Coexistent meningioma in a patient with primary familial brain calcification: A case report
Primary familial brain calcification (PFBC) is an idiopathic pathology characterized by the development of calcific deposits in the supratentorial region such as telencephalon and diencephalon but also, in more extensive forms, in the cerebellum. Meningiomas are among the most common central nervous...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043323001140 |
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| author | Gianluca Scalia, MD Roberta Costanzo, MD Salvatore Marrone, MD Domenico Gerardo Iacopino, MD, PhD Gianluca Galvano, MD Giovanni Federico Nicoletti, MD Giuseppe Emmanuele Umana, MD, PhD, MSc, FACS |
| author_facet | Gianluca Scalia, MD Roberta Costanzo, MD Salvatore Marrone, MD Domenico Gerardo Iacopino, MD, PhD Gianluca Galvano, MD Giovanni Federico Nicoletti, MD Giuseppe Emmanuele Umana, MD, PhD, MSc, FACS |
| author_sort | Gianluca Scalia, MD |
| collection | DOAJ |
| description | Primary familial brain calcification (PFBC) is an idiopathic pathology characterized by the development of calcific deposits in the supratentorial region such as telencephalon and diencephalon but also, in more extensive forms, in the cerebellum. Meningiomas are among the most common central nervous system (CNS) tumors generally related to a good prognosis. The simultaneous presence of intracerebral or extra-axial tumors and PFBC represents an exceedingly rare occurrence. A 72-year-old female patient was admitted to our department because of anoculogyric crisis followed by generalized seizures. She performed a brain CT scan which showed widespread hyperdensities in the paraventricular supratentorial region, basal ganglia and at the level of bilateral cerebellar dentate nuclei, characteristics of PFBC. Concomitant left frontal and smaller right temporal extra-axial lesions were identified and then confirmed in a brain MRI. The patient underwent a microsurgical resection of the lesion and subsequent histological examination reported a meningothelial meningioma (WHO Grade I). According to our literature review, this is the first paper that reports the coexistence of both intracranial meningiomas and PFBC. To date, it is not possible to provide an exact correlation between pathogenesis and genetic mechanism underlying this association. |
| first_indexed | 2024-04-09T20:08:16Z |
| format | Article |
| id | doaj.art-05c1074347dc487e8b81fe57637f0bdd |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-04-09T20:08:16Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-05c1074347dc487e8b81fe57637f0bdd2023-04-01T08:46:19ZengElsevierRadiology Case Reports1930-04332023-05-0118518381843Coexistent meningioma in a patient with primary familial brain calcification: A case reportGianluca Scalia, MD0Roberta Costanzo, MD1Salvatore Marrone, MD2Domenico Gerardo Iacopino, MD, PhD3Gianluca Galvano, MD4Giovanni Federico Nicoletti, MD5Giuseppe Emmanuele Umana, MD, PhD, MSc, FACS6Department of Head and Neck Surgery, Neurosurgery Unit, Garibaldi Hospital, Piazza Santa Maria di Gesù, 5, Catania, 95123 Italy; Corresponding author.Experimental Biomedicine and Clinical Neurosciences, School of Medicine, Postgraduate Residency Program in Neurological Surgery, Neurosurgical Clinic, AOUP “Paolo Giaccone”, Via del Vespro 129, Palermo, 90127 ItalyExperimental Biomedicine and Clinical Neurosciences, School of Medicine, Postgraduate Residency Program in Neurological Surgery, Neurosurgical Clinic, AOUP “Paolo Giaccone”, Via del Vespro 129, Palermo, 90127 ItalyExperimental Biomedicine and Clinical Neurosciences, School of Medicine, Postgraduate Residency Program in Neurological Surgery, Neurosurgical Clinic, AOUP “Paolo Giaccone”, Via del Vespro 129, Palermo, 90127 ItalyDepartment of Diagnostic Imaging, Interventional Radiology and Neuroradiology, Garibaldi Hospital, Piazza Santa Maria di Gesù, 5, Catania, 95123, ItalyDepartment of Head and Neck Surgery, Neurosurgery Unit, Garibaldi Hospital, Piazza Santa Maria di Gesù, 5, Catania, 95123 ItalyDepartment of Neurosurgery, Cannizzaro Hospital, Trauma and Gamma Knife Center, Via Messina 829, Catania, 95126, ItalyPrimary familial brain calcification (PFBC) is an idiopathic pathology characterized by the development of calcific deposits in the supratentorial region such as telencephalon and diencephalon but also, in more extensive forms, in the cerebellum. Meningiomas are among the most common central nervous system (CNS) tumors generally related to a good prognosis. The simultaneous presence of intracerebral or extra-axial tumors and PFBC represents an exceedingly rare occurrence. A 72-year-old female patient was admitted to our department because of anoculogyric crisis followed by generalized seizures. She performed a brain CT scan which showed widespread hyperdensities in the paraventricular supratentorial region, basal ganglia and at the level of bilateral cerebellar dentate nuclei, characteristics of PFBC. Concomitant left frontal and smaller right temporal extra-axial lesions were identified and then confirmed in a brain MRI. The patient underwent a microsurgical resection of the lesion and subsequent histological examination reported a meningothelial meningioma (WHO Grade I). According to our literature review, this is the first paper that reports the coexistence of both intracranial meningiomas and PFBC. To date, it is not possible to provide an exact correlation between pathogenesis and genetic mechanism underlying this association.http://www.sciencedirect.com/science/article/pii/S1930043323001140Primary familial brain calcificationBrain tumorsMeningiomasCraniotomyGamma knife |
| spellingShingle | Gianluca Scalia, MD Roberta Costanzo, MD Salvatore Marrone, MD Domenico Gerardo Iacopino, MD, PhD Gianluca Galvano, MD Giovanni Federico Nicoletti, MD Giuseppe Emmanuele Umana, MD, PhD, MSc, FACS Coexistent meningioma in a patient with primary familial brain calcification: A case report Radiology Case Reports Primary familial brain calcification Brain tumors Meningiomas Craniotomy Gamma knife |
| title | Coexistent meningioma in a patient with primary familial brain calcification: A case report |
| title_full | Coexistent meningioma in a patient with primary familial brain calcification: A case report |
| title_fullStr | Coexistent meningioma in a patient with primary familial brain calcification: A case report |
| title_full_unstemmed | Coexistent meningioma in a patient with primary familial brain calcification: A case report |
| title_short | Coexistent meningioma in a patient with primary familial brain calcification: A case report |
| title_sort | coexistent meningioma in a patient with primary familial brain calcification a case report |
| topic | Primary familial brain calcification Brain tumors Meningiomas Craniotomy Gamma knife |
| url | http://www.sciencedirect.com/science/article/pii/S1930043323001140 |
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