ASSOCIATION OF ANEMIA WITH SERUM SEX HORMONE BINDING GLOBULIN LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME
Objective: To find association of anemia with serum sex hormone binding globulin levels in women with PCOS. Study Design: Cross sectional study. Place and Duration of Study: University of Health Sciences Lahore, from Jan 2018 to Jun 2018. Methodology: The study was conducted after approval...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2020-12-01
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| Series: | Pakistan Armed Forces Medical Journal |
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| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/5881/3078 |
| _version_ | 1818900200357363712 |
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| author | Hafiza Swaiba Afzal Syeda Rizwana Jafri Amna Muneeb Attya Zaheer Ehsan Ahmad Bushra Batool |
| author_facet | Hafiza Swaiba Afzal Syeda Rizwana Jafri Amna Muneeb Attya Zaheer Ehsan Ahmad Bushra Batool |
| author_sort | Hafiza Swaiba Afzal |
| collection | DOAJ |
| description | Objective: To find association of anemia with serum sex hormone binding globulin levels in women with PCOS.
Study Design: Cross sectional study.
Place and Duration of Study: University of Health Sciences Lahore, from Jan 2018 to Jun 2018.
Methodology: The study was conducted after approval from Ethics review committee of University of Health Sciences, Lahore. The Data was assessed by IBM-SPSS version 22. Normality of different continuous variables was checked by Shapiro-wilk test. Frequency distributions of study participants were calculated. Significance of the associations was assessed by Mann Whitney-U test and p-value <0.05 was taken as statistically significant.
Results: Most of the participants of our study were married (53.3%) and 77.9% of these married women don’t have children. 35 out of 60 were anemic (58.3%). The median ± interquartile ranges of age, BMI, SHBG and serum testosterone were 25 ± 9, 25.5 ± 9.75, 22.2 ± 13.08 and 0.24 ± 0.15 respectively. Mean Serum sex hormone binding globulin levels were found to be significantly associated with anemia (P=0.046) with mean ± SD of 16.30 ± 5.61 in anemic patients which was lower than the normal blood levels of SHBG (18-140 nmol/l). Anemia was nonsignificantly associated with the other factors like age, BMI and serum testosterone.
Conclusions: It was evident from this study that anemia is strongly associated with SHBG levels in PCOS. Further studies are required with larger sample size in future to rule out the underlying causes. |
| first_indexed | 2024-12-19T20:00:05Z |
| format | Article |
| id | doaj.art-05c132d2401f4ac181d1ec7254d0bbea |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-19T20:00:05Z |
| publishDate | 2020-12-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-05c132d2401f4ac181d1ec7254d0bbea2022-12-21T20:07:41ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422020-12-0170618701873ASSOCIATION OF ANEMIA WITH SERUM SEX HORMONE BINDING GLOBULIN LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROMEHafiza Swaiba Afzal0Syeda Rizwana Jafri1Amna Muneeb2Attya Zaheer3Ehsan Ahmad4Bushra Batool5Sahiwal Medical College Sahiwal, PakistanAzra Naheed Medical College, Lahore, PakistanAzra Naheed Medical College, Lahore, PakistanRashid Latif Medical College, Lahore, PakistanSughra Shafi Medical Complex, Sahara Medical College, Narowal, PakistanAllied Hospital Faisalabad, PakistanObjective: To find association of anemia with serum sex hormone binding globulin levels in women with PCOS. Study Design: Cross sectional study. Place and Duration of Study: University of Health Sciences Lahore, from Jan 2018 to Jun 2018. Methodology: The study was conducted after approval from Ethics review committee of University of Health Sciences, Lahore. The Data was assessed by IBM-SPSS version 22. Normality of different continuous variables was checked by Shapiro-wilk test. Frequency distributions of study participants were calculated. Significance of the associations was assessed by Mann Whitney-U test and p-value <0.05 was taken as statistically significant. Results: Most of the participants of our study were married (53.3%) and 77.9% of these married women don’t have children. 35 out of 60 were anemic (58.3%). The median ± interquartile ranges of age, BMI, SHBG and serum testosterone were 25 ± 9, 25.5 ± 9.75, 22.2 ± 13.08 and 0.24 ± 0.15 respectively. Mean Serum sex hormone binding globulin levels were found to be significantly associated with anemia (P=0.046) with mean ± SD of 16.30 ± 5.61 in anemic patients which was lower than the normal blood levels of SHBG (18-140 nmol/l). Anemia was nonsignificantly associated with the other factors like age, BMI and serum testosterone. Conclusions: It was evident from this study that anemia is strongly associated with SHBG levels in PCOS. Further studies are required with larger sample size in future to rule out the underlying causes.https://www.pafmj.org/index.php/PAFMJ/article/view/5881/3078anemiapolycystic ovary syndrome |
| spellingShingle | Hafiza Swaiba Afzal Syeda Rizwana Jafri Amna Muneeb Attya Zaheer Ehsan Ahmad Bushra Batool ASSOCIATION OF ANEMIA WITH SERUM SEX HORMONE BINDING GLOBULIN LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME Pakistan Armed Forces Medical Journal anemia polycystic ovary syndrome |
| title | ASSOCIATION OF ANEMIA WITH SERUM SEX HORMONE BINDING GLOBULIN LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME |
| title_full | ASSOCIATION OF ANEMIA WITH SERUM SEX HORMONE BINDING GLOBULIN LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME |
| title_fullStr | ASSOCIATION OF ANEMIA WITH SERUM SEX HORMONE BINDING GLOBULIN LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME |
| title_full_unstemmed | ASSOCIATION OF ANEMIA WITH SERUM SEX HORMONE BINDING GLOBULIN LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME |
| title_short | ASSOCIATION OF ANEMIA WITH SERUM SEX HORMONE BINDING GLOBULIN LEVELS IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME |
| title_sort | association of anemia with serum sex hormone binding globulin levels in patients with polycystic ovary syndrome |
| topic | anemia polycystic ovary syndrome |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/5881/3078 |
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