA method. Results showed that there was a significant elevation of TReg (independent t-test, p = 0.010) in K1 group, which was higher than in K2 group. The Pearson test in the K1 group showed that vitamin D level was positively correlated with TReg (p = 0.039, r = 0.779). |
| first_indexed | 2024-03-09T08:49:35Z |
| format | Article |
| id | doaj.art-05c04f65a437459f9e48f1c922288e35 |
| institution | Directory Open Access Journal |
| issn | 2087-5517 2527-4376 |
| language | English |
| last_indexed | 2024-03-09T08:49:35Z |
| publishDate | 2018-01-01 |
| publisher | University of Brawijaya |
| record_format | Article |
| series | Journal of Tropical Life Science |
| spelling | doaj.art-05c04f65a437459f9e48f1c922288e352023-12-02T14:30:37ZengUniversity of BrawijayaJournal of Tropical Life Science2087-55172527-43762018-01-0181434710.11594/jtls.08.01.08244The Correlation of Regulatory T (TReg) and Vitamin D3 in Pediatric Nephrotic SyndromeYunika Nurtyas0Medical Faculty, Brawijaya University, Malang 65145, IndonesiaNephrotic syndrome (NS) is an autoimmune disease that correlates to the imbalance of regulatory T cells (TReg). This study was aimed to investigate the effect of vitamin D as adjuvant therapy of TReg population in pediatric nephrotic syndrome. This study was designed randomized clinical trial, double blind, with pre- and post-test control groups involving 15 subjects newly diagnosed with NS. Subjects were divided into 2 groups, namely K1 for group treated with prednisone+vitamin D and K2 group for prednisone treatment only. The population of TReg in peripheral blood mononuclear cells (PBMC) was analyzed using flowcytometry. Vitamin D serum level was measured through ELISA method. Results showed that there was a significant elevation of TReg (independent t-test, p = 0.010) in K1 group, which was higher than in K2 group. The Pearson test in the K1 group showed that vitamin D level was positively correlated with TReg (p = 0.039, r = 0.779).http://jtrolis.ub.ac.id/index.php/jtrolis/article/view/769Nephrotic syndrome, vitamin D, TReg |
| spellingShingle | Yunika Nurtyas The Correlation of Regulatory T (TReg) and Vitamin D3 in Pediatric Nephrotic Syndrome Journal of Tropical Life Science Nephrotic syndrome, vitamin D, TReg |
| title | The Correlation of Regulatory T (TReg) and Vitamin D3 in Pediatric Nephrotic Syndrome |
| title_full | The Correlation of Regulatory T (TReg) and Vitamin D3 in Pediatric Nephrotic Syndrome |
| title_fullStr | The Correlation of Regulatory T (TReg) and Vitamin D3 in Pediatric Nephrotic Syndrome |
| title_full_unstemmed | The Correlation of Regulatory T (TReg) and Vitamin D3 in Pediatric Nephrotic Syndrome |
| title_short | The Correlation of Regulatory T (TReg) and Vitamin D3 in Pediatric Nephrotic Syndrome |
| title_sort | correlation of regulatory t treg and vitamin d3 in pediatric nephrotic syndrome |
| topic | Nephrotic syndrome, vitamin D, TReg |
| url | http://jtrolis.ub.ac.id/index.php/jtrolis/article/view/769 |
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